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An investigation of polymorphisms in the 4q1 3.3-21.1 CXC chemokine gene cluster for association with multiple sclerosis in Australians.
Mult Scler 2006; 12(6):710-22MS

Abstract

Susceptibility to multiple sclerosis (MS) is believed to result from the complex interaction of a number of genes, each with modest effect. Vital to the migration of cells to sites of inflammation, including the central nervous system, are chemokines, many of which are implicated in MS pathogenesis. Most of the CXC chemokine genes are encoded in a cluster on chromosome 4q13.3-21.1, which has been identified in several genome-wide screens as being potentially associated with MS. We conducted a two-stage analysis to investigate the chemokine gene cluster for association with MS. Initially, we sequenced the chemokine genes in several DNA pools to identify common polymorphisms, and then genotyped selected SNPs in 373 Australian MS trio families. We found no evidence that the CXC chemokine gene cluster is genetically associated with MS. However, the existence of common variants conferring small risk factors or rare variants with significant risk cannot be excluded.

Authors+Show Affiliations

The Institute for Immunology and Allergy Research, Westmead Millennium Institute, Westmead Campus, University of Sydney, Westmead, NSW 2145, Australia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17262998

Citation

Bugeja, M J., et al. "An Investigation of Polymorphisms in the 4q1 3.3-21.1 CXC Chemokine Gene Cluster for Association With Multiple Sclerosis in Australians." Multiple Sclerosis (Houndmills, Basingstoke, England), vol. 12, no. 6, 2006, pp. 710-22.
Bugeja MJ, Booth DR, Bennetts BH, et al. An investigation of polymorphisms in the 4q1 3.3-21.1 CXC chemokine gene cluster for association with multiple sclerosis in Australians. Mult Scler. 2006;12(6):710-22.
Bugeja, M. J., Booth, D. R., Bennetts, B. H., Heard, R. N., & Stewart, G. J. (2006). An investigation of polymorphisms in the 4q1 3.3-21.1 CXC chemokine gene cluster for association with multiple sclerosis in Australians. Multiple Sclerosis (Houndmills, Basingstoke, England), 12(6), pp. 710-22.
Bugeja MJ, et al. An Investigation of Polymorphisms in the 4q1 3.3-21.1 CXC Chemokine Gene Cluster for Association With Multiple Sclerosis in Australians. Mult Scler. 2006;12(6):710-22. PubMed PMID: 17262998.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - An investigation of polymorphisms in the 4q1 3.3-21.1 CXC chemokine gene cluster for association with multiple sclerosis in Australians. AU - Bugeja,M J, AU - Booth,D R, AU - Bennetts,B H, AU - Heard,R N S, AU - Stewart,G J, PY - 2007/2/1/pubmed PY - 2007/3/1/medline PY - 2007/2/1/entrez SP - 710 EP - 22 JF - Multiple sclerosis (Houndmills, Basingstoke, England) JO - Mult. Scler. VL - 12 IS - 6 N2 - Susceptibility to multiple sclerosis (MS) is believed to result from the complex interaction of a number of genes, each with modest effect. Vital to the migration of cells to sites of inflammation, including the central nervous system, are chemokines, many of which are implicated in MS pathogenesis. Most of the CXC chemokine genes are encoded in a cluster on chromosome 4q13.3-21.1, which has been identified in several genome-wide screens as being potentially associated with MS. We conducted a two-stage analysis to investigate the chemokine gene cluster for association with MS. Initially, we sequenced the chemokine genes in several DNA pools to identify common polymorphisms, and then genotyped selected SNPs in 373 Australian MS trio families. We found no evidence that the CXC chemokine gene cluster is genetically associated with MS. However, the existence of common variants conferring small risk factors or rare variants with significant risk cannot be excluded. SN - 1352-4585 UR - https://www.unboundmedicine.com/medline/citation/17262998/An_investigation_of_polymorphisms_in_the_4q1_3_3_21_1_CXC_chemokine_gene_cluster_for_association_with_multiple_sclerosis_in_Australians_ L2 - http://journals.sagepub.com/doi/full/10.1177/1352458506070964?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -