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[Expression of adhesion molecule CD62L on subpopulations of lymphocytes T and B in hypertrophied adenoids at sick's children with otitis media with effusion].
Otolaryngol Pol. 2006; 60(5):717-22.OP

Abstract

INTRODUCTION

Otitis media with effusion (OME) and hypertrophy adenoid (AH) are still common diseases during childhood. Adenoid has particular meaning in develop of immunological answer to inflammation in upper respiratory inclusive middle ear. The CD62L lymphocyte adhesion molecule plays an important role in controlling lymphocyte extravasations into adenoid and at sites of tissue infection. The aim of this study was evaluation of the percentage lymphocytes CD4+, CD8+, CD19+ with expression of superficial adhesive molecule CD62L and its expression in hypertrophied adenoids at sick's children with otitis media with effusion.

MATERIAL AND METHODS

In investigations has tested 37 children with otitis with effusion and 35 children from hypertrophied adenoids. Expression of adhesion molecule CD62L on lymphocytes of tissue adenoids estimated by flow cytometry method.

RESULTS

In this study showed higher significant percentage of lymphocytes CD19+CD62L+ in children in otitis media with effusion (OME. 59.33 +/- 9.65%) with reference to comparative group with hypertrophied adenoids (AH 53.47 +/- 9.67%). Mean fluorescence intensity CD62L was higher on subpopulation lymphocytes CD8+ and CD19+ at children with OME than AH.

CONCLUSIONS

The increase of percentage's lymphocytes CD62L+ in tissue of adenoids can to testify to enlarged migration lymphocytes from whole blood to adenoid. The increase of density of CD62L receptor on lymphocytes can be effect local inflammatory process.

Authors+Show Affiliations

Ratomski K
Zakład Laboratoryjnej Diagnostyki Pediatrycznej AM w Białymstoku. zldpam@poczta.fm
Wysocka J
No affiliation info available
Skotnicka B
No affiliation info available
Kasprzycka E
No affiliation info available
Hassmann-Poznańska E
No affiliation info available

MeSH

AdenoidsB-LymphocytesBiomarkersChildFemaleFlow CytometryHumansHypertrophyL-SelectinMaleOtitis Media with EffusionSeverity of Illness IndexStatistics, NonparametricT-Lymphocytes

Pub Type(s)

Comparative Study
English Abstract
Journal Article

Language

pol

PubMed ID

17263244

Citation

Ratomski, Karol, et al. "[Expression of Adhesion Molecule CD62L On Subpopulations of Lymphocytes T and B in Hypertrophied Adenoids at Sick's Children With Otitis Media With Effusion]." Otolaryngologia Polska = the Polish Otolaryngology, vol. 60, no. 5, 2006, pp. 717-22.
Ratomski K, Wysocka J, Skotnicka B, et al. [Expression of adhesion molecule CD62L on subpopulations of lymphocytes T and B in hypertrophied adenoids at sick's children with otitis media with effusion]. Otolaryngol Pol. 2006;60(5):717-22.
Ratomski, K., Wysocka, J., Skotnicka, B., Kasprzycka, E., & Hassmann-Poznańska, E. (2006). [Expression of adhesion molecule CD62L on subpopulations of lymphocytes T and B in hypertrophied adenoids at sick's children with otitis media with effusion]. Otolaryngologia Polska = the Polish Otolaryngology, 60(5), 717-22.
Ratomski K, et al. [Expression of Adhesion Molecule CD62L On Subpopulations of Lymphocytes T and B in Hypertrophied Adenoids at Sick's Children With Otitis Media With Effusion]. Otolaryngol Pol. 2006;60(5):717-22. PubMed PMID: 17263244.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Expression of adhesion molecule CD62L on subpopulations of lymphocytes T and B in hypertrophied adenoids at sick's children with otitis media with effusion]. AU - Ratomski,Karol, AU - Wysocka,Jolanta, AU - Skotnicka,Bozena, AU - Kasprzycka,Edwina, AU - Hassmann-Poznańska,Elzbieta, PY - 2007/2/1/pubmed PY - 2007/4/6/medline PY - 2007/2/1/entrez SP - 717 EP - 22 JF - Otolaryngologia polska = The Polish otolaryngology JO - Otolaryngol Pol VL - 60 IS - 5 N2 - INTRODUCTION: Otitis media with effusion (OME) and hypertrophy adenoid (AH) are still common diseases during childhood. Adenoid has particular meaning in develop of immunological answer to inflammation in upper respiratory inclusive middle ear. The CD62L lymphocyte adhesion molecule plays an important role in controlling lymphocyte extravasations into adenoid and at sites of tissue infection. The aim of this study was evaluation of the percentage lymphocytes CD4+, CD8+, CD19+ with expression of superficial adhesive molecule CD62L and its expression in hypertrophied adenoids at sick's children with otitis media with effusion. MATERIAL AND METHODS: In investigations has tested 37 children with otitis with effusion and 35 children from hypertrophied adenoids. Expression of adhesion molecule CD62L on lymphocytes of tissue adenoids estimated by flow cytometry method. RESULTS: In this study showed higher significant percentage of lymphocytes CD19+CD62L+ in children in otitis media with effusion (OME. 59.33 +/- 9.65%) with reference to comparative group with hypertrophied adenoids (AH 53.47 +/- 9.67%). Mean fluorescence intensity CD62L was higher on subpopulation lymphocytes CD8+ and CD19+ at children with OME than AH. CONCLUSIONS: The increase of percentage's lymphocytes CD62L+ in tissue of adenoids can to testify to enlarged migration lymphocytes from whole blood to adenoid. The increase of density of CD62L receptor on lymphocytes can be effect local inflammatory process. SN - 0030-6657 UR - https://www.unboundmedicine.com/medline/citation/17263244/[Expression_of_adhesion_molecule_CD62L_on_subpopulations_of_lymphocytes_T_and_B_in_hypertrophied_adenoids_at_sick's_children_with_otitis_media_with_effusion]_ L2 - https://medlineplus.gov/adenoids.html DB - PRIME DP - Unbound Medicine ER -