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[Expression Bcl-2 protein of lymphocytes T and B in hypertrophied adenoid in children with otitis media with effusion].
Otolaryngol Pol. 2006; 60(5):737-42.OP

Abstract

INTRODUCTION

The quantity of lymphocytes in adenoid and their cooperation in immunological processes is dependent on proliferation process and their migration to the effectory places. The most important process provide for equilibrium between lymphocytes of tonsils is apopotosis. Special meaning in induction this process has Bcl-2 family proteins with can be divided into pro-apoptotic and anti-apoptotic. An investigation was executed in hypertrophied adenoids with or without otitis media with effusion.

MATERIAL AND METHODS

By flow cytometry percentage of lymphocytes CD4+, CD8+, CD19+ and percentage of these lymphocytes with expression Bcl-2 proteins in hypertrophied adenoid and hypertrophied adenoid and otitis media with effusion was analyzed.

RESULTS

The percentage of lymphocytes CD4+Bcl-2+, CD8+Bcl-2+, CD19+Bcl-2+ was lower in hypertrophied adenoid and otitis media with effusion compared to the control group.

CONCLUSIONS

Tendency to lowered percentage of lymphocytes T and B with expression Bcl -2 protein in adenoids reflects likely the local immunity alterations.

Authors+Show Affiliations

Zelazowska-Rutkowska B
Zakład Laboratoryjnej Diagnostyki Pediatrycznej AM w Białymstoku. zelazowskab@wp.pl
Wysocka J
No affiliation info available
Hassmann-Poznańska E
No affiliation info available
Zak J
No affiliation info available

MeSH

AdenoidsAdolescentB-LymphocytesBiomarkersChildChild, PreschoolFemaleFlow CytometryHumansHypertrophyInfantMaleOtitis Media with EffusionProto-Oncogene Proteins c-bcl-2Severity of Illness IndexStatistics, NonparametricT-Lymphocytes

Pub Type(s)

English Abstract
Journal Article

Language

pol

PubMed ID

17263247

Citation

Zelazowska-Rutkowska, Beata, et al. "[Expression Bcl-2 Protein of Lymphocytes T and B in Hypertrophied Adenoid in Children With Otitis Media With Effusion]." Otolaryngologia Polska = the Polish Otolaryngology, vol. 60, no. 5, 2006, pp. 737-42.
Zelazowska-Rutkowska B, Wysocka J, Hassmann-Poznańska E, et al. [Expression Bcl-2 protein of lymphocytes T and B in hypertrophied adenoid in children with otitis media with effusion]. Otolaryngol Pol. 2006;60(5):737-42.
Zelazowska-Rutkowska, B., Wysocka, J., Hassmann-Poznańska, E., & Zak, J. (2006). [Expression Bcl-2 protein of lymphocytes T and B in hypertrophied adenoid in children with otitis media with effusion]. Otolaryngologia Polska = the Polish Otolaryngology, 60(5), 737-42.
Zelazowska-Rutkowska B, et al. [Expression Bcl-2 Protein of Lymphocytes T and B in Hypertrophied Adenoid in Children With Otitis Media With Effusion]. Otolaryngol Pol. 2006;60(5):737-42. PubMed PMID: 17263247.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Expression Bcl-2 protein of lymphocytes T and B in hypertrophied adenoid in children with otitis media with effusion]. AU - Zelazowska-Rutkowska,Beata, AU - Wysocka,Jolanta, AU - Hassmann-Poznańska,Elzbieta, AU - Zak,Janusz, PY - 2007/2/1/pubmed PY - 2007/4/6/medline PY - 2007/2/1/entrez SP - 737 EP - 42 JF - Otolaryngologia polska = The Polish otolaryngology JO - Otolaryngol Pol VL - 60 IS - 5 N2 - INTRODUCTION: The quantity of lymphocytes in adenoid and their cooperation in immunological processes is dependent on proliferation process and their migration to the effectory places. The most important process provide for equilibrium between lymphocytes of tonsils is apopotosis. Special meaning in induction this process has Bcl-2 family proteins with can be divided into pro-apoptotic and anti-apoptotic. An investigation was executed in hypertrophied adenoids with or without otitis media with effusion. MATERIAL AND METHODS: By flow cytometry percentage of lymphocytes CD4+, CD8+, CD19+ and percentage of these lymphocytes with expression Bcl-2 proteins in hypertrophied adenoid and hypertrophied adenoid and otitis media with effusion was analyzed. RESULTS: The percentage of lymphocytes CD4+Bcl-2+, CD8+Bcl-2+, CD19+Bcl-2+ was lower in hypertrophied adenoid and otitis media with effusion compared to the control group. CONCLUSIONS: Tendency to lowered percentage of lymphocytes T and B with expression Bcl -2 protein in adenoids reflects likely the local immunity alterations. SN - 0030-6657 UR - https://www.unboundmedicine.com/medline/citation/17263247/[Expression_Bcl_2_protein_of_lymphocytes_T_and_B_in_hypertrophied_adenoid_in_children_with_otitis_media_with_effusion]_ L2 - https://medlineplus.gov/adenoids.html DB - PRIME DP - Unbound Medicine ER -