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Levels of C3 in patients with severe, morbid and extreme obesity: its relationship to insulin resistance and different cardiovascular risk factors.

Abstract

OBJECTIVE

Increased C3 has been related to body mass index (BMI) and insulin resistance, although there are not sufficient studies in subjects with morbid obesity. The purpose of this study was to evaluate the levels of C3 as a function of the BMI in subjects of both sexes, with severe, morbid and extreme obesity, and their possible relationship to insulin resistance or associated diseases such as diabetes, hypertension and dyslipidemia.

SUBJECTS

The study included a total of 316 patients (110 men and 206 women) with severe obesity (17.1%), morbid obesity (54.4%) and extreme obesity (28.4%), with an average BMI of 46.70+/-7.37 kg/m2.

MEASUREMENTS

The glucose and insulin levels were determined baseline, and 2 h after a 75 g of oral glucose load. The homeostasis model of assessment for insulin resistance (HOMA-IR) was calculated. A lipid profile (total cholesterol, triglycerides, high-density lipoprotein cholesterol, apolipoprotein AI and apolipoprotein B100) was obtained and C3 levels determined by nephelometry.

RESULTS

When distributing the patients by quartiles of BMI, we found a progressive increase in the levels of C3, and no significant differences in the rest of analytical variables studied were found; the mean values of C3 were 127.78+/-29.7 mg/dl.A significant correlation was found between C3 and the BMI (r=0.263, P<0.001), baseline insulin (r=0.237, P=0.001) and HOMA-IR (r=0.237, P=0.001). High blood pressure was found in 111 patients, type 2 diabetes in 74 patients and dyslipidemia in 139 cases. When distributing the levels of C3 according to the number of associated risk factors (hypertension, diabetes and dyslipidemia), we found significant differences between these patients and those who presented no associated diseases (P<0.01).

CONCLUSION

A relationship between C3 and the progressive increase of BMI in subjects with severe, morbid or extreme obesity was established. This increase in C3 was closely related to insulin levels and the values for HOMA-IR. Furthermore, we also found an increase in C3 as more diseases related to insulin resistance, such as diabetes, hypertension and dyslipidemia, were associated with the obesity.

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  • Authors+Show Affiliations

    ,

    Endocrinology Service, Dr Peset University Hospital, Valencia, Spain. hernandez_antmij@gva.es

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    Source

    MeSH

    Adult
    Blood Glucose
    Blood Pressure
    Body Mass Index
    Cardiovascular Diseases
    Complement C3
    Diabetes Mellitus, Type 2
    Dyslipidemias
    Female
    Humans
    Hypertension
    Insulin
    Insulin Resistance
    Male
    Obesity
    Obesity, Morbid
    Risk Factors

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    17264851

    Citation

    Hernández-Mijares, A, et al. "Levels of C3 in Patients With Severe, Morbid and Extreme Obesity: Its Relationship to Insulin Resistance and Different Cardiovascular Risk Factors." International Journal of Obesity (2005), vol. 31, no. 6, 2007, pp. 927-32.
    Hernández-Mijares A, Jarabo-Bueno MM, López-Ruiz A, et al. Levels of C3 in patients with severe, morbid and extreme obesity: its relationship to insulin resistance and different cardiovascular risk factors. Int J Obes (Lond). 2007;31(6):927-32.
    Hernández-Mijares, A., Jarabo-Bueno, M. M., López-Ruiz, A., Solá-Izquierdo, E., Morillas-Ariño, C., & Martínez-Triguero, M. L. (2007). Levels of C3 in patients with severe, morbid and extreme obesity: its relationship to insulin resistance and different cardiovascular risk factors. International Journal of Obesity (2005), 31(6), pp. 927-32.
    Hernández-Mijares A, et al. Levels of C3 in Patients With Severe, Morbid and Extreme Obesity: Its Relationship to Insulin Resistance and Different Cardiovascular Risk Factors. Int J Obes (Lond). 2007;31(6):927-32. PubMed PMID: 17264851.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Levels of C3 in patients with severe, morbid and extreme obesity: its relationship to insulin resistance and different cardiovascular risk factors. AU - Hernández-Mijares,A, AU - Jarabo-Bueno,M M, AU - López-Ruiz,A, AU - Solá-Izquierdo,E, AU - Morillas-Ariño,C, AU - Martínez-Triguero,M L, Y1 - 2007/02/13/ PY - 2007/2/1/pubmed PY - 2007/8/19/medline PY - 2007/2/1/entrez SP - 927 EP - 32 JF - International journal of obesity (2005) JO - Int J Obes (Lond) VL - 31 IS - 6 N2 - OBJECTIVE: Increased C3 has been related to body mass index (BMI) and insulin resistance, although there are not sufficient studies in subjects with morbid obesity. The purpose of this study was to evaluate the levels of C3 as a function of the BMI in subjects of both sexes, with severe, morbid and extreme obesity, and their possible relationship to insulin resistance or associated diseases such as diabetes, hypertension and dyslipidemia. SUBJECTS: The study included a total of 316 patients (110 men and 206 women) with severe obesity (17.1%), morbid obesity (54.4%) and extreme obesity (28.4%), with an average BMI of 46.70+/-7.37 kg/m2. MEASUREMENTS: The glucose and insulin levels were determined baseline, and 2 h after a 75 g of oral glucose load. The homeostasis model of assessment for insulin resistance (HOMA-IR) was calculated. A lipid profile (total cholesterol, triglycerides, high-density lipoprotein cholesterol, apolipoprotein AI and apolipoprotein B100) was obtained and C3 levels determined by nephelometry. RESULTS: When distributing the patients by quartiles of BMI, we found a progressive increase in the levels of C3, and no significant differences in the rest of analytical variables studied were found; the mean values of C3 were 127.78+/-29.7 mg/dl.A significant correlation was found between C3 and the BMI (r=0.263, P<0.001), baseline insulin (r=0.237, P=0.001) and HOMA-IR (r=0.237, P=0.001). High blood pressure was found in 111 patients, type 2 diabetes in 74 patients and dyslipidemia in 139 cases. When distributing the levels of C3 according to the number of associated risk factors (hypertension, diabetes and dyslipidemia), we found significant differences between these patients and those who presented no associated diseases (P<0.01). CONCLUSION: A relationship between C3 and the progressive increase of BMI in subjects with severe, morbid or extreme obesity was established. This increase in C3 was closely related to insulin levels and the values for HOMA-IR. Furthermore, we also found an increase in C3 as more diseases related to insulin resistance, such as diabetes, hypertension and dyslipidemia, were associated with the obesity. SN - 0307-0565 UR - https://www.unboundmedicine.com/medline/citation/17264851/Levels_of_C3_in_patients_with_severe_morbid_and_extreme_obesity:_its_relationship_to_insulin_resistance_and_different_cardiovascular_risk_factors_ L2 - http://dx.doi.org/10.1038/sj.ijo.0803543 DB - PRIME DP - Unbound Medicine ER -