Tags

Type your tag names separated by a space and hit enter

Neuroprotective effects of ginsenosides.
Acta Neurobiol Exp (Wars). 2006; 66(4):369-75.AN

Abstract

Ginseng, the root of the Panax species, is a well-known herbal medicine. Traditionally it has been used in Korea, China and Japan for thousands of years. Nowadays it has become a popular and worldwide known health drug. Current scientific studies demonstrate in vivo and in vitro its beneficial effects in a wide range of pathological conditions such as cardiovascular disease, cancer, immune deficiency and hepatotoxicity. Ginsenosides or ginseng saponins as the active ingredients have antioxidant, anti-inflammatory, anti-apoptotic and immunostimulant properties, which raised speculations that these compounds could positively affect neurodegenerative disorders and delay neuronal aging. Conclusive clinical data in humans are still missing. However, results from animal studies and neuronal cell culture experiments indicate that ginsenosides can counteract and attenuate factors promoting neuronal death as environmental toxins, excitotoxic action of glutamate and rises in intracellular calcium, excessive release of free radicals and apoptotic events. Thus, neuroprotective actions of ginsenosides could come about as a valuable option to slow down neurodegenerative diseases.

Authors+Show Affiliations

Institute for Medical Chemistry, Veterinary Medical University, Veterindirplatz, 1 A-1210 Vienna, Austria. wolf.rausch@vu-wien.ac.atNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

17265697

Citation

Rausch, Wolf-Dieter, et al. "Neuroprotective Effects of Ginsenosides." Acta Neurobiologiae Experimentalis, vol. 66, no. 4, 2006, pp. 369-75.
Rausch WD, Liu S, Gille G, et al. Neuroprotective effects of ginsenosides. Acta Neurobiol Exp (Wars). 2006;66(4):369-75.
Rausch, W. D., Liu, S., Gille, G., & Radad, K. (2006). Neuroprotective effects of ginsenosides. Acta Neurobiologiae Experimentalis, 66(4), 369-75.
Rausch WD, et al. Neuroprotective Effects of Ginsenosides. Acta Neurobiol Exp (Wars). 2006;66(4):369-75. PubMed PMID: 17265697.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neuroprotective effects of ginsenosides. AU - Rausch,Wolf-Dieter, AU - Liu,Shu, AU - Gille,Gabriele, AU - Radad,Khaled, PY - 2007/2/3/pubmed PY - 2007/3/3/medline PY - 2007/2/3/entrez SP - 369 EP - 75 JF - Acta neurobiologiae experimentalis JO - Acta Neurobiol Exp (Wars) VL - 66 IS - 4 N2 - Ginseng, the root of the Panax species, is a well-known herbal medicine. Traditionally it has been used in Korea, China and Japan for thousands of years. Nowadays it has become a popular and worldwide known health drug. Current scientific studies demonstrate in vivo and in vitro its beneficial effects in a wide range of pathological conditions such as cardiovascular disease, cancer, immune deficiency and hepatotoxicity. Ginsenosides or ginseng saponins as the active ingredients have antioxidant, anti-inflammatory, anti-apoptotic and immunostimulant properties, which raised speculations that these compounds could positively affect neurodegenerative disorders and delay neuronal aging. Conclusive clinical data in humans are still missing. However, results from animal studies and neuronal cell culture experiments indicate that ginsenosides can counteract and attenuate factors promoting neuronal death as environmental toxins, excitotoxic action of glutamate and rises in intracellular calcium, excessive release of free radicals and apoptotic events. Thus, neuroprotective actions of ginsenosides could come about as a valuable option to slow down neurodegenerative diseases. SN - 0065-1400 UR - https://www.unboundmedicine.com/medline/citation/17265697/Neuroprotective_effects_of_ginsenosides_ L2 - https://ane.pl/linkout.php?vol=66&no=4&fpp=369 DB - PRIME DP - Unbound Medicine ER -