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Smoking and cognitive function in Parkinson's disease.
Mov Disord. 2007 Apr 15; 22(5):660-5.MD

Abstract

The risk of dementia among Parkinson's disease (PD) patients is greatly elevated compared to controls, yet little is known about determinants of cognitive function among PD patients. We assessed the relation between cigarette smoking prior to disease onset and later cognitive function among PD patients (n = 286) and age- and sex-matched controls (n = 1144) participating in the Nurses' Health Study and Health Professionals Follow-up Study. Both groups completed telephone-administered assessments of cognitive function. We used linear regression to calculate mean differences in cognitive test scores across smoking categories, adjusted for age, education, sex, age at onset of PD, and years since diagnosis. PD patients scored significantly worse on all tests than their matched controls. In analyses only among PD cases, but not among controls, current smokers at PD onset scored worse than never smokers on the Telephone Interview for Cognitive Status (difference = -0.82, 95% CI: -1.33, -0.30, P = 0.002) as well as on a global score combining results of all tests (difference = -0.36, 95% CI: -0.72, 0.01, P = 0.06). This difference was equivalent to the difference in global score observed among controls approximately 10 years apart in age. Analyses of pack-years of smoking prior to disease onset gave similar results. These findings, nested in prospective cohort studies, suggest that cigarette smoking prior to disease onset is associated with worse cognitive function in PD.

Authors+Show Affiliations

Department of Environmental Health, Harvard School of Public Health, Boston, MA 02215, USA. mweissko@hsph.harvard.eduNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17266085

Citation

Weisskopf, Marc G., et al. "Smoking and Cognitive Function in Parkinson's Disease." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 22, no. 5, 2007, pp. 660-5.
Weisskopf MG, Grodstein F, Ascherio A. Smoking and cognitive function in Parkinson's disease. Mov Disord. 2007;22(5):660-5.
Weisskopf, M. G., Grodstein, F., & Ascherio, A. (2007). Smoking and cognitive function in Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society, 22(5), 660-5.
Weisskopf MG, Grodstein F, Ascherio A. Smoking and Cognitive Function in Parkinson's Disease. Mov Disord. 2007 Apr 15;22(5):660-5. PubMed PMID: 17266085.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Smoking and cognitive function in Parkinson's disease. AU - Weisskopf,Marc G, AU - Grodstein,Francine, AU - Ascherio,Alberto, PY - 2007/2/3/pubmed PY - 2007/7/24/medline PY - 2007/2/3/entrez SP - 660 EP - 5 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov Disord VL - 22 IS - 5 N2 - The risk of dementia among Parkinson's disease (PD) patients is greatly elevated compared to controls, yet little is known about determinants of cognitive function among PD patients. We assessed the relation between cigarette smoking prior to disease onset and later cognitive function among PD patients (n = 286) and age- and sex-matched controls (n = 1144) participating in the Nurses' Health Study and Health Professionals Follow-up Study. Both groups completed telephone-administered assessments of cognitive function. We used linear regression to calculate mean differences in cognitive test scores across smoking categories, adjusted for age, education, sex, age at onset of PD, and years since diagnosis. PD patients scored significantly worse on all tests than their matched controls. In analyses only among PD cases, but not among controls, current smokers at PD onset scored worse than never smokers on the Telephone Interview for Cognitive Status (difference = -0.82, 95% CI: -1.33, -0.30, P = 0.002) as well as on a global score combining results of all tests (difference = -0.36, 95% CI: -0.72, 0.01, P = 0.06). This difference was equivalent to the difference in global score observed among controls approximately 10 years apart in age. Analyses of pack-years of smoking prior to disease onset gave similar results. These findings, nested in prospective cohort studies, suggest that cigarette smoking prior to disease onset is associated with worse cognitive function in PD. SN - 0885-3185 UR - https://www.unboundmedicine.com/medline/citation/17266085/Smoking_and_cognitive_function_in_Parkinson's_disease_ L2 - https://doi.org/10.1002/mds.21373 DB - PRIME DP - Unbound Medicine ER -