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Prevalence of the metabolic syndrome in patients with gout: the Third National Health and Nutrition Examination Survey.
Arthritis Rheum. 2007 Feb 15; 57(1):109-15.AR

Abstract

OBJECTIVE

To determine the prevalence of metabolic syndrome among patients with gout and to examine the association between the 2 conditions in a nationally representative sample of US adults.

METHODS

Using data from 8,807 participants age >or=20 years in the Third National Health and Nutrition Examination Survey (1988-1994), we determined the prevalence of metabolic syndrome among individuals with gout and quantified the magnitude of association between the 2 conditions. We used both the revised and original National Cholesterol Education Program Adult Treatment Panel III (NCEP/ATP III) criteria to define metabolic syndrome.

RESULTS

The prevalence (95% confidence interval [95% CI]) of metabolic syndrome according to revised NCEP/ATP III criteria was 62.8% (51.9-73.6) among individuals with gout and 25.4% (23.5-27.3) among individuals without gout. Using 2002 census data, approximately 3.5 million US adults with a history of gout have metabolic syndrome. The unadjusted and age- and sex-adjusted odds ratios (95% CI) of metabolic syndrome for individuals with gout were 4.96 (3.17-7.75) and 3.05 (2.01-4.61), respectively. With the original NCEP/ATP criteria, the corresponding prevalences were slightly lower, whereas the corresponding odds ratios were slightly higher. The stratified prevalences of metabolic syndrome by major associated factors of gout (i.e., body mass index, hypertension, and diabetes) remained substantially and significantly higher among those with gout than those without gout (all P values <0.05).

CONCLUSION

These findings indicate that the prevalence of metabolic syndrome is remarkably high among individuals with gout. Given the serious complications associated with metabolic syndrome, this frequent comorbidity should be recognized and taken into account in long-term treatment and overall health of individuals with gout.

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Authors+Show Affiliations

Choi HK
Arthritis Research Centre of Canada, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada. hchoi@partners.org
Ford ES
No affiliation info available
Li C
No affiliation info available
Curhan G
No affiliation info available

MeSH

AdultAgedComorbidityFemaleGoutHumansMaleMetabolic SyndromeMiddle AgedNutrition SurveysOdds RatioPrevalenceUnited States

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17266099

Citation

Choi, Hyon K., et al. "Prevalence of the Metabolic Syndrome in Patients With Gout: the Third National Health and Nutrition Examination Survey." Arthritis and Rheumatism, vol. 57, no. 1, 2007, pp. 109-15.
Choi HK, Ford ES, Li C, et al. Prevalence of the metabolic syndrome in patients with gout: the Third National Health and Nutrition Examination Survey. Arthritis Rheum. 2007;57(1):109-15.
Choi, H. K., Ford, E. S., Li, C., & Curhan, G. (2007). Prevalence of the metabolic syndrome in patients with gout: the Third National Health and Nutrition Examination Survey. Arthritis and Rheumatism, 57(1), 109-15.
Choi HK, et al. Prevalence of the Metabolic Syndrome in Patients With Gout: the Third National Health and Nutrition Examination Survey. Arthritis Rheum. 2007 Feb 15;57(1):109-15. PubMed PMID: 17266099.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence of the metabolic syndrome in patients with gout: the Third National Health and Nutrition Examination Survey. AU - Choi,Hyon K, AU - Ford,Earl S, AU - Li,Chaoyang, AU - Curhan,Gary, PY - 2007/2/3/pubmed PY - 2007/3/9/medline PY - 2007/2/3/entrez SP - 109 EP - 15 JF - Arthritis and rheumatism JO - Arthritis Rheum VL - 57 IS - 1 N2 - OBJECTIVE: To determine the prevalence of metabolic syndrome among patients with gout and to examine the association between the 2 conditions in a nationally representative sample of US adults. METHODS: Using data from 8,807 participants age >or=20 years in the Third National Health and Nutrition Examination Survey (1988-1994), we determined the prevalence of metabolic syndrome among individuals with gout and quantified the magnitude of association between the 2 conditions. We used both the revised and original National Cholesterol Education Program Adult Treatment Panel III (NCEP/ATP III) criteria to define metabolic syndrome. RESULTS: The prevalence (95% confidence interval [95% CI]) of metabolic syndrome according to revised NCEP/ATP III criteria was 62.8% (51.9-73.6) among individuals with gout and 25.4% (23.5-27.3) among individuals without gout. Using 2002 census data, approximately 3.5 million US adults with a history of gout have metabolic syndrome. The unadjusted and age- and sex-adjusted odds ratios (95% CI) of metabolic syndrome for individuals with gout were 4.96 (3.17-7.75) and 3.05 (2.01-4.61), respectively. With the original NCEP/ATP criteria, the corresponding prevalences were slightly lower, whereas the corresponding odds ratios were slightly higher. The stratified prevalences of metabolic syndrome by major associated factors of gout (i.e., body mass index, hypertension, and diabetes) remained substantially and significantly higher among those with gout than those without gout (all P values <0.05). CONCLUSION: These findings indicate that the prevalence of metabolic syndrome is remarkably high among individuals with gout. Given the serious complications associated with metabolic syndrome, this frequent comorbidity should be recognized and taken into account in long-term treatment and overall health of individuals with gout. SN - 0004-3591 UR - https://www.unboundmedicine.com/medline/citation/17266099/Prevalence_of_the_metabolic_syndrome_in_patients_with_gout:_the_Third_National_Health_and_Nutrition_Examination_Survey_ L2 - https://doi.org/10.1002/art.22466 DB - PRIME DP - Unbound Medicine ER -