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Microbicides and other topical agents in the prevention of HIV and sexually transmitted infections.
Expert Rev Anti Infect Ther. 2007 Feb; 5(1):77-88.ER

Abstract

According to information from UNAIDS, more than 42 million individuals are living with HIV worldwide. Most infected individuals live in developing countries where the availability of antiretroviral agents is still limited. As this pandemic is increasing largely through mucosal transmission, new methods of prevention are urgently needed. If available, agents that block HIV prior to or early after contact with mucosal epithelia would decrease the incidence of HIV infection and, therefore, potentially save millions of lives over the next few decades. Topically applied microbicides acting against HIV-1 can be subdivided into four subgroups, including agents directly inhibiting pathogens, agents acting on genital pH, agents blocking pathogen entry and replication inhibitors. In addition, microbicides might also allow fighting against other sexually transmitted infections, such as herpes simplex viruses. With concerted efforts directed towards developing efficient microbicides, topical anti-infective compounds may well become a new weapon against sexually transmitted infections, including HIV, in everyday clinical practice.

Authors+Show Affiliations

Department of Dermatology and Venereology, University Hospital and Medical School of Geneva, Geneva, Switzerland. damjan.nikolic@medecine.unige.chNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

17266456

Citation

Nikolic, Damjan S., et al. "Microbicides and Other Topical Agents in the Prevention of HIV and Sexually Transmitted Infections." Expert Review of Anti-infective Therapy, vol. 5, no. 1, 2007, pp. 77-88.
Nikolic DS, Garcia E, Piguet V. Microbicides and other topical agents in the prevention of HIV and sexually transmitted infections. Expert Rev Anti Infect Ther. 2007;5(1):77-88.
Nikolic, D. S., Garcia, E., & Piguet, V. (2007). Microbicides and other topical agents in the prevention of HIV and sexually transmitted infections. Expert Review of Anti-infective Therapy, 5(1), 77-88.
Nikolic DS, Garcia E, Piguet V. Microbicides and Other Topical Agents in the Prevention of HIV and Sexually Transmitted Infections. Expert Rev Anti Infect Ther. 2007;5(1):77-88. PubMed PMID: 17266456.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Microbicides and other topical agents in the prevention of HIV and sexually transmitted infections. AU - Nikolic,Damjan S, AU - Garcia,Eduardo, AU - Piguet,Vincent, PY - 2007/2/3/pubmed PY - 2007/3/31/medline PY - 2007/2/3/entrez SP - 77 EP - 88 JF - Expert review of anti-infective therapy JO - Expert Rev Anti Infect Ther VL - 5 IS - 1 N2 - According to information from UNAIDS, more than 42 million individuals are living with HIV worldwide. Most infected individuals live in developing countries where the availability of antiretroviral agents is still limited. As this pandemic is increasing largely through mucosal transmission, new methods of prevention are urgently needed. If available, agents that block HIV prior to or early after contact with mucosal epithelia would decrease the incidence of HIV infection and, therefore, potentially save millions of lives over the next few decades. Topically applied microbicides acting against HIV-1 can be subdivided into four subgroups, including agents directly inhibiting pathogens, agents acting on genital pH, agents blocking pathogen entry and replication inhibitors. In addition, microbicides might also allow fighting against other sexually transmitted infections, such as herpes simplex viruses. With concerted efforts directed towards developing efficient microbicides, topical anti-infective compounds may well become a new weapon against sexually transmitted infections, including HIV, in everyday clinical practice. SN - 1744-8336 UR - https://www.unboundmedicine.com/medline/citation/17266456/Microbicides_and_other_topical_agents_in_the_prevention_of_HIV_and_sexually_transmitted_infections_ L2 - https://www.tandfonline.com/doi/full/10.1586/14787210.5.1.77 DB - PRIME DP - Unbound Medicine ER -