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Sublethal impact of short term exposure to the organophosphate pesticide azamethiphos in the marine mollusc Mytilus edulis.
Mar Pollut Bull. 2007 Apr; 54(4):396-402.MP

Abstract

Concern has been raised that the increased use of pesticides in intensive aquaculture practices may cause adverse sublethal effects to non-target aquatic species. Azamethiphos is an organophosphate (OP) pesticide used to combat sea lice infestations in farmed salmonids. Here, the sublethal impact on the blue mussel, Mytilus edulis, of short term exposure to azamethiphos was determined. The testing regime included biomarkers of exposure (acetylcholinesterase activity), cytotoxicity (neutral red retention), immune function (phagocytic index) and physiological condition (feeding rate). The distribution and sensitivity of M. edulis acetylcholinesterase to inhibition by azamethiphos was first determined, yielding IC(50) values of 0.736 and 1.30 mg l(-1) for gill and haemolymph, respectively. Exposure of mussels to 0.1 mg l(-1) azamethiphos for periods of up to 24h caused a significant reduction in acetylcholinesterase activity in both the haemolymph (P<0.0002) and the gill (P<0.002), alteration in cell viability (P<0.02) and decrease in phagocytic index (P<0.03). The feeding rate remained unaffected. The results support the hypothesis that, in addition to its neurotoxic effects, azamethiphos can modulate haemocyte function and immune defence in M. edulis at environmentally relevant concentrations after only a few hours.

Authors+Show Affiliations

Ecotoxicology and Stress Biology Research Centre, School of Biological Sciences, University of Plymouth, Portland Square, Drake Circus, Plymouth PL4 8AA, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17266995

Citation

Canty, M N., et al. "Sublethal Impact of Short Term Exposure to the Organophosphate Pesticide Azamethiphos in the Marine Mollusc Mytilus Edulis." Marine Pollution Bulletin, vol. 54, no. 4, 2007, pp. 396-402.
Canty MN, Hagger JA, Moore RT, et al. Sublethal impact of short term exposure to the organophosphate pesticide azamethiphos in the marine mollusc Mytilus edulis. Mar Pollut Bull. 2007;54(4):396-402.
Canty, M. N., Hagger, J. A., Moore, R. T., Cooper, L., & Galloway, T. S. (2007). Sublethal impact of short term exposure to the organophosphate pesticide azamethiphos in the marine mollusc Mytilus edulis. Marine Pollution Bulletin, 54(4), 396-402.
Canty MN, et al. Sublethal Impact of Short Term Exposure to the Organophosphate Pesticide Azamethiphos in the Marine Mollusc Mytilus Edulis. Mar Pollut Bull. 2007;54(4):396-402. PubMed PMID: 17266995.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sublethal impact of short term exposure to the organophosphate pesticide azamethiphos in the marine mollusc Mytilus edulis. AU - Canty,M N, AU - Hagger,J A, AU - Moore,R T B, AU - Cooper,L, AU - Galloway,T S, Y1 - 2007/01/30/ PY - 2006/07/24/received PY - 2006/11/10/revised PY - 2006/11/13/accepted PY - 2007/2/3/pubmed PY - 2008/8/30/medline PY - 2007/2/3/entrez SP - 396 EP - 402 JF - Marine pollution bulletin JO - Mar Pollut Bull VL - 54 IS - 4 N2 - Concern has been raised that the increased use of pesticides in intensive aquaculture practices may cause adverse sublethal effects to non-target aquatic species. Azamethiphos is an organophosphate (OP) pesticide used to combat sea lice infestations in farmed salmonids. Here, the sublethal impact on the blue mussel, Mytilus edulis, of short term exposure to azamethiphos was determined. The testing regime included biomarkers of exposure (acetylcholinesterase activity), cytotoxicity (neutral red retention), immune function (phagocytic index) and physiological condition (feeding rate). The distribution and sensitivity of M. edulis acetylcholinesterase to inhibition by azamethiphos was first determined, yielding IC(50) values of 0.736 and 1.30 mg l(-1) for gill and haemolymph, respectively. Exposure of mussels to 0.1 mg l(-1) azamethiphos for periods of up to 24h caused a significant reduction in acetylcholinesterase activity in both the haemolymph (P<0.0002) and the gill (P<0.002), alteration in cell viability (P<0.02) and decrease in phagocytic index (P<0.03). The feeding rate remained unaffected. The results support the hypothesis that, in addition to its neurotoxic effects, azamethiphos can modulate haemocyte function and immune defence in M. edulis at environmentally relevant concentrations after only a few hours. SN - 0025-326X UR - https://www.unboundmedicine.com/medline/citation/17266995/Sublethal_impact_of_short_term_exposure_to_the_organophosphate_pesticide_azamethiphos_in_the_marine_mollusc_Mytilus_edulis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0025-326X(06)00499-1 DB - PRIME DP - Unbound Medicine ER -