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New natural intergenotypic (2/5) recombinant of hepatitis C virus.
J Virol. 2007 Apr; 81(8):4357-62.JV

Abstract

A 9.2-kb sequence from a hepatitis C virus (HCV) strain found in southwest France was compared to sequences from reference strains in HCV sequence databases. We found a recombinant virus with genotype 2 at the 5' end and genotype 5 at the 3' end. The crossover point was located between genes NS2 and NS3. Recombination between HCV genotypes must now be considered in studies on HCV epidemiology and evolution and in predictions of the virus response to antiviral therapy. Knowing the location of the recombination point may also be useful for constructing infectious chimeric viruses.

Links

Publisher Full Text
ncbi.nlm.nih.gov
jvi.asm.org
PMC Free PDF

Authors+Show Affiliations

Legrand-Abravanel F
Laboratoire de Virologie, Institut Fédératif de Biologie, INSERM U563, IFR30, 330 Ave. de Grande-Bretagne, TSA 40031, 31059 Toulouse Cédex 9, France.
Claudinon J
No affiliation info available
Nicot F
No affiliation info available
Dubois M
No affiliation info available
Chapuy-Regaud S
No affiliation info available
Sandres-Saune K
No affiliation info available
Pasquier C
No affiliation info available
Izopet J
No affiliation info available

MeSH

Base SequenceFranceGenome, ViralHepacivirusHepatitis CHumansMolecular Sequence DataPhylogenyRNA, ViralRecombination, GeneticSequence Homology

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17267503

Citation

Legrand-Abravanel, Florence, et al. "New Natural Intergenotypic (2/5) Recombinant of Hepatitis C Virus." Journal of Virology, vol. 81, no. 8, 2007, pp. 4357-62.
Legrand-Abravanel F, Claudinon J, Nicot F, et al. New natural intergenotypic (2/5) recombinant of hepatitis C virus. J Virol. 2007;81(8):4357-62.
Legrand-Abravanel, F., Claudinon, J., Nicot, F., Dubois, M., Chapuy-Regaud, S., Sandres-Saune, K., Pasquier, C., & Izopet, J. (2007). New natural intergenotypic (2/5) recombinant of hepatitis C virus. Journal of Virology, 81(8), 4357-62.
Legrand-Abravanel F, et al. New Natural Intergenotypic (2/5) Recombinant of Hepatitis C Virus. J Virol. 2007;81(8):4357-62. PubMed PMID: 17267503.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - New natural intergenotypic (2/5) recombinant of hepatitis C virus. AU - Legrand-Abravanel,Florence, AU - Claudinon,Julie, AU - Nicot,Florence, AU - Dubois,Martine, AU - Chapuy-Regaud,Sabine, AU - Sandres-Saune,Karine, AU - Pasquier,Christophe, AU - Izopet,Jacques, Y1 - 2007/01/31/ PY - 2007/2/3/pubmed PY - 2007/5/19/medline PY - 2007/2/3/entrez SP - 4357 EP - 62 JF - Journal of virology JO - J Virol VL - 81 IS - 8 N2 - A 9.2-kb sequence from a hepatitis C virus (HCV) strain found in southwest France was compared to sequences from reference strains in HCV sequence databases. We found a recombinant virus with genotype 2 at the 5' end and genotype 5 at the 3' end. The crossover point was located between genes NS2 and NS3. Recombination between HCV genotypes must now be considered in studies on HCV epidemiology and evolution and in predictions of the virus response to antiviral therapy. Knowing the location of the recombination point may also be useful for constructing infectious chimeric viruses. SN - 0022-538X UR - https://www.unboundmedicine.com/medline/citation/17267503/New_natural_intergenotypic__2/5__recombinant_of_hepatitis_C_virus_ L2 - http://jvi.asm.org/cgi/pmidlookup?view=long&pmid=17267503 DB - PRIME DP - Unbound Medicine ER -