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Dietary supplementation with flaxseed oil lowers blood pressure in dyslipidaemic patients.
Eur J Clin Nutr. 2007 Oct; 61(10):1201-6.EJ

Abstract

OBJECTIVE

Alpha-linolenic acid (ALA) is the natural precursor of the cardioprotective long-chain n-3 fatty acids. Available data indicate a possible beneficial effect of ALA on cardiovascular disease (CVD), but the response of various CVD risk factors to increased ALA intake is not well characterized. The purpose of the present study was to examine the effect of increased ALA intake on blood pressure in man. DESIGN, SETTING, SUBJECTS AND INTERVENTIONS: We used a prospective, two-group, parallel-arm design to examine the effect of a 12-week dietary supplementation with flaxseed oil, rich in ALA (8 g/day), on blood pressure in middle-aged dyslipidaemic men (n=59). The diet of the control group was supplemented with safflower oil, containing the equivalent n-6 fatty acid (11 g/day linoleic acid (LA); n=28). Arterial blood pressure was measured at the beginning and at the end of the dietary intervention period.

RESULTS

Supplementation with ALA resulted in significantly lower systolic and diastolic blood pressure levels compared with LA (P=0.016 and P=0.011, respectively, from analysis of variance (ANOVA) for repeated measures).

CONCLUSIONS

We observed a hypotensive effect of ALA, which may constitute another mechanism accounting in part for the apparent cardioprotective effect of this n-3 fatty acid.

Authors+Show Affiliations

Department of Nutrition and Dietetics, Harokopio University, Athens, Greece.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17268413

Citation

Paschos, G K., et al. "Dietary Supplementation With Flaxseed Oil Lowers Blood Pressure in Dyslipidaemic Patients." European Journal of Clinical Nutrition, vol. 61, no. 10, 2007, pp. 1201-6.
Paschos GK, Magkos F, Panagiotakos DB, et al. Dietary supplementation with flaxseed oil lowers blood pressure in dyslipidaemic patients. Eur J Clin Nutr. 2007;61(10):1201-6.
Paschos, G. K., Magkos, F., Panagiotakos, D. B., Votteas, V., & Zampelas, A. (2007). Dietary supplementation with flaxseed oil lowers blood pressure in dyslipidaemic patients. European Journal of Clinical Nutrition, 61(10), 1201-6.
Paschos GK, et al. Dietary Supplementation With Flaxseed Oil Lowers Blood Pressure in Dyslipidaemic Patients. Eur J Clin Nutr. 2007;61(10):1201-6. PubMed PMID: 17268413.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary supplementation with flaxseed oil lowers blood pressure in dyslipidaemic patients. AU - Paschos,G K, AU - Magkos,F, AU - Panagiotakos,D B, AU - Votteas,V, AU - Zampelas,A, Y1 - 2007/01/31/ PY - 2007/2/3/pubmed PY - 2008/1/23/medline PY - 2007/2/3/entrez SP - 1201 EP - 6 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 61 IS - 10 N2 - OBJECTIVE: Alpha-linolenic acid (ALA) is the natural precursor of the cardioprotective long-chain n-3 fatty acids. Available data indicate a possible beneficial effect of ALA on cardiovascular disease (CVD), but the response of various CVD risk factors to increased ALA intake is not well characterized. The purpose of the present study was to examine the effect of increased ALA intake on blood pressure in man. DESIGN, SETTING, SUBJECTS AND INTERVENTIONS: We used a prospective, two-group, parallel-arm design to examine the effect of a 12-week dietary supplementation with flaxseed oil, rich in ALA (8 g/day), on blood pressure in middle-aged dyslipidaemic men (n=59). The diet of the control group was supplemented with safflower oil, containing the equivalent n-6 fatty acid (11 g/day linoleic acid (LA); n=28). Arterial blood pressure was measured at the beginning and at the end of the dietary intervention period. RESULTS: Supplementation with ALA resulted in significantly lower systolic and diastolic blood pressure levels compared with LA (P=0.016 and P=0.011, respectively, from analysis of variance (ANOVA) for repeated measures). CONCLUSIONS: We observed a hypotensive effect of ALA, which may constitute another mechanism accounting in part for the apparent cardioprotective effect of this n-3 fatty acid. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/17268413/Dietary_supplementation_with_flaxseed_oil_lowers_blood_pressure_in_dyslipidaemic_patients_ L2 - https://doi.org/10.1038/sj.ejcn.1602631 DB - PRIME DP - Unbound Medicine ER -