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Consumption of trans fats and estimated effects on coronary heart disease in Iran.
Eur J Clin Nutr 2007; 61(8):1004-10EJ

Abstract

OBJECTIVE

To investigate the consumption of industrial trans-fatty acids (TFAs) in Iranian homes and the proportion of coronary heart disease (CHD) events in Iran attributable to such intake.

DESIGN, SETTING AND PARTICIPANTS

The consumption of industrial TFAs was determined using (1) detailed in-home assessments of dietary intake among 7158 urban and rural households containing 35 924 individuals and (2) gas chromatography to determine TFA contents of the most commonly consumed partially hydrogenated oils. The population-attributable risk for CHD owing to TFA consumption was calculated on the basis of (1) documented effects of TFAs on total:high-density lipoprotein (HDL) cholesterol in randomized controlled dietary trials and (2) relationships of TFA intake with incidence of CHD in prospective observational studies.

RESULTS

Partially hydrogenated oils were used extensively for cooking in Iranian homes with average per-person intake of 14 g/1000 kcal. TFAs accounted for 33% of fatty acids in these products, or 4.2% of all calories consumed (12.3 g/day). On the basis of total:HDL cholesterol effects alone, 9% of CHD events would be prevented by replacement of TFA in Iranian homes with cis-unsaturated fats (8% by replacement with saturated fats). On the basis of relationships of TFA intake with CHD incidence in prospective studies, 39% of CHD events would be prevented by replacement of TFA with cis-unsaturated fats (31% by replacement with saturated fats). These population-attributable risks may be overestimates owing to competing risks and because not all the fat used for cooking might actually be consumed. If actual TFA consumption were only half as large, the estimated proportion of CHD events prevented by TFA elimination would be 5% on the basis of total:HDL cholesterol effects and replacement with cis-unsaturated (4% for replacement with saturated fats), and 22% on the basis of prospective studies and replacement with cis-unsaturated fats (17% for replacement with saturated fats). These estimates do not include possible additional benefits derived from replacing TFAs with vegetable oils containing n-3 fatty acids.

CONCLUSIONS

Intake of TFAs is high in Iranian homes and contributes to a sizeable proportion of CHD events. Replacement of partially hydrogenated oils with unhydrogenated oils would likely produce substantial reductions in CHD incidence.

SPONSORSHIP

National Heart, Lung and Blood Institute, National Institutes of Health, USA. National Nutrition & Food Technology Research Institute, Tehran, Iran.

Authors+Show Affiliations

The Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA. dmozaffa@hsph.harvard.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

17268422

Citation

Mozaffarian, D, et al. "Consumption of Trans Fats and Estimated Effects On Coronary Heart Disease in Iran." European Journal of Clinical Nutrition, vol. 61, no. 8, 2007, pp. 1004-10.
Mozaffarian D, Abdollahi M, Campos H, et al. Consumption of trans fats and estimated effects on coronary heart disease in Iran. Eur J Clin Nutr. 2007;61(8):1004-10.
Mozaffarian, D., Abdollahi, M., Campos, H., Houshiarrad, A., & Willett, W. C. (2007). Consumption of trans fats and estimated effects on coronary heart disease in Iran. European Journal of Clinical Nutrition, 61(8), pp. 1004-10.
Mozaffarian D, et al. Consumption of Trans Fats and Estimated Effects On Coronary Heart Disease in Iran. Eur J Clin Nutr. 2007;61(8):1004-10. PubMed PMID: 17268422.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Consumption of trans fats and estimated effects on coronary heart disease in Iran. AU - Mozaffarian,D, AU - Abdollahi,M, AU - Campos,H, AU - Houshiarrad,A, AU - Willett,W C, Y1 - 2007/01/31/ PY - 2007/2/3/pubmed PY - 2007/11/2/medline PY - 2007/2/3/entrez SP - 1004 EP - 10 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 61 IS - 8 N2 - OBJECTIVE: To investigate the consumption of industrial trans-fatty acids (TFAs) in Iranian homes and the proportion of coronary heart disease (CHD) events in Iran attributable to such intake. DESIGN, SETTING AND PARTICIPANTS: The consumption of industrial TFAs was determined using (1) detailed in-home assessments of dietary intake among 7158 urban and rural households containing 35 924 individuals and (2) gas chromatography to determine TFA contents of the most commonly consumed partially hydrogenated oils. The population-attributable risk for CHD owing to TFA consumption was calculated on the basis of (1) documented effects of TFAs on total:high-density lipoprotein (HDL) cholesterol in randomized controlled dietary trials and (2) relationships of TFA intake with incidence of CHD in prospective observational studies. RESULTS: Partially hydrogenated oils were used extensively for cooking in Iranian homes with average per-person intake of 14 g/1000 kcal. TFAs accounted for 33% of fatty acids in these products, or 4.2% of all calories consumed (12.3 g/day). On the basis of total:HDL cholesterol effects alone, 9% of CHD events would be prevented by replacement of TFA in Iranian homes with cis-unsaturated fats (8% by replacement with saturated fats). On the basis of relationships of TFA intake with CHD incidence in prospective studies, 39% of CHD events would be prevented by replacement of TFA with cis-unsaturated fats (31% by replacement with saturated fats). These population-attributable risks may be overestimates owing to competing risks and because not all the fat used for cooking might actually be consumed. If actual TFA consumption were only half as large, the estimated proportion of CHD events prevented by TFA elimination would be 5% on the basis of total:HDL cholesterol effects and replacement with cis-unsaturated (4% for replacement with saturated fats), and 22% on the basis of prospective studies and replacement with cis-unsaturated fats (17% for replacement with saturated fats). These estimates do not include possible additional benefits derived from replacing TFAs with vegetable oils containing n-3 fatty acids. CONCLUSIONS: Intake of TFAs is high in Iranian homes and contributes to a sizeable proportion of CHD events. Replacement of partially hydrogenated oils with unhydrogenated oils would likely produce substantial reductions in CHD incidence. SPONSORSHIP: National Heart, Lung and Blood Institute, National Institutes of Health, USA. National Nutrition & Food Technology Research Institute, Tehran, Iran. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/17268422/Consumption_of_trans_fats_and_estimated_effects_on_coronary_heart_disease_in_Iran_ L2 - http://dx.doi.org/10.1038/sj.ejcn.1602608 DB - PRIME DP - Unbound Medicine ER -