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Meta-analysis: the efficacy of proton pump inhibitors for laryngeal symptoms attributed to gastro-oesophageal reflux disease.
Aliment Pharmacol Ther 2007; 25(4):385-92AP

Abstract

BACKGROUND

Many investigators have proposed an association between gastro-oesophageal reflux disease and laryngo-pharyngeal symptoms, suggesting that medical or surgical therapy for reflux may be useful.

AIM

To perform a meta-analysis assessing the effectiveness of medical or surgical therapy for reflux disease in adult patients with laryngeal or pharyngeal symptoms presumed to be due to gastro-oesophageal reflux disease.

METHODS

Randomized controlled trials comparing medical or surgical treatments for gastro-oesophageal reflux disease against placebo were identified by searching MEDLINE (1966-September 2005), EMBASE (1974-September 2005), the CCRCT (until September 2005) and abstracts from gastroenterology and ENT meetings. The relative risks of reporting symptomatic improvement or resolution of symptoms was evaluated using a random-effects model.

RESULTS

Five studies using high-dose proton pump inhibitor as intervention met the inclusion criteria and were included in the meta-analysis. No surgical studies met inclusion criteria. The pooled relative risk was 1.18 (95% confidence interval: 0.81-1.74). There was no heterogeneity between studies but evidence of significant publication bias. Sub-group analysis performed evaluating Jadad scores and symptom type, did not change the relative risk.

CONCLUSIONS

Therapy with a high-dose proton pump inhibitor is no more effective than placebo in producing symptomatic improvement or resolution of laryngo-pharyngeal symptoms. Further studies are necessary to identify the characteristics of patients that may respond to proton pump inhibitor therapy.

Authors+Show Affiliations

Department of Internal Medicine and Gastroenterology, S.Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.

Pub Type(s)

Comparative Study
Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17269993

Citation

Gatta, L, et al. "Meta-analysis: the Efficacy of Proton Pump Inhibitors for Laryngeal Symptoms Attributed to Gastro-oesophageal Reflux Disease." Alimentary Pharmacology & Therapeutics, vol. 25, no. 4, 2007, pp. 385-92.
Gatta L, Vaira D, Sorrenti G, et al. Meta-analysis: the efficacy of proton pump inhibitors for laryngeal symptoms attributed to gastro-oesophageal reflux disease. Aliment Pharmacol Ther. 2007;25(4):385-92.
Gatta, L., Vaira, D., Sorrenti, G., Zucchini, S., Sama, C., & Vakil, N. (2007). Meta-analysis: the efficacy of proton pump inhibitors for laryngeal symptoms attributed to gastro-oesophageal reflux disease. Alimentary Pharmacology & Therapeutics, 25(4), pp. 385-92.
Gatta L, et al. Meta-analysis: the Efficacy of Proton Pump Inhibitors for Laryngeal Symptoms Attributed to Gastro-oesophageal Reflux Disease. Aliment Pharmacol Ther. 2007 Feb 15;25(4):385-92. PubMed PMID: 17269993.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Meta-analysis: the efficacy of proton pump inhibitors for laryngeal symptoms attributed to gastro-oesophageal reflux disease. AU - Gatta,L, AU - Vaira,D, AU - Sorrenti,G, AU - Zucchini,S, AU - Sama,C, AU - Vakil,N, PY - 2007/2/3/pubmed PY - 2007/11/6/medline PY - 2007/2/3/entrez SP - 385 EP - 92 JF - Alimentary pharmacology & therapeutics JO - Aliment. Pharmacol. Ther. VL - 25 IS - 4 N2 - BACKGROUND: Many investigators have proposed an association between gastro-oesophageal reflux disease and laryngo-pharyngeal symptoms, suggesting that medical or surgical therapy for reflux may be useful. AIM: To perform a meta-analysis assessing the effectiveness of medical or surgical therapy for reflux disease in adult patients with laryngeal or pharyngeal symptoms presumed to be due to gastro-oesophageal reflux disease. METHODS: Randomized controlled trials comparing medical or surgical treatments for gastro-oesophageal reflux disease against placebo were identified by searching MEDLINE (1966-September 2005), EMBASE (1974-September 2005), the CCRCT (until September 2005) and abstracts from gastroenterology and ENT meetings. The relative risks of reporting symptomatic improvement or resolution of symptoms was evaluated using a random-effects model. RESULTS: Five studies using high-dose proton pump inhibitor as intervention met the inclusion criteria and were included in the meta-analysis. No surgical studies met inclusion criteria. The pooled relative risk was 1.18 (95% confidence interval: 0.81-1.74). There was no heterogeneity between studies but evidence of significant publication bias. Sub-group analysis performed evaluating Jadad scores and symptom type, did not change the relative risk. CONCLUSIONS: Therapy with a high-dose proton pump inhibitor is no more effective than placebo in producing symptomatic improvement or resolution of laryngo-pharyngeal symptoms. Further studies are necessary to identify the characteristics of patients that may respond to proton pump inhibitor therapy. SN - 0269-2813 UR - https://www.unboundmedicine.com/medline/citation/17269993/Meta_analysis:_the_efficacy_of_proton_pump_inhibitors_for_laryngeal_symptoms_attributed_to_gastro_oesophageal_reflux_disease_ L2 - https://doi.org/10.1111/j.1365-2036.2006.03213.x DB - PRIME DP - Unbound Medicine ER -