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Meta-analysis: ondansetron for vomiting in acute gastroenteritis in children.
Aliment Pharmacol Ther. 2007 Feb 15; 25(4):393-400.AP

Abstract

BACKGROUND

Vomiting is a common sympton in children with gastroenteritis, but its treatment remains controversial.

AIM

To investigate potential beneficial effects of ondansetron, compared with placebo or no intervention, in treating vomiting during acute gastroenteritis in children.

METHODS

The following electronic databases were searched through August 2006: MEDLINE, EMBASE, CINAHL and The Cochrane Library; additional references were obtained from reviewed articles. Only randomized-controlled trials (RCTs) were included.

RESULTS

Four RCTs involving 490 patients with vomiting during acute gastroenteritis were included. Combined data from three RCTs (n = 466) showed that ondansetron compared with the control significantly increased the chance for vomiting cessation soon after drug administration [relative risk (RR): 1.3, 95% confidence interval (CI): 1.2-1.5, number needed to treat (NNT): 5, 95% CI: 4-8], but this effect was not observed at 24 h (three RCTs, n = 144, RR 1.2, 95% CI: 0.9-1.7). Ondansetron significantly reduced the risk of intravenous rehydration (two RCTs, n = 359, RR 0.4, 95% CI: 0.3-0.7, NNT 7, 95% CI: 5-14). Outcome measures not significantly different after ondansetron treatment were the need for hospitalization and return emergency department visits.

CONCLUSIONS

Despite some clinical benefits, there is insufficient evidence to recommend the routine use of ondansetron for vomiting during acute gastroenteritis in children.

Authors+Show Affiliations

The Second Department of Pediatrics, The Medical University of Warsaw, Warsaw, Poland. hania@ipgate.plNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17269994

Citation

Szajewska, H, et al. "Meta-analysis: Ondansetron for Vomiting in Acute Gastroenteritis in Children." Alimentary Pharmacology & Therapeutics, vol. 25, no. 4, 2007, pp. 393-400.
Szajewska H, Gieruszczak-Białek D, Dylag M. Meta-analysis: ondansetron for vomiting in acute gastroenteritis in children. Aliment Pharmacol Ther. 2007;25(4):393-400.
Szajewska, H., Gieruszczak-Białek, D., & Dylag, M. (2007). Meta-analysis: ondansetron for vomiting in acute gastroenteritis in children. Alimentary Pharmacology & Therapeutics, 25(4), 393-400.
Szajewska H, Gieruszczak-Białek D, Dylag M. Meta-analysis: Ondansetron for Vomiting in Acute Gastroenteritis in Children. Aliment Pharmacol Ther. 2007 Feb 15;25(4):393-400. PubMed PMID: 17269994.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Meta-analysis: ondansetron for vomiting in acute gastroenteritis in children. AU - Szajewska,H, AU - Gieruszczak-Białek,D, AU - Dylag,M, PY - 2007/2/3/pubmed PY - 2007/11/6/medline PY - 2007/2/3/entrez SP - 393 EP - 400 JF - Alimentary pharmacology & therapeutics JO - Aliment Pharmacol Ther VL - 25 IS - 4 N2 - BACKGROUND: Vomiting is a common sympton in children with gastroenteritis, but its treatment remains controversial. AIM: To investigate potential beneficial effects of ondansetron, compared with placebo or no intervention, in treating vomiting during acute gastroenteritis in children. METHODS: The following electronic databases were searched through August 2006: MEDLINE, EMBASE, CINAHL and The Cochrane Library; additional references were obtained from reviewed articles. Only randomized-controlled trials (RCTs) were included. RESULTS: Four RCTs involving 490 patients with vomiting during acute gastroenteritis were included. Combined data from three RCTs (n = 466) showed that ondansetron compared with the control significantly increased the chance for vomiting cessation soon after drug administration [relative risk (RR): 1.3, 95% confidence interval (CI): 1.2-1.5, number needed to treat (NNT): 5, 95% CI: 4-8], but this effect was not observed at 24 h (three RCTs, n = 144, RR 1.2, 95% CI: 0.9-1.7). Ondansetron significantly reduced the risk of intravenous rehydration (two RCTs, n = 359, RR 0.4, 95% CI: 0.3-0.7, NNT 7, 95% CI: 5-14). Outcome measures not significantly different after ondansetron treatment were the need for hospitalization and return emergency department visits. CONCLUSIONS: Despite some clinical benefits, there is insufficient evidence to recommend the routine use of ondansetron for vomiting during acute gastroenteritis in children. SN - 0269-2813 UR - https://www.unboundmedicine.com/medline/citation/17269994/Meta_analysis:_ondansetron_for_vomiting_in_acute_gastroenteritis_in_children_ L2 - https://doi.org/10.1111/j.1365-2036.2006.03231.x DB - PRIME DP - Unbound Medicine ER -