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Early glaucoma detection using the Humphrey Matrix Perimeter, GDx VCC, Stratus OCT, and retinal nerve fiber layer photography.
Ophthalmology. 2007 Feb; 114(2):210-5.O

Abstract

PURPOSE

To compare the effectiveness of Humphrey Matrix perimetry, GDx VCC, Stratus OCT, and retinal nerve fiber layer (RNFL) photography using the Heidelberg Retina Angiograph 1 (HRA1) for early glaucoma detection.

DESIGN

Cross-sectional comparative study.

PARTICIPANTS

Seventy-two primary open-angle glaucoma patients with early-stage visual field defects and 48 healthy controls were included.

METHODS

Measurements using Humphrey Matrix perimetry, GDx VCC, Stratus OCT, and RNFL photography using HRA1, as well as standard automated perimetry, were obtained. We constructed receiver operating characteristic (ROC) curves for all available parameters and calculated the area under the ROC curves (AUC) to seek the best discriminating parameter of each test. Subsequently, the ROC curves were calculated for the combinations of the best discriminating parameters of each test to seek the most effective combination for early glaucoma detection.

MAIN OUTCOME MEASURE

The AUC for various parameters of Humphrey Matrix perimetry, GDx VCC, Stratus OCT, and RNFL photography using HRA1.

RESULTS

The AUCs of Humphrey Matrix perimetry, GDx VCC, Stratus OCT, and RNFL photography using HRA1 with the best discriminating parameter were 0.990, 0.906, 0.794, and 0.751, respectively. The AUC of the following best combination was 0.972, more than 5 points depressed below the level of 5% on the pattern deviation plot from Humphrey Matrix perimetry, and the nerve fiber indicator was larger than 20 from GDx VCC.

CONCLUSIONS

The AUC of the Humphrey Matrix perimetry was greater than that of the GDx VCC, Stratus OCT, and RNFL photography using HRA1.

Authors+Show Affiliations

Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

17270671

Citation

Hong, Samin, et al. "Early Glaucoma Detection Using the Humphrey Matrix Perimeter, GDx VCC, Stratus OCT, and Retinal Nerve Fiber Layer Photography." Ophthalmology, vol. 114, no. 2, 2007, pp. 210-5.
Hong S, Ahn H, Ha SJ, et al. Early glaucoma detection using the Humphrey Matrix Perimeter, GDx VCC, Stratus OCT, and retinal nerve fiber layer photography. Ophthalmology. 2007;114(2):210-5.
Hong, S., Ahn, H., Ha, S. J., Yeom, H. Y., Seong, G. J., & Hong, Y. J. (2007). Early glaucoma detection using the Humphrey Matrix Perimeter, GDx VCC, Stratus OCT, and retinal nerve fiber layer photography. Ophthalmology, 114(2), 210-5.
Hong S, et al. Early Glaucoma Detection Using the Humphrey Matrix Perimeter, GDx VCC, Stratus OCT, and Retinal Nerve Fiber Layer Photography. Ophthalmology. 2007;114(2):210-5. PubMed PMID: 17270671.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Early glaucoma detection using the Humphrey Matrix Perimeter, GDx VCC, Stratus OCT, and retinal nerve fiber layer photography. AU - Hong,Samin, AU - Ahn,Hyunseok, AU - Ha,Seung Joo, AU - Yeom,Ho Yeop, AU - Seong,Gong Je, AU - Hong,Young Jae, PY - 2005/10/02/received PY - 2006/09/06/revised PY - 2006/09/07/accepted PY - 2007/2/3/pubmed PY - 2007/2/21/medline PY - 2007/2/3/entrez SP - 210 EP - 5 JF - Ophthalmology JO - Ophthalmology VL - 114 IS - 2 N2 - PURPOSE: To compare the effectiveness of Humphrey Matrix perimetry, GDx VCC, Stratus OCT, and retinal nerve fiber layer (RNFL) photography using the Heidelberg Retina Angiograph 1 (HRA1) for early glaucoma detection. DESIGN: Cross-sectional comparative study. PARTICIPANTS: Seventy-two primary open-angle glaucoma patients with early-stage visual field defects and 48 healthy controls were included. METHODS: Measurements using Humphrey Matrix perimetry, GDx VCC, Stratus OCT, and RNFL photography using HRA1, as well as standard automated perimetry, were obtained. We constructed receiver operating characteristic (ROC) curves for all available parameters and calculated the area under the ROC curves (AUC) to seek the best discriminating parameter of each test. Subsequently, the ROC curves were calculated for the combinations of the best discriminating parameters of each test to seek the most effective combination for early glaucoma detection. MAIN OUTCOME MEASURE: The AUC for various parameters of Humphrey Matrix perimetry, GDx VCC, Stratus OCT, and RNFL photography using HRA1. RESULTS: The AUCs of Humphrey Matrix perimetry, GDx VCC, Stratus OCT, and RNFL photography using HRA1 with the best discriminating parameter were 0.990, 0.906, 0.794, and 0.751, respectively. The AUC of the following best combination was 0.972, more than 5 points depressed below the level of 5% on the pattern deviation plot from Humphrey Matrix perimetry, and the nerve fiber indicator was larger than 20 from GDx VCC. CONCLUSIONS: The AUC of the Humphrey Matrix perimetry was greater than that of the GDx VCC, Stratus OCT, and RNFL photography using HRA1. SN - 1549-4713 UR - https://www.unboundmedicine.com/medline/citation/17270671/Early_glaucoma_detection_using_the_Humphrey_Matrix_Perimeter_GDx_VCC_Stratus_OCT_and_retinal_nerve_fiber_layer_photography_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-6420(06)01322-4 DB - PRIME DP - Unbound Medicine ER -