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Hallmarks of protein oxidative damage in neurodegenerative diseases: focus on Alzheimer's disease.
Amino Acids 2007; 32(4):553-9AA

Abstract

The pathogenesis of several neurodegenerative diseases, including Alzheimer's disease, has been linked to a condition of oxidative and nitrosative stress, arising from the imbalance between increased reactive oxygen species (ROS) and reactive nitrogen species (RNS) production and antioxidant defences or efficiency of repair or removal systems. The effects of free radicals are expressed by the accumulation of oxidative damage to biomolecules: nucleic acids, lipids and proteins. In this review we focused our attention on the large body of evidence of oxidative damage to protein in Alzheimer's disease brain and peripheral cells as well as in their role in signalling pathways. The progress in the understanding of the molecular alterations underlying Alzheimer's disease will be useful in developing successful preventive and therapeutic strategies, since available drugs can only temporarily stabilize the disease, but are not able to block the neurodegenerative process.

Authors+Show Affiliations

Institute of Biochemistry and Molecular Biology I, Heinrich-Heine University, Düsseldorf, Germany.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

17273806

Citation

Polidori, M C., et al. "Hallmarks of Protein Oxidative Damage in Neurodegenerative Diseases: Focus On Alzheimer's Disease." Amino Acids, vol. 32, no. 4, 2007, pp. 553-9.
Polidori MC, Griffiths HR, Mariani E, et al. Hallmarks of protein oxidative damage in neurodegenerative diseases: focus on Alzheimer's disease. Amino Acids. 2007;32(4):553-9.
Polidori, M. C., Griffiths, H. R., Mariani, E., & Mecocci, P. (2007). Hallmarks of protein oxidative damage in neurodegenerative diseases: focus on Alzheimer's disease. Amino Acids, 32(4), pp. 553-9.
Polidori MC, et al. Hallmarks of Protein Oxidative Damage in Neurodegenerative Diseases: Focus On Alzheimer's Disease. Amino Acids. 2007;32(4):553-9. PubMed PMID: 17273806.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hallmarks of protein oxidative damage in neurodegenerative diseases: focus on Alzheimer's disease. AU - Polidori,M C, AU - Griffiths,H R, AU - Mariani,E, AU - Mecocci,P, Y1 - 2007/02/02/ PY - 2006/03/23/received PY - 2006/06/30/accepted PY - 2007/2/3/pubmed PY - 2007/10/10/medline PY - 2007/2/3/entrez SP - 553 EP - 9 JF - Amino acids JO - Amino Acids VL - 32 IS - 4 N2 - The pathogenesis of several neurodegenerative diseases, including Alzheimer's disease, has been linked to a condition of oxidative and nitrosative stress, arising from the imbalance between increased reactive oxygen species (ROS) and reactive nitrogen species (RNS) production and antioxidant defences or efficiency of repair or removal systems. The effects of free radicals are expressed by the accumulation of oxidative damage to biomolecules: nucleic acids, lipids and proteins. In this review we focused our attention on the large body of evidence of oxidative damage to protein in Alzheimer's disease brain and peripheral cells as well as in their role in signalling pathways. The progress in the understanding of the molecular alterations underlying Alzheimer's disease will be useful in developing successful preventive and therapeutic strategies, since available drugs can only temporarily stabilize the disease, but are not able to block the neurodegenerative process. SN - 0939-4451 UR - https://www.unboundmedicine.com/medline/citation/17273806/Hallmarks_of_protein_oxidative_damage_in_neurodegenerative_diseases:_focus_on_Alzheimer's_disease_ L2 - https://dx.doi.org/10.1007/s00726-006-0431-x DB - PRIME DP - Unbound Medicine ER -