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Antinociceptive and antiinflammatory activities of pine (Pinus densiflora) pollen extract.
Phytother Res. 2007 May; 21(5):471-5.PR

Abstract

The study aimed to evaluate the antinociceptive and antiinflammatory activity of pine (Pinus densiflora) pollen in mice. The antinociceptive activity was determined using acetic acid-induced abdominal constriction and formalin-induced licking, and the hot plate test. Antiinflammatory effects were evaluated using carrageenan- and formalin-induced paw edema, and arachidonic acid-induced ear edema in mice. The ethanol extract of pine pollen (100 and 200 mg/kg, p.o.) produced a significant inhibition of both phases of the formalin pain test in mice, a reduction in mouse writhing induced by acetic acid and an elevation of the pain threshold in the hot plate test in mice. The pine pollen extract also produced a significant inhibition of carrageenan- and formalin-induced paw edema as well as arachidonic acid-induced ear edema in mice. The inhibitions were similar to those produced by aminopyrine and indomethacin, p.o. The different polyphenols found in pine pollen could account for the antinociceptive and antiinflammatory actions. The results obtained indicate that the extract possesses analgesic and antiinflammatory effects.

Authors+Show Affiliations

Department of Food and Nutrition, Kyunghee University, Hoegi-dong, Dongdaemun-gu, Seoul, Korea. cheunmi@hanmail.net

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17273982

Citation

Choi, Eun-Mi. "Antinociceptive and Antiinflammatory Activities of Pine (Pinus Densiflora) Pollen Extract." Phytotherapy Research : PTR, vol. 21, no. 5, 2007, pp. 471-5.
Choi EM. Antinociceptive and antiinflammatory activities of pine (Pinus densiflora) pollen extract. Phytother Res. 2007;21(5):471-5.
Choi, E. M. (2007). Antinociceptive and antiinflammatory activities of pine (Pinus densiflora) pollen extract. Phytotherapy Research : PTR, 21(5), 471-5.
Choi EM. Antinociceptive and Antiinflammatory Activities of Pine (Pinus Densiflora) Pollen Extract. Phytother Res. 2007;21(5):471-5. PubMed PMID: 17273982.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antinociceptive and antiinflammatory activities of pine (Pinus densiflora) pollen extract. A1 - Choi,Eun-Mi, PY - 2007/2/3/pubmed PY - 2007/7/10/medline PY - 2007/2/3/entrez SP - 471 EP - 5 JF - Phytotherapy research : PTR JO - Phytother Res VL - 21 IS - 5 N2 - The study aimed to evaluate the antinociceptive and antiinflammatory activity of pine (Pinus densiflora) pollen in mice. The antinociceptive activity was determined using acetic acid-induced abdominal constriction and formalin-induced licking, and the hot plate test. Antiinflammatory effects were evaluated using carrageenan- and formalin-induced paw edema, and arachidonic acid-induced ear edema in mice. The ethanol extract of pine pollen (100 and 200 mg/kg, p.o.) produced a significant inhibition of both phases of the formalin pain test in mice, a reduction in mouse writhing induced by acetic acid and an elevation of the pain threshold in the hot plate test in mice. The pine pollen extract also produced a significant inhibition of carrageenan- and formalin-induced paw edema as well as arachidonic acid-induced ear edema in mice. The inhibitions were similar to those produced by aminopyrine and indomethacin, p.o. The different polyphenols found in pine pollen could account for the antinociceptive and antiinflammatory actions. The results obtained indicate that the extract possesses analgesic and antiinflammatory effects. SN - 0951-418X UR - https://www.unboundmedicine.com/medline/citation/17273982/Antinociceptive_and_antiinflammatory_activities_of_pine__Pinus_densiflora__pollen_extract_ L2 - https://doi.org/10.1002/ptr.2103 DB - PRIME DP - Unbound Medicine ER -