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Survival in patients with synovial sarcoma of the head and neck: association with tumor location, size, and extension.
Head Neck. 2007 Aug; 29(8):731-40.HN

Abstract

BACKGROUND

The medical literature on synovial sarcoma (SS) of the head and neck region is limited. Thus, we determined whether clinical characteristics and treatment were associated with recurrence and survival rates in patients with SS of the head and neck.

METHODS

We retrospectively identified patients with a pathologic diagnosis of SS of the head and neck at our institution (a large tertiary comprehensive cancer center) and compared recurrence and survival rates by clinical characteristics and treatment.

RESULTS

Forty patients with SS of the head and neck were identified from 1945 to 2004 (first case in 1968), representing <5% of all head and neck sarcomas seen at our institution during this time period. Twenty-three patients (58%) had the monophasic histologic subtype, 15 (38%) biphasic, and 2 unspecified. Most patients were male (73%), with a median age of 29 years. SS tumors were most commonly located in the neck (60%); thus, the most common symptoms were a neck mass and neck pain. No patients reported a history of radiation exposure. Higher disease-specific and overall survival rates were associated with upper aerodigestive tract location, tumors of < or =5 cm, and tumors did not extend into bone. Patients treated with surgery and adjuvant radiotherapy had higher survival and lower recurrence rates than did those treated with surgery alone or a combination of surgery, radiotherapy, and chemotherapy. This difference was not significant, and the subgroups were small, with substantial confounding by adverse prognostic factors.

CONCLUSIONS

SS of the head and neck is extremely rare, and our results should be viewed with caution given the relatively small group size and treatment over a 36-year period. Survival rates were associated with tumor location, size, and extension. Treatment of SS of the head and neck should be directed toward complete surgical resection. Given the known sensitivity of SS to contemporary chemotherapy, a multimodality approach should be considered in the perioperative setting, especially in high risk patients.

Authors+Show Affiliations

Department of Head and Neck Surgery, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

17274049

Citation

Harb, William J., et al. "Survival in Patients With Synovial Sarcoma of the Head and Neck: Association With Tumor Location, Size, and Extension." Head & Neck, vol. 29, no. 8, 2007, pp. 731-40.
Harb WJ, Luna MA, Patel SR, et al. Survival in patients with synovial sarcoma of the head and neck: association with tumor location, size, and extension. Head Neck. 2007;29(8):731-40.
Harb, W. J., Luna, M. A., Patel, S. R., Ballo, M. T., Roberts, D. B., & Sturgis, E. M. (2007). Survival in patients with synovial sarcoma of the head and neck: association with tumor location, size, and extension. Head & Neck, 29(8), 731-40.
Harb WJ, et al. Survival in Patients With Synovial Sarcoma of the Head and Neck: Association With Tumor Location, Size, and Extension. Head Neck. 2007;29(8):731-40. PubMed PMID: 17274049.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Survival in patients with synovial sarcoma of the head and neck: association with tumor location, size, and extension. AU - Harb,William J, AU - Luna,Mario A, AU - Patel,Shreyaskumar R, AU - Ballo,Matthew T, AU - Roberts,Dianna B, AU - Sturgis,Erich M, PY - 2007/2/3/pubmed PY - 2007/11/6/medline PY - 2007/2/3/entrez SP - 731 EP - 40 JF - Head & neck JO - Head Neck VL - 29 IS - 8 N2 - BACKGROUND: The medical literature on synovial sarcoma (SS) of the head and neck region is limited. Thus, we determined whether clinical characteristics and treatment were associated with recurrence and survival rates in patients with SS of the head and neck. METHODS: We retrospectively identified patients with a pathologic diagnosis of SS of the head and neck at our institution (a large tertiary comprehensive cancer center) and compared recurrence and survival rates by clinical characteristics and treatment. RESULTS: Forty patients with SS of the head and neck were identified from 1945 to 2004 (first case in 1968), representing <5% of all head and neck sarcomas seen at our institution during this time period. Twenty-three patients (58%) had the monophasic histologic subtype, 15 (38%) biphasic, and 2 unspecified. Most patients were male (73%), with a median age of 29 years. SS tumors were most commonly located in the neck (60%); thus, the most common symptoms were a neck mass and neck pain. No patients reported a history of radiation exposure. Higher disease-specific and overall survival rates were associated with upper aerodigestive tract location, tumors of < or =5 cm, and tumors did not extend into bone. Patients treated with surgery and adjuvant radiotherapy had higher survival and lower recurrence rates than did those treated with surgery alone or a combination of surgery, radiotherapy, and chemotherapy. This difference was not significant, and the subgroups were small, with substantial confounding by adverse prognostic factors. CONCLUSIONS: SS of the head and neck is extremely rare, and our results should be viewed with caution given the relatively small group size and treatment over a 36-year period. Survival rates were associated with tumor location, size, and extension. Treatment of SS of the head and neck should be directed toward complete surgical resection. Given the known sensitivity of SS to contemporary chemotherapy, a multimodality approach should be considered in the perioperative setting, especially in high risk patients. SN - 1043-3074 UR - https://www.unboundmedicine.com/medline/citation/17274049/Survival_in_patients_with_synovial_sarcoma_of_the_head_and_neck:_association_with_tumor_location_size_and_extension_ L2 - https://doi.org/10.1002/hed.20564 DB - PRIME DP - Unbound Medicine ER -