Tags

Type your tag names separated by a space and hit enter

Copper imbalance and oxidative stress in neurodegeneration.

Abstract

Much experimental evidence demonstrates that the increased production of free radicals and oxidative damage due to alterations in copper homeostasis (because of either deficit or excess or aberrant coordination of the metal) are involved in the neurodegenerative processes occurring in many disorders of the central nervous system. This review outlines the systems that are involved in copper homeostasis and in the control of copper redox reactivity. The mechanisms underlying neurodegeneration in the acknowledged genetic disturbances of copper homeostasis, namely Menkes' and Wilson's diseases, and the involvement of copper in the aetiology of the major neurodegenerative disease of the aging brain, Alzheimer's disease, will be described, with particular focus on oxidative stress.

Authors+Show Affiliations

,

Department of Biology, "Tor Vergata" University of Rome, Italy. luisa.rossi@uniroma2.it

, ,

Source

MeSH

Alzheimer Disease
Amyloid beta-Peptides
Brain
Cation Transport Proteins
Copper
Hepatolenticular Degeneration
Homeostasis
Humans
Menkes Kinky Hair Syndrome
Neurodegenerative Diseases
Oxidative Stress
Prions
Superoxide Dismutase

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

17274527

Citation

Rossi, Luisa, et al. "Copper Imbalance and Oxidative Stress in Neurodegeneration." The Italian Journal of Biochemistry, vol. 55, no. 3-4, 2006, pp. 212-21.
Rossi L, Arciello M, Capo C, et al. Copper imbalance and oxidative stress in neurodegeneration. Ital J Biochem. 2006;55(3-4):212-21.
Rossi, L., Arciello, M., Capo, C., & Rotilio, G. (2006). Copper imbalance and oxidative stress in neurodegeneration. The Italian Journal of Biochemistry, 55(3-4), pp. 212-21.
Rossi L, et al. Copper Imbalance and Oxidative Stress in Neurodegeneration. Ital J Biochem. 2006;55(3-4):212-21. PubMed PMID: 17274527.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Copper imbalance and oxidative stress in neurodegeneration. AU - Rossi,Luisa, AU - Arciello,Mario, AU - Capo,Concetta, AU - Rotilio,Giuseppe, PY - 2007/2/6/pubmed PY - 2007/2/21/medline PY - 2007/2/6/entrez SP - 212 EP - 21 JF - The Italian journal of biochemistry JO - Ital. J. Biochem. VL - 55 IS - 3-4 N2 - Much experimental evidence demonstrates that the increased production of free radicals and oxidative damage due to alterations in copper homeostasis (because of either deficit or excess or aberrant coordination of the metal) are involved in the neurodegenerative processes occurring in many disorders of the central nervous system. This review outlines the systems that are involved in copper homeostasis and in the control of copper redox reactivity. The mechanisms underlying neurodegeneration in the acknowledged genetic disturbances of copper homeostasis, namely Menkes' and Wilson's diseases, and the involvement of copper in the aetiology of the major neurodegenerative disease of the aging brain, Alzheimer's disease, will be described, with particular focus on oxidative stress. SN - 0021-2938 UR - https://www.unboundmedicine.com/medline/citation/17274527/Copper_imbalance_and_oxidative_stress_in_neurodegeneration_ L2 - https://medlineplus.gov/degenerativenervediseases.html DB - PRIME DP - Unbound Medicine ER -