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The endocannabinoid system in neurodegeneration.
Ital J Biochem 2006 Sep-Dec; 55(3-4):283-9IJ

Abstract

Endocannabinoids are bioactive lipids, that comprise amides, esters and ethers of long chain polyunsaturated fatty acids. Anandamide (N-arachidonoylethanolamine; AEA) and 2-arachidonoylglycerol (2-AG) are the best studied endocannabinoids, and act as agonists of cannabinoid receptors. Thus, AEA and 2-AG mimic several pharmacological effects of the exogenous cannabinoid delta9-tetrahydrocannabinol, the psychoactive principle of hashish and marijuana. It is known that the activity of endocannabinoids at their receptors is limited by cellular uptake through specific membrane transporters, followed by intracellular degradation by a fatty acid amide hydrolase (for AEA and partly 2-AG) or by a monoacylglycerol lipase (for 2-AG). Together with AEA, 2-AG and congeners, the proteins that bind, transport and metabolize these lipids form the "endocannabinoid system". This new system will be briefly presented in this review, in order to put in a better perspective the role of the endocannabinoid pathway in neurodegenerative disorders, like Parkinson's disease, Huntington's disease, and multiple sclerosis. In addition, the potential exploitation of antagonists of endocannabinoid receptors, or of inhibitors of endocannabinoid metabolism, as next-generation therapeutics will be discussed.

Authors+Show Affiliations

Department of Biomedical Sciences, University of Teramo, Teramo, Italy.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

17274532

Citation

Battista, Natalia, et al. "The Endocannabinoid System in Neurodegeneration." The Italian Journal of Biochemistry, vol. 55, no. 3-4, 2006, pp. 283-9.
Battista N, Fezza F, Finazzi-Agrò A, et al. The endocannabinoid system in neurodegeneration. Ital J Biochem. 2006;55(3-4):283-9.
Battista, N., Fezza, F., Finazzi-Agrò, A., & Maccarrone, M. (2006). The endocannabinoid system in neurodegeneration. The Italian Journal of Biochemistry, 55(3-4), pp. 283-9.
Battista N, et al. The Endocannabinoid System in Neurodegeneration. Ital J Biochem. 2006;55(3-4):283-9. PubMed PMID: 17274532.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The endocannabinoid system in neurodegeneration. AU - Battista,Natalia, AU - Fezza,Filomena, AU - Finazzi-Agrò,Alessandro, AU - Maccarrone,Mauro, PY - 2007/2/6/pubmed PY - 2007/2/21/medline PY - 2007/2/6/entrez SP - 283 EP - 9 JF - The Italian journal of biochemistry JO - Ital. J. Biochem. VL - 55 IS - 3-4 N2 - Endocannabinoids are bioactive lipids, that comprise amides, esters and ethers of long chain polyunsaturated fatty acids. Anandamide (N-arachidonoylethanolamine; AEA) and 2-arachidonoylglycerol (2-AG) are the best studied endocannabinoids, and act as agonists of cannabinoid receptors. Thus, AEA and 2-AG mimic several pharmacological effects of the exogenous cannabinoid delta9-tetrahydrocannabinol, the psychoactive principle of hashish and marijuana. It is known that the activity of endocannabinoids at their receptors is limited by cellular uptake through specific membrane transporters, followed by intracellular degradation by a fatty acid amide hydrolase (for AEA and partly 2-AG) or by a monoacylglycerol lipase (for 2-AG). Together with AEA, 2-AG and congeners, the proteins that bind, transport and metabolize these lipids form the "endocannabinoid system". This new system will be briefly presented in this review, in order to put in a better perspective the role of the endocannabinoid pathway in neurodegenerative disorders, like Parkinson's disease, Huntington's disease, and multiple sclerosis. In addition, the potential exploitation of antagonists of endocannabinoid receptors, or of inhibitors of endocannabinoid metabolism, as next-generation therapeutics will be discussed. SN - 0021-2938 UR - https://www.unboundmedicine.com/medline/citation/17274532/The_endocannabinoid_system_in_neurodegeneration_ L2 - https://medlineplus.gov/degenerativenervediseases.html DB - PRIME DP - Unbound Medicine ER -