Tags

Type your tag names separated by a space and hit enter

Cardiovascular risk factors and the long-term incidence of age-related macular degeneration: the Blue Mountains Eye Study.
Ophthalmology 2007; 114(6):1143-50O

Abstract

PURPOSE

To assess the relationship between cardiovascular disease and cardiovascular risk factors, other than smoking, and risk of long-term incident age-related macular degeneration (AMD).

DESIGN

Population-based cohort study.

PARTICIPANTS

There were 3654 baseline (1992-1994) participants aged > or = 49 years included in the Blue Mountains region, west of Sydney, Australia. Of these, 2335 (75% of survivors) were reexamined after 5 years (1997-1999) and 1952 (76% of survivors) after 10 years (2002-2004).

METHODS

Stereoscopic color fundus photographs were graded using the Wisconsin Age-related Maculopathy Grading System. History, physical examination, and fasting blood samples provided data on possible risk factors. Age-related macular degeneration incidence was calculated using the Kaplan-Meier survival approach. Discrete linear logistic models were used to assess risk of incident AMD. Relative risks (RR) and 95% confidence intervals (CI) are presented after adjusting for age, gender, smoking, and other risk factors.

MAIN OUTCOME MEASURE

Incident early and late AMD.

RESULTS

Increasing high-density lipoprotein (HDL) cholesterol was inversely related to incident late AMD (RR per standard deviation [SD] increase, 0.74; 95% CI, 0.56-0.99). Elevated total/HDL cholesterol ratio predicted late AMD (RR per SD increase, 1.35; 95% CI, 1.07-1.70) and geographic atrophy (GA; RR per SD, 1.63; 95% CI, 1.18-2.25). Diabetes predicted incident GA (RR, 3.89; 95% CI, 1.36-11.08), but not neovascular AMD. History of stroke (RR 2.01; 95% CI, 1.12-3.58), or any cardiovascular disease (stroke, myocardial infarction, or angina; RR, 1.57; 95% CI, 1.13-2.16) predicted incident early AMD and incident indistinct soft or reticular drusen (RR, 2.38; 95% CI, 1.33-4.27 for stroke; RR, 1.80; 95% CI, 1.28-2.52 for any cardiovascular disease). Neither pulse pressure, systolic or diastolic blood pressure, or presence of hypertension at baseline were associated with incident AMD.

CONCLUSIONS

Our findings provide some evidence of links between cardiovascular risk factors and AMD. Further prospective evaluation of these relationships is warranted, as these findings could have therapeutic implications.

Authors+Show Affiliations

Centre for Vision Research, Department of Ophthalmology, Westmead Millennium Institute, University of Sydney, Westmead, Australia.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17275090

Citation

Tan, Jennifer S L., et al. "Cardiovascular Risk Factors and the Long-term Incidence of Age-related Macular Degeneration: the Blue Mountains Eye Study." Ophthalmology, vol. 114, no. 6, 2007, pp. 1143-50.
Tan JS, Mitchell P, Smith W, et al. Cardiovascular risk factors and the long-term incidence of age-related macular degeneration: the Blue Mountains Eye Study. Ophthalmology. 2007;114(6):1143-50.
Tan, J. S., Mitchell, P., Smith, W., & Wang, J. J. (2007). Cardiovascular risk factors and the long-term incidence of age-related macular degeneration: the Blue Mountains Eye Study. Ophthalmology, 114(6), pp. 1143-50.
Tan JS, et al. Cardiovascular Risk Factors and the Long-term Incidence of Age-related Macular Degeneration: the Blue Mountains Eye Study. Ophthalmology. 2007;114(6):1143-50. PubMed PMID: 17275090.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cardiovascular risk factors and the long-term incidence of age-related macular degeneration: the Blue Mountains Eye Study. AU - Tan,Jennifer S L, AU - Mitchell,Paul, AU - Smith,Wayne, AU - Wang,Jie Jin, Y1 - 2007/02/01/ PY - 2006/07/10/received PY - 2006/09/21/revised PY - 2006/09/26/accepted PY - 2007/2/6/pubmed PY - 2007/6/20/medline PY - 2007/2/6/entrez SP - 1143 EP - 50 JF - Ophthalmology JO - Ophthalmology VL - 114 IS - 6 N2 - PURPOSE: To assess the relationship between cardiovascular disease and cardiovascular risk factors, other than smoking, and risk of long-term incident age-related macular degeneration (AMD). DESIGN: Population-based cohort study. PARTICIPANTS: There were 3654 baseline (1992-1994) participants aged > or = 49 years included in the Blue Mountains region, west of Sydney, Australia. Of these, 2335 (75% of survivors) were reexamined after 5 years (1997-1999) and 1952 (76% of survivors) after 10 years (2002-2004). METHODS: Stereoscopic color fundus photographs were graded using the Wisconsin Age-related Maculopathy Grading System. History, physical examination, and fasting blood samples provided data on possible risk factors. Age-related macular degeneration incidence was calculated using the Kaplan-Meier survival approach. Discrete linear logistic models were used to assess risk of incident AMD. Relative risks (RR) and 95% confidence intervals (CI) are presented after adjusting for age, gender, smoking, and other risk factors. MAIN OUTCOME MEASURE: Incident early and late AMD. RESULTS: Increasing high-density lipoprotein (HDL) cholesterol was inversely related to incident late AMD (RR per standard deviation [SD] increase, 0.74; 95% CI, 0.56-0.99). Elevated total/HDL cholesterol ratio predicted late AMD (RR per SD increase, 1.35; 95% CI, 1.07-1.70) and geographic atrophy (GA; RR per SD, 1.63; 95% CI, 1.18-2.25). Diabetes predicted incident GA (RR, 3.89; 95% CI, 1.36-11.08), but not neovascular AMD. History of stroke (RR 2.01; 95% CI, 1.12-3.58), or any cardiovascular disease (stroke, myocardial infarction, or angina; RR, 1.57; 95% CI, 1.13-2.16) predicted incident early AMD and incident indistinct soft or reticular drusen (RR, 2.38; 95% CI, 1.33-4.27 for stroke; RR, 1.80; 95% CI, 1.28-2.52 for any cardiovascular disease). Neither pulse pressure, systolic or diastolic blood pressure, or presence of hypertension at baseline were associated with incident AMD. CONCLUSIONS: Our findings provide some evidence of links between cardiovascular risk factors and AMD. Further prospective evaluation of these relationships is warranted, as these findings could have therapeutic implications. SN - 1549-4713 UR - https://www.unboundmedicine.com/medline/citation/17275090/Cardiovascular_risk_factors_and_the_long_term_incidence_of_age_related_macular_degeneration:_the_Blue_Mountains_Eye_Study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-6420(06)01451-5 DB - PRIME DP - Unbound Medicine ER -