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The effects of black cohosh therapies on lipids, fibrinogen, glucose and insulin.
Maturitas. 2007 Jun 20; 57(2):195-204.M

Abstract

OBJECTIVE

Black cohosh (Actaea racemosa) is an herb commonly used to treat menopausal symptoms. Little is known about its effect on other physiologic parameters that could result in untoward events. This study examines the effect of black cohosh on lipids, fibrinogen, glucose and insulin.

METHODS

Three hundred and fifty-one, 45-55 years old, peri or post-menopausal women experiencing vasomotor symptoms participated in a 3-month, double blind trial with randomization to: (1) black cohosh (160 mg daily); (2) multibotanical including black cohosh (200 mg daily); (3) multibotanical plus soy diet counseling; (4) conjugated equine estrogen .625 mg, with or without medroxyprogesterone acetate 2.5mg daily, for women with or without a uterus, respectively; (5) placebo. Baseline and month 3 total cholesterol, high density lipoprotein (HDL) cholesterol, low density lipoprotein (LDL) cholesterol (calculated), triglyceride, insulin, glucose, and fibrinogen serum concentrations were measured in 310 women. Baseline information was also collected on medical history, demographic characteristics, and diet.

RESULTS

There were no statistically significant differences in the adjusted mean change from baseline to 3 months between the herbal groups and placebo in total cholesterol, LDL, HDL, triglycerides, glucose, and insulin. Adjusted fibrinogen levels appear to increase in the multibotanical treatment group in comparison with the other herbal groups and placebo overall (P = .02), but there was no statistically significant difference in the pairwise test against placebo (P = .11).

CONCLUSIONS

Black cohosh containing therapies had no demonstrable effects on lipids, glucose, insulin or fibrinogen.

Authors+Show Affiliations

Center for Health Studies, Group Health, Seattle, WA 98101, USA. spangler.l@ghc.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

17275226

Citation

Spangler, Leslie, et al. "The Effects of Black Cohosh Therapies On Lipids, Fibrinogen, Glucose and Insulin." Maturitas, vol. 57, no. 2, 2007, pp. 195-204.
Spangler L, Newton KM, Grothaus LC, et al. The effects of black cohosh therapies on lipids, fibrinogen, glucose and insulin. Maturitas. 2007;57(2):195-204.
Spangler, L., Newton, K. M., Grothaus, L. C., Reed, S. D., Ehrlich, K., & LaCroix, A. Z. (2007). The effects of black cohosh therapies on lipids, fibrinogen, glucose and insulin. Maturitas, 57(2), 195-204.
Spangler L, et al. The Effects of Black Cohosh Therapies On Lipids, Fibrinogen, Glucose and Insulin. Maturitas. 2007 Jun 20;57(2):195-204. PubMed PMID: 17275226.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of black cohosh therapies on lipids, fibrinogen, glucose and insulin. AU - Spangler,Leslie, AU - Newton,Katherine M, AU - Grothaus,Louis C, AU - Reed,Susan D, AU - Ehrlich,Kelly, AU - LaCroix,Andrea Z, Y1 - 2007/02/01/ PY - 2006/09/18/received PY - 2006/12/06/revised PY - 2007/01/02/accepted PY - 2007/2/6/pubmed PY - 2007/7/27/medline PY - 2007/2/6/entrez SP - 195 EP - 204 JF - Maturitas JO - Maturitas VL - 57 IS - 2 N2 - OBJECTIVE: Black cohosh (Actaea racemosa) is an herb commonly used to treat menopausal symptoms. Little is known about its effect on other physiologic parameters that could result in untoward events. This study examines the effect of black cohosh on lipids, fibrinogen, glucose and insulin. METHODS: Three hundred and fifty-one, 45-55 years old, peri or post-menopausal women experiencing vasomotor symptoms participated in a 3-month, double blind trial with randomization to: (1) black cohosh (160 mg daily); (2) multibotanical including black cohosh (200 mg daily); (3) multibotanical plus soy diet counseling; (4) conjugated equine estrogen .625 mg, with or without medroxyprogesterone acetate 2.5mg daily, for women with or without a uterus, respectively; (5) placebo. Baseline and month 3 total cholesterol, high density lipoprotein (HDL) cholesterol, low density lipoprotein (LDL) cholesterol (calculated), triglyceride, insulin, glucose, and fibrinogen serum concentrations were measured in 310 women. Baseline information was also collected on medical history, demographic characteristics, and diet. RESULTS: There were no statistically significant differences in the adjusted mean change from baseline to 3 months between the herbal groups and placebo in total cholesterol, LDL, HDL, triglycerides, glucose, and insulin. Adjusted fibrinogen levels appear to increase in the multibotanical treatment group in comparison with the other herbal groups and placebo overall (P = .02), but there was no statistically significant difference in the pairwise test against placebo (P = .11). CONCLUSIONS: Black cohosh containing therapies had no demonstrable effects on lipids, glucose, insulin or fibrinogen. SN - 0378-5122 UR - https://www.unboundmedicine.com/medline/citation/17275226/The_effects_of_black_cohosh_therapies_on_lipids_fibrinogen_glucose_and_insulin_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-5122(07)00027-8 DB - PRIME DP - Unbound Medicine ER -