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Failure of conjugated linoleic acid supplementation to enhance biosynthesis of docosahexaenoic acid from alpha-linolenic acid in healthy human volunteers.
Prostaglandins Leukot Essent Fatty Acids. 2007 Mar; 76(3):121-30.PL

Abstract

A rate-limiting step in docosahexaenoic acid (DHA) formation from alpha-linolenic acid (ALA) involves peroxisomal oxidation of 24:6n-3 to DHA. The aim of the study was to determine whether conjugated linoleic acid (CLA) would enhance conversion of ALA to DHA in humans on an ALA-supplemented diet. The subjects (n=8 per group) received daily supplementation of ALA (11g) and either CLA (3.2g) or placebo for 8 weeks. At baseline, 4 and 8 weeks, blood was collected for plasma fatty acid analysis and a number of physiological measures were examined. The ALA-supplemented diet increased plasma levels of ALA and eicosapentaenoic acid (EPA). The addition of CLA to the ALA diet resulted in increased plasma levels of CLA, as well as ALA and EPA. Plasma level of DHA was not increased with either the ALA alone or ALA plus CLA supplementation. The results demonstrated that CLA was not effective in enhancing DHA levels in plasma in healthy volunteers.

Authors+Show Affiliations

School of Applied Sciences, RMIT University, Melbourne, Victoria, Australia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17275274

Citation

Attar-Bashi, N M., et al. "Failure of Conjugated Linoleic Acid Supplementation to Enhance Biosynthesis of Docosahexaenoic Acid From Alpha-linolenic Acid in Healthy Human Volunteers." Prostaglandins, Leukotrienes, and Essential Fatty Acids, vol. 76, no. 3, 2007, pp. 121-30.
Attar-Bashi NM, Weisinger RS, Begg DP, et al. Failure of conjugated linoleic acid supplementation to enhance biosynthesis of docosahexaenoic acid from alpha-linolenic acid in healthy human volunteers. Prostaglandins Leukot Essent Fatty Acids. 2007;76(3):121-30.
Attar-Bashi, N. M., Weisinger, R. S., Begg, D. P., Li, D., & Sinclair, A. J. (2007). Failure of conjugated linoleic acid supplementation to enhance biosynthesis of docosahexaenoic acid from alpha-linolenic acid in healthy human volunteers. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 76(3), 121-30.
Attar-Bashi NM, et al. Failure of Conjugated Linoleic Acid Supplementation to Enhance Biosynthesis of Docosahexaenoic Acid From Alpha-linolenic Acid in Healthy Human Volunteers. Prostaglandins Leukot Essent Fatty Acids. 2007;76(3):121-30. PubMed PMID: 17275274.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Failure of conjugated linoleic acid supplementation to enhance biosynthesis of docosahexaenoic acid from alpha-linolenic acid in healthy human volunteers. AU - Attar-Bashi,N M, AU - Weisinger,R S, AU - Begg,D P, AU - Li,D, AU - Sinclair,A J, Y1 - 2007/02/01/ PY - 2006/05/23/received PY - 2006/10/11/revised PY - 2006/11/07/accepted PY - 2007/2/6/pubmed PY - 2007/7/11/medline PY - 2007/2/6/entrez SP - 121 EP - 30 JF - Prostaglandins, leukotrienes, and essential fatty acids JO - Prostaglandins Leukot. Essent. Fatty Acids VL - 76 IS - 3 N2 - A rate-limiting step in docosahexaenoic acid (DHA) formation from alpha-linolenic acid (ALA) involves peroxisomal oxidation of 24:6n-3 to DHA. The aim of the study was to determine whether conjugated linoleic acid (CLA) would enhance conversion of ALA to DHA in humans on an ALA-supplemented diet. The subjects (n=8 per group) received daily supplementation of ALA (11g) and either CLA (3.2g) or placebo for 8 weeks. At baseline, 4 and 8 weeks, blood was collected for plasma fatty acid analysis and a number of physiological measures were examined. The ALA-supplemented diet increased plasma levels of ALA and eicosapentaenoic acid (EPA). The addition of CLA to the ALA diet resulted in increased plasma levels of CLA, as well as ALA and EPA. Plasma level of DHA was not increased with either the ALA alone or ALA plus CLA supplementation. The results demonstrated that CLA was not effective in enhancing DHA levels in plasma in healthy volunteers. SN - 0952-3278 UR - https://www.unboundmedicine.com/medline/citation/17275274/Failure_of_conjugated_linoleic_acid_supplementation_to_enhance_biosynthesis_of_docosahexaenoic_acid_from_alpha_linolenic_acid_in_healthy_human_volunteers_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0952-3278(06)00181-5 DB - PRIME DP - Unbound Medicine ER -