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Effects of D-cycloserine on extinction of learned fear to an olfactory cue.
Neurobiol Learn Mem. 2007 May; 87(4):476-82.NL

Abstract

D-cycloserine (DCS), a partial NMDA receptor agonist, facilitates extinction of learned fear in rats and has been used to treat anxiety disorders in clinical populations. However, research into the effects of DCS on extinction is still in its infancy, with visual cues being the primary fear-eliciting stimuli under investigation. In both human and animal subjects odors have been found to associate strongly with aversive events. Therefore, this study examined the generality of the effects of DCS on extinction by testing odor cues. Sprague-Dawley rats were conditioned and extinguished to an odor using varying parameters, injected with either saline or DCS (15 mg/kg) following extinction, and then tested for a freezing response 24 h later. Experiment 1 demonstrated that after 3 odor-shock pairings, rats did not display short-term extinction and DCS had no effect on long-term extinction. Experiment 2 demonstrated that after 3 odor-noise pairings, rats displayed significant short-term extinction and DCS significantly facilitated long-term extinction. Following 2 odor-shock pairings in Experiment 3, half the rats displayed short-term extinction ("extinguishers") and half did not ("non-extinguishers"). DCS facilitated long-term extinction in the "extinguishers" condition but not in the "non-extinguishers" condition. In Experiment 4, following 2 odor-shock pairings and an extra extinction session, DCS had a significant facilitatory effect on long-term extinction. Thus, extinction of freezing to an odor cue was facilitated by systemic injections of DCS, but only when some amount of within-session extinction occurred prior to injection.

Authors+Show Affiliations

School of Psychology, University of New South Wales, Sydney, Australia.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17275356

Citation

Weber, Marianne, et al. "Effects of D-cycloserine On Extinction of Learned Fear to an Olfactory Cue." Neurobiology of Learning and Memory, vol. 87, no. 4, 2007, pp. 476-82.
Weber M, Hart J, Richardson R. Effects of D-cycloserine on extinction of learned fear to an olfactory cue. Neurobiol Learn Mem. 2007;87(4):476-82.
Weber, M., Hart, J., & Richardson, R. (2007). Effects of D-cycloserine on extinction of learned fear to an olfactory cue. Neurobiology of Learning and Memory, 87(4), 476-82.
Weber M, Hart J, Richardson R. Effects of D-cycloserine On Extinction of Learned Fear to an Olfactory Cue. Neurobiol Learn Mem. 2007;87(4):476-82. PubMed PMID: 17275356.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of D-cycloserine on extinction of learned fear to an olfactory cue. AU - Weber,Marianne, AU - Hart,Joe, AU - Richardson,Rick, Y1 - 2007/02/01/ PY - 2006/07/11/received PY - 2006/11/28/revised PY - 2006/12/21/accepted PY - 2007/2/6/pubmed PY - 2007/7/17/medline PY - 2007/2/6/entrez SP - 476 EP - 82 JF - Neurobiology of learning and memory JO - Neurobiol Learn Mem VL - 87 IS - 4 N2 - D-cycloserine (DCS), a partial NMDA receptor agonist, facilitates extinction of learned fear in rats and has been used to treat anxiety disorders in clinical populations. However, research into the effects of DCS on extinction is still in its infancy, with visual cues being the primary fear-eliciting stimuli under investigation. In both human and animal subjects odors have been found to associate strongly with aversive events. Therefore, this study examined the generality of the effects of DCS on extinction by testing odor cues. Sprague-Dawley rats were conditioned and extinguished to an odor using varying parameters, injected with either saline or DCS (15 mg/kg) following extinction, and then tested for a freezing response 24 h later. Experiment 1 demonstrated that after 3 odor-shock pairings, rats did not display short-term extinction and DCS had no effect on long-term extinction. Experiment 2 demonstrated that after 3 odor-noise pairings, rats displayed significant short-term extinction and DCS significantly facilitated long-term extinction. Following 2 odor-shock pairings in Experiment 3, half the rats displayed short-term extinction ("extinguishers") and half did not ("non-extinguishers"). DCS facilitated long-term extinction in the "extinguishers" condition but not in the "non-extinguishers" condition. In Experiment 4, following 2 odor-shock pairings and an extra extinction session, DCS had a significant facilitatory effect on long-term extinction. Thus, extinction of freezing to an odor cue was facilitated by systemic injections of DCS, but only when some amount of within-session extinction occurred prior to injection. SN - 1074-7427 UR - https://www.unboundmedicine.com/medline/citation/17275356/Effects_of_D_cycloserine_on_extinction_of_learned_fear_to_an_olfactory_cue_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1074-7427(06)00185-7 DB - PRIME DP - Unbound Medicine ER -