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Neuropeptide Y acts at Y1 receptors in the rostral ventral medulla to inhibit neuropathic pain.
Pain. 2007 Sep; 131(1-2):83-95.PAIN

Abstract

Brain microinjection studies in the rat using local anesthetics suggest that the rostral ventral medulla (RVM) contributes to the facilitation of neuropathic pain. However, these studies were restricted to a single model of neuropathic pain (the spinal nerve ligation model) and to just two stimulus modalities (non-noxious tactile stimulus and heat). Also, few neurotransmitter systems have been shown to modulate descending facilitation. After either partial sciatic nerve ligation (PSNL) or spared nerve injury (SNI), we found that unilateral or bilateral microinjection of lidocaine into the RVM reduced not only mechanical allodynia (decreased threshold to von Frey hairs and/or an automated device) and mechanical hyperalgesia (increased paw lifting in response to a noxious pin), but also cold hypersensitivity (increased lifting in response to the hindpaw application of a drop of acetone). Application of a drop of water did not elicit paw withdrawal, indicating that the acetone test is indeed a measure of cold hypersensitivity. We found significant neuropeptide Y Y1-like immunoreactivity within, and lateral to, the midline RVM. Intra-RVM injection of neuropeptide Y (NPY) dose-dependently inhibited the mechanical and cold hypersensitivity associated with PSNL or SNI, an effect that could be blocked by the Y1 receptor antagonist BIBO 3304. We conclude that medullary facilitation spans multiple behavioral signs of allodynia and hyperalgesia in multiple models of neuropathic pain. Furthermore, NPY inhibits behavioral signs of neuropathic pain, possibly by acting at Y1 receptors in the RVM.

Authors+Show Affiliations

Department of Pharmacology, School of Medicine, Tulane University, New Orleans, LA 70112, USA. taylorb@tulane.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

17276005

Citation

Taylor, Bradley K., et al. "Neuropeptide Y Acts at Y1 Receptors in the Rostral Ventral Medulla to Inhibit Neuropathic Pain." Pain, vol. 131, no. 1-2, 2007, pp. 83-95.
Taylor BK, Abhyankar SS, Vo NT, et al. Neuropeptide Y acts at Y1 receptors in the rostral ventral medulla to inhibit neuropathic pain. Pain. 2007;131(1-2):83-95.
Taylor, B. K., Abhyankar, S. S., Vo, N. T., Kriedt, C. L., Churi, S. B., & Urban, J. H. (2007). Neuropeptide Y acts at Y1 receptors in the rostral ventral medulla to inhibit neuropathic pain. Pain, 131(1-2), 83-95.
Taylor BK, et al. Neuropeptide Y Acts at Y1 Receptors in the Rostral Ventral Medulla to Inhibit Neuropathic Pain. Pain. 2007;131(1-2):83-95. PubMed PMID: 17276005.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neuropeptide Y acts at Y1 receptors in the rostral ventral medulla to inhibit neuropathic pain. AU - Taylor,Bradley K, AU - Abhyankar,Sarang S, AU - Vo,Ngoc-Tram T, AU - Kriedt,Christopher L, AU - Churi,Sajay B, AU - Urban,Janice H, Y1 - 2007/02/02/ PY - 2005/08/12/received PY - 2006/11/05/revised PY - 2006/12/19/accepted PY - 2007/2/6/pubmed PY - 2007/9/5/medline PY - 2007/2/6/entrez SP - 83 EP - 95 JF - Pain JO - Pain VL - 131 IS - 1-2 N2 - Brain microinjection studies in the rat using local anesthetics suggest that the rostral ventral medulla (RVM) contributes to the facilitation of neuropathic pain. However, these studies were restricted to a single model of neuropathic pain (the spinal nerve ligation model) and to just two stimulus modalities (non-noxious tactile stimulus and heat). Also, few neurotransmitter systems have been shown to modulate descending facilitation. After either partial sciatic nerve ligation (PSNL) or spared nerve injury (SNI), we found that unilateral or bilateral microinjection of lidocaine into the RVM reduced not only mechanical allodynia (decreased threshold to von Frey hairs and/or an automated device) and mechanical hyperalgesia (increased paw lifting in response to a noxious pin), but also cold hypersensitivity (increased lifting in response to the hindpaw application of a drop of acetone). Application of a drop of water did not elicit paw withdrawal, indicating that the acetone test is indeed a measure of cold hypersensitivity. We found significant neuropeptide Y Y1-like immunoreactivity within, and lateral to, the midline RVM. Intra-RVM injection of neuropeptide Y (NPY) dose-dependently inhibited the mechanical and cold hypersensitivity associated with PSNL or SNI, an effect that could be blocked by the Y1 receptor antagonist BIBO 3304. We conclude that medullary facilitation spans multiple behavioral signs of allodynia and hyperalgesia in multiple models of neuropathic pain. Furthermore, NPY inhibits behavioral signs of neuropathic pain, possibly by acting at Y1 receptors in the RVM. SN - 1872-6623 UR - https://www.unboundmedicine.com/medline/citation/17276005/Neuropeptide_Y_acts_at_Y1_receptors_in_the_rostral_ventral_medulla_to_inhibit_neuropathic_pain_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-3959(06)00703-2 DB - PRIME DP - Unbound Medicine ER -