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Gender-related differences in presentation, treatment, and outcome of patients with atrial fibrillation in Europe: a report from the Euro Heart Survey on Atrial Fibrillation.
J Am Coll Cardiol. 2007 Feb 06; 49(5):572-7.JACC

Abstract

OBJECTIVES

This study sought to investigate gender-related differences in patients with atrial fibrillation (AF) in Europe.

BACKGROUND

Gender-related differences may play a significant role in AF.

METHODS

We analyzed the data of 5,333 patients (42% female) enrolled in the Euro Heart Survey on Atrial Fibrillation.

RESULTS

Compared with men, the women were older, had a lower quality of life (QoL), had more comorbidities, more often had heart failure (HF) with preserved left ventricular systolic function (18% vs. 7%, p < 0.001), and less often had HF with systolic dysfunction (17% vs. 26%, p < 0.001). Among patients with typical AF symptoms (56% of women, 49% of men), there was no gender-related difference in the choice of rate or rhythm control. Among patients with atypical or no symptoms (44% of women, 51% of men), women less frequently underwent rhythm control (39% vs. 51%, p < 0.001) than did men. Women underwent less electrical cardioversion (22% vs. 28%, p < 0.001). Prescription of oral anticoagulants was identical (65%) in both genders. One-year outcome was similar except that women had a higher chance for stroke (odds ratio 1.83 in multivariable regression analysis, p = 0.019).

CONCLUSIONS

Women with AF had more comorbidities, more HF with preserved systolic function, and a lower QoL than men. In the large group with atypical or no symptoms, women were treated appropriately more conservatively with less rhythm control than men. Women had a higher chance for stroke. Long-term QoL changes and other morbidities and mortality were similar.

Authors+Show Affiliations

University of Athens, Second Cardiology Department, Attikon University Hospital, Athens, Greece. nikolaosdagres@yahoo.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

17276181

Citation

Dagres, Nikolaos, et al. "Gender-related Differences in Presentation, Treatment, and Outcome of Patients With Atrial Fibrillation in Europe: a Report From the Euro Heart Survey On Atrial Fibrillation." Journal of the American College of Cardiology, vol. 49, no. 5, 2007, pp. 572-7.
Dagres N, Nieuwlaat R, Vardas PE, et al. Gender-related differences in presentation, treatment, and outcome of patients with atrial fibrillation in Europe: a report from the Euro Heart Survey on Atrial Fibrillation. J Am Coll Cardiol. 2007;49(5):572-7.
Dagres, N., Nieuwlaat, R., Vardas, P. E., Andresen, D., Lévy, S., Cobbe, S., Kremastinos, D. T., Breithardt, G., Cokkinos, D. V., & Crijns, H. J. (2007). Gender-related differences in presentation, treatment, and outcome of patients with atrial fibrillation in Europe: a report from the Euro Heart Survey on Atrial Fibrillation. Journal of the American College of Cardiology, 49(5), 572-7.
Dagres N, et al. Gender-related Differences in Presentation, Treatment, and Outcome of Patients With Atrial Fibrillation in Europe: a Report From the Euro Heart Survey On Atrial Fibrillation. J Am Coll Cardiol. 2007 Feb 6;49(5):572-7. PubMed PMID: 17276181.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gender-related differences in presentation, treatment, and outcome of patients with atrial fibrillation in Europe: a report from the Euro Heart Survey on Atrial Fibrillation. AU - Dagres,Nikolaos, AU - Nieuwlaat,Robby, AU - Vardas,Panos E, AU - Andresen,Dietrich, AU - Lévy,Samuel, AU - Cobbe,Stuart, AU - Kremastinos,Dimitrios Th, AU - Breithardt,Günter, AU - Cokkinos,Dennis V, AU - Crijns,Harry J G M, Y1 - 2007/01/22/ PY - 2006/04/07/received PY - 2006/09/29/revised PY - 2006/10/16/accepted PY - 2007/2/6/pubmed PY - 2007/4/4/medline PY - 2007/2/6/entrez SP - 572 EP - 7 JF - Journal of the American College of Cardiology JO - J Am Coll Cardiol VL - 49 IS - 5 N2 - OBJECTIVES: This study sought to investigate gender-related differences in patients with atrial fibrillation (AF) in Europe. BACKGROUND: Gender-related differences may play a significant role in AF. METHODS: We analyzed the data of 5,333 patients (42% female) enrolled in the Euro Heart Survey on Atrial Fibrillation. RESULTS: Compared with men, the women were older, had a lower quality of life (QoL), had more comorbidities, more often had heart failure (HF) with preserved left ventricular systolic function (18% vs. 7%, p < 0.001), and less often had HF with systolic dysfunction (17% vs. 26%, p < 0.001). Among patients with typical AF symptoms (56% of women, 49% of men), there was no gender-related difference in the choice of rate or rhythm control. Among patients with atypical or no symptoms (44% of women, 51% of men), women less frequently underwent rhythm control (39% vs. 51%, p < 0.001) than did men. Women underwent less electrical cardioversion (22% vs. 28%, p < 0.001). Prescription of oral anticoagulants was identical (65%) in both genders. One-year outcome was similar except that women had a higher chance for stroke (odds ratio 1.83 in multivariable regression analysis, p = 0.019). CONCLUSIONS: Women with AF had more comorbidities, more HF with preserved systolic function, and a lower QoL than men. In the large group with atypical or no symptoms, women were treated appropriately more conservatively with less rhythm control than men. Women had a higher chance for stroke. Long-term QoL changes and other morbidities and mortality were similar. SN - 1558-3597 UR - https://www.unboundmedicine.com/medline/citation/17276181/Gender_related_differences_in_presentation_treatment_and_outcome_of_patients_with_atrial_fibrillation_in_Europe:_a_report_from_the_Euro_Heart_Survey_on_Atrial_Fibrillation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0735-1097(06)02858-0 DB - PRIME DP - Unbound Medicine ER -