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Effect of fluoxetine on circadian rhythm of melatonin in patients with major depressive disorder.
Neuro Endocrinol Lett. 2007 Feb; 28(1):28-32.NE

Abstract

OBJECTIVES

The purpose of this study is to explore the response of melatonin circadian rhythm to fluoxetine treatment and its relationship with clinical therapeutic effect.

METHODS

This study investigated salivary melatonin in 13 outpatients with major depressive disorder and age- and sex-matched healthy controls. Depressed patients received six weeks fluoxetine (20 mg/day) treatment, and saliva was collected before and four weeks after treatment. In sampling days, a total of 12 time-point salivary melatonin was measured over 24-hours. Multioscillator cosinor model was used to fit the rhythms.

RESULTS

There was no difference of circadian melatonin rhythms in depressed patients, and melatonin was not significantly lower after fluoxetine treatment. To our surprise, the melatonin amplitude (Before minus After) was positively correlated with the improvement in Hamilton Depression Rating Scale (HDRS) scores at day 42 whereas there was no such correlation at day 28.

CONCLUSIONS

Melatonin rhythms were similar between depressed patients and matched healthy controls. The interesting finding that the difference of salivary melatonin amplitude was correlated with the clinical improvement after six weeks fluoxetine treatment deserve further study.

Authors+Show Affiliations

Hefei National Laboratory for Physical Sciences at Microscale and Department of Neurobiology, School of Life Science, University of Science and Technology of China, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17277729

Citation

Tan, Zhong-Lin, et al. "Effect of Fluoxetine On Circadian Rhythm of Melatonin in Patients With Major Depressive Disorder." Neuro Endocrinology Letters, vol. 28, no. 1, 2007, pp. 28-32.
Tan ZL, Bao AM, Zhao GQ, et al. Effect of fluoxetine on circadian rhythm of melatonin in patients with major depressive disorder. Neuro Endocrinol Lett. 2007;28(1):28-32.
Tan, Z. L., Bao, A. M., Zhao, G. Q., Liu, Y. J., & Zhou, J. N. (2007). Effect of fluoxetine on circadian rhythm of melatonin in patients with major depressive disorder. Neuro Endocrinology Letters, 28(1), 28-32.
Tan ZL, et al. Effect of Fluoxetine On Circadian Rhythm of Melatonin in Patients With Major Depressive Disorder. Neuro Endocrinol Lett. 2007;28(1):28-32. PubMed PMID: 17277729.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of fluoxetine on circadian rhythm of melatonin in patients with major depressive disorder. AU - Tan,Zhong-Lin, AU - Bao,Ai-Min, AU - Zhao,Guo-Qiu, AU - Liu,Ya-Jing, AU - Zhou,Jiang-Ning, PY - 2006/12/06/received PY - 2007/01/07/accepted PY - 2007/2/6/pubmed PY - 2007/5/9/medline PY - 2007/2/6/entrez SP - 28 EP - 32 JF - Neuro endocrinology letters JO - Neuro Endocrinol Lett VL - 28 IS - 1 N2 - OBJECTIVES: The purpose of this study is to explore the response of melatonin circadian rhythm to fluoxetine treatment and its relationship with clinical therapeutic effect. METHODS: This study investigated salivary melatonin in 13 outpatients with major depressive disorder and age- and sex-matched healthy controls. Depressed patients received six weeks fluoxetine (20 mg/day) treatment, and saliva was collected before and four weeks after treatment. In sampling days, a total of 12 time-point salivary melatonin was measured over 24-hours. Multioscillator cosinor model was used to fit the rhythms. RESULTS: There was no difference of circadian melatonin rhythms in depressed patients, and melatonin was not significantly lower after fluoxetine treatment. To our surprise, the melatonin amplitude (Before minus After) was positively correlated with the improvement in Hamilton Depression Rating Scale (HDRS) scores at day 42 whereas there was no such correlation at day 28. CONCLUSIONS: Melatonin rhythms were similar between depressed patients and matched healthy controls. The interesting finding that the difference of salivary melatonin amplitude was correlated with the clinical improvement after six weeks fluoxetine treatment deserve further study. SN - 0172-780X UR - https://www.unboundmedicine.com/medline/citation/17277729/Effect_of_fluoxetine_on_circadian_rhythm_of_melatonin_in_patients_with_major_depressive_disorder_ DB - PRIME DP - Unbound Medicine ER -