Tags

Type your tag names separated by a space and hit enter

Cryotherapy in the prevention of oral mucositis in patients receiving low-dose methotrexate following myeloablative allogeneic stem cell transplantation: a prospective randomized study of the Gruppo Italiano Trapianto di Midollo Osseo nurses group.
Bone Marrow Transplant. 2007 Mar; 39(6):347-52.BM

Abstract

Severe oral mucositis is a major cause of morbidity following allogeneic hematopoietic stem cell transplantation (AHSCT). Cryotherapy, that is, the application of ice chips on the mucosa of the oral cavity during the administration of antineoplastic agents, may reduce the incidence and severity of chemotherapy-related oral mucositis. In this multicenter randomized study, we addressed whether cryotherapy during MTX administration is effective in the prevention of severe oral mucositis in patients undergoing myeloablative AHSCT. One hundred and thirty patients undergoing myeloablative AHSCT and MTX-containing GVHD prophylaxis were enrolled and randomized to receive or not receive cryotherapy during MTX administration. The incidence of severe (grade 3-4) oral mucositis, the primary end point of the study, was comparable in patients receiving or not cryotherapy. Moreover, no difference was observed in the incidence of oral mucositis grade 2-4 and the duration of oral mucositis grade 3-4 or 2-4, or in the kinetics of mucositis over time. In univariate and multivariate analysis, severe oral mucositis correlated with TBI in the conditioning regimen and lack of folinic acid rescue following MTX administration. Thus, cryotherapy during MTX administration does not reduce severe oral mucositis in patients undergoing myeloablative allogeneic HSCT. Future studies will assess cryotherapy before allogeneic HSCT.

Authors+Show Affiliations

Department of Hematology and Medical Oncology Seragnoli, University of Bologna, Bologna, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17277790

Citation

Gori, E, et al. "Cryotherapy in the Prevention of Oral Mucositis in Patients Receiving Low-dose Methotrexate Following Myeloablative Allogeneic Stem Cell Transplantation: a Prospective Randomized Study of the Gruppo Italiano Trapianto Di Midollo Osseo Nurses Group." Bone Marrow Transplantation, vol. 39, no. 6, 2007, pp. 347-52.
Gori E, Arpinati M, Bonifazi F, et al. Cryotherapy in the prevention of oral mucositis in patients receiving low-dose methotrexate following myeloablative allogeneic stem cell transplantation: a prospective randomized study of the Gruppo Italiano Trapianto di Midollo Osseo nurses group. Bone Marrow Transplant. 2007;39(6):347-52.
Gori, E., Arpinati, M., Bonifazi, F., Errico, A., Mega, A., Alberani, F., Sabbi, V., Costazza, G., Leanza, S., Borrelli, C., Berni, M., Feraut, C., Polato, E., Altieri, M. C., Pirola, E., Loddo, M. C., Banfi, M., Barzetti, L., Calza, S., ... Baccarani, M. (2007). Cryotherapy in the prevention of oral mucositis in patients receiving low-dose methotrexate following myeloablative allogeneic stem cell transplantation: a prospective randomized study of the Gruppo Italiano Trapianto di Midollo Osseo nurses group. Bone Marrow Transplantation, 39(6), 347-52.
Gori E, et al. Cryotherapy in the Prevention of Oral Mucositis in Patients Receiving Low-dose Methotrexate Following Myeloablative Allogeneic Stem Cell Transplantation: a Prospective Randomized Study of the Gruppo Italiano Trapianto Di Midollo Osseo Nurses Group. Bone Marrow Transplant. 2007;39(6):347-52. PubMed PMID: 17277790.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cryotherapy in the prevention of oral mucositis in patients receiving low-dose methotrexate following myeloablative allogeneic stem cell transplantation: a prospective randomized study of the Gruppo Italiano Trapianto di Midollo Osseo nurses group. AU - Gori,E, AU - Arpinati,M, AU - Bonifazi,F, AU - Errico,A, AU - Mega,A, AU - Alberani,F, AU - Sabbi,V, AU - Costazza,G, AU - Leanza,S, AU - Borrelli,C, AU - Berni,M, AU - Feraut,C, AU - Polato,E, AU - Altieri,M C, AU - Pirola,E, AU - Loddo,M C, AU - Banfi,M, AU - Barzetti,L, AU - Calza,S, AU - Brignoli,C, AU - Bandini,G, AU - De Vivo,A, AU - Bosi,A, AU - Baccarani,M, Y1 - 2007/02/05/ PY - 2007/2/6/pubmed PY - 2007/4/14/medline PY - 2007/2/6/entrez SP - 347 EP - 52 JF - Bone marrow transplantation JO - Bone Marrow Transplant. VL - 39 IS - 6 N2 - Severe oral mucositis is a major cause of morbidity following allogeneic hematopoietic stem cell transplantation (AHSCT). Cryotherapy, that is, the application of ice chips on the mucosa of the oral cavity during the administration of antineoplastic agents, may reduce the incidence and severity of chemotherapy-related oral mucositis. In this multicenter randomized study, we addressed whether cryotherapy during MTX administration is effective in the prevention of severe oral mucositis in patients undergoing myeloablative AHSCT. One hundred and thirty patients undergoing myeloablative AHSCT and MTX-containing GVHD prophylaxis were enrolled and randomized to receive or not receive cryotherapy during MTX administration. The incidence of severe (grade 3-4) oral mucositis, the primary end point of the study, was comparable in patients receiving or not cryotherapy. Moreover, no difference was observed in the incidence of oral mucositis grade 2-4 and the duration of oral mucositis grade 3-4 or 2-4, or in the kinetics of mucositis over time. In univariate and multivariate analysis, severe oral mucositis correlated with TBI in the conditioning regimen and lack of folinic acid rescue following MTX administration. Thus, cryotherapy during MTX administration does not reduce severe oral mucositis in patients undergoing myeloablative allogeneic HSCT. Future studies will assess cryotherapy before allogeneic HSCT. SN - 0268-3369 UR - https://www.unboundmedicine.com/medline/citation/17277790/Cryotherapy_in_the_prevention_of_oral_mucositis_in_patients_receiving_low_dose_methotrexate_following_myeloablative_allogeneic_stem_cell_transplantation:_a_prospective_randomized_study_of_the_Gruppo_Italiano_Trapianto_di_Midollo_Osseo_nurses_group_ L2 - http://dx.doi.org/10.1038/sj.bmt.1705590 DB - PRIME DP - Unbound Medicine ER -