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Diagnosis of coccidioidomycosis by antigen detection using cross-reaction with a Histoplasma antigen.
Clin Infect Dis. 2007 Mar 01; 44(5):e50-4.CI

Abstract

BACKGROUND

In 2005, patients with coccidioidomycosis were observed to have positive Histoplasma antigen test results.

METHODS

We performed a review of the records of patients with coccidioidomycosis who were under our care who underwent testing for Histoplasma antigen to determine the value of this test in the diagnosis of coccidioidomycosis. Many of the patients were immunosuppressed and critically ill.

RESULTS

The Histoplasma antigen test had positive results when urine samples from 11 (58%) of 19 patients who had acute or chronic coccidioidomycosis were tested. The sensitivity was highest for patients who had acute coccidioidomycosis, and antigenuria was detected in 11 (79%) of 14 patients. One patient who had chronic coccidioidomycosis but who had a negative result when a urine sample was tested had antigen detected in bronchoalveolar lavage fluid.

CONCLUSIONS

Physicians should be alerted that infections with Coccidioides species may cause positive Histoplasma antigen test results. There is potential for the use of this test in the diagnosis of coccidioidomycosis by taking advantage of this observed cross-reactivity. The greatest benefit appears to be in the population of seriously ill patients with acute pneumonia who live in areas that are endemic for Coccidioides infection.

Authors+Show Affiliations

Body Positive, Phoenix, Arizona, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

17278049

Citation

Kuberski, Tim, et al. "Diagnosis of Coccidioidomycosis By Antigen Detection Using Cross-reaction With a Histoplasma Antigen." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, vol. 44, no. 5, 2007, pp. e50-4.
Kuberski T, Myers R, Wheat LJ, et al. Diagnosis of coccidioidomycosis by antigen detection using cross-reaction with a Histoplasma antigen. Clin Infect Dis. 2007;44(5):e50-4.
Kuberski, T., Myers, R., Wheat, L. J., Durkin, M., Connolly, P., Kubak, B. M., Bruckner, D., & Pegues, D. (2007). Diagnosis of coccidioidomycosis by antigen detection using cross-reaction with a Histoplasma antigen. Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, 44(5), e50-4.
Kuberski T, et al. Diagnosis of Coccidioidomycosis By Antigen Detection Using Cross-reaction With a Histoplasma Antigen. Clin Infect Dis. 2007 Mar 1;44(5):e50-4. PubMed PMID: 17278049.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diagnosis of coccidioidomycosis by antigen detection using cross-reaction with a Histoplasma antigen. AU - Kuberski,Tim, AU - Myers,Robert, AU - Wheat,L Joseph, AU - Durkin,Michelle, AU - Connolly,Patricia, AU - Kubak,Bernard M, AU - Bruckner,David, AU - Pegues,David, Y1 - 2007/01/25/ PY - 2006/09/20/received PY - 2006/11/06/accepted PY - 2007/2/6/pubmed PY - 2007/3/27/medline PY - 2007/2/6/entrez SP - e50 EP - 4 JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America JO - Clin Infect Dis VL - 44 IS - 5 N2 - BACKGROUND: In 2005, patients with coccidioidomycosis were observed to have positive Histoplasma antigen test results. METHODS: We performed a review of the records of patients with coccidioidomycosis who were under our care who underwent testing for Histoplasma antigen to determine the value of this test in the diagnosis of coccidioidomycosis. Many of the patients were immunosuppressed and critically ill. RESULTS: The Histoplasma antigen test had positive results when urine samples from 11 (58%) of 19 patients who had acute or chronic coccidioidomycosis were tested. The sensitivity was highest for patients who had acute coccidioidomycosis, and antigenuria was detected in 11 (79%) of 14 patients. One patient who had chronic coccidioidomycosis but who had a negative result when a urine sample was tested had antigen detected in bronchoalveolar lavage fluid. CONCLUSIONS: Physicians should be alerted that infections with Coccidioides species may cause positive Histoplasma antigen test results. There is potential for the use of this test in the diagnosis of coccidioidomycosis by taking advantage of this observed cross-reactivity. The greatest benefit appears to be in the population of seriously ill patients with acute pneumonia who live in areas that are endemic for Coccidioides infection. SN - 1537-6591 UR - https://www.unboundmedicine.com/medline/citation/17278049/Diagnosis_of_coccidioidomycosis_by_antigen_detection_using_cross_reaction_with_a_Histoplasma_antigen_ L2 - https://academic.oup.com/cid/article-lookup/doi/10.1086/511684 DB - PRIME DP - Unbound Medicine ER -