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Cannabis and psychosis: an update on course and biological plausible mechanisms.
Curr Opin Psychiatry. 2007 Mar; 20(2):116-20.CO

Abstract

PURPOSE OF REVIEW

Cannabis use is the most commonly abused illicit substance. Its relation with psychosis remains a topic of debate. Epidemiological studies suggest that cannabis is a component cause accounting for approximately 10% of cases. An increasing number of studies have been published on neurobiological effects of cannabis and vulnerability of psychosis.

RECENT FINDINGS

Acute cannabis administration can induce memory impairments, sometimes persisting months following abstinence. There is no evidence that residual effects on cognition remain after years of abstinence. The scarce literature on neuro-imaging mainly done in nonpsychotic populations, show little evidence that cannabis has effects on brain anatomy. Acute effects of cannabis include increases of cerebral blood flow, whereas long-term effects of cannabis include attenuation of cerebral blood flow. In animals Delta9-tetrahydrocannabinol enhances dopaminergic neurotransmission in brain regions known to be implicated in psychosis. Studies in humans show that genetic vulnerability may add to increased risk of developing psychosis and cognitive impairments following cannabis consumption. Delta9-tetrahydrocannabinol induces psychotic like states and memory impairments in healthy volunteers.

SUMMARY

Simultaneously with increasing understanding of neurobiological cannabis effects, there is a lack of studies in people with psychosis. There are plausible mechanisms that might explain the psychotogenic effects of cannabis.

Authors+Show Affiliations

Department of Psychiatry, Academic Medical Centre University of Amsterdam, The Netherlands. d.h.linszen@amc.uva.nlNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

17278907

Citation

Linszen, Don, and Therese van Amelsvoort. "Cannabis and Psychosis: an Update On Course and Biological Plausible Mechanisms." Current Opinion in Psychiatry, vol. 20, no. 2, 2007, pp. 116-20.
Linszen D, van Amelsvoort T. Cannabis and psychosis: an update on course and biological plausible mechanisms. Curr Opin Psychiatry. 2007;20(2):116-20.
Linszen, D., & van Amelsvoort, T. (2007). Cannabis and psychosis: an update on course and biological plausible mechanisms. Current Opinion in Psychiatry, 20(2), 116-20.
Linszen D, van Amelsvoort T. Cannabis and Psychosis: an Update On Course and Biological Plausible Mechanisms. Curr Opin Psychiatry. 2007;20(2):116-20. PubMed PMID: 17278907.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cannabis and psychosis: an update on course and biological plausible mechanisms. AU - Linszen,Don, AU - van Amelsvoort,Therese, PY - 2007/2/7/pubmed PY - 2007/5/3/medline PY - 2007/2/7/entrez SP - 116 EP - 20 JF - Current opinion in psychiatry JO - Curr Opin Psychiatry VL - 20 IS - 2 N2 - PURPOSE OF REVIEW: Cannabis use is the most commonly abused illicit substance. Its relation with psychosis remains a topic of debate. Epidemiological studies suggest that cannabis is a component cause accounting for approximately 10% of cases. An increasing number of studies have been published on neurobiological effects of cannabis and vulnerability of psychosis. RECENT FINDINGS: Acute cannabis administration can induce memory impairments, sometimes persisting months following abstinence. There is no evidence that residual effects on cognition remain after years of abstinence. The scarce literature on neuro-imaging mainly done in nonpsychotic populations, show little evidence that cannabis has effects on brain anatomy. Acute effects of cannabis include increases of cerebral blood flow, whereas long-term effects of cannabis include attenuation of cerebral blood flow. In animals Delta9-tetrahydrocannabinol enhances dopaminergic neurotransmission in brain regions known to be implicated in psychosis. Studies in humans show that genetic vulnerability may add to increased risk of developing psychosis and cognitive impairments following cannabis consumption. Delta9-tetrahydrocannabinol induces psychotic like states and memory impairments in healthy volunteers. SUMMARY: Simultaneously with increasing understanding of neurobiological cannabis effects, there is a lack of studies in people with psychosis. There are plausible mechanisms that might explain the psychotogenic effects of cannabis. SN - 0951-7367 UR - https://www.unboundmedicine.com/medline/citation/17278907/Cannabis_and_psychosis:_an_update_on_course_and_biological_plausible_mechanisms_ DB - PRIME DP - Unbound Medicine ER -