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Approach to managing patients with sulfa allergy: use of antibiotic and nonantibiotic sulfonamides.
Can Fam Physician 2006; 52(11):1434-8CF

Abstract

OBJECTIVE

To present an approach to use of sulfonamide-based (sulfa) medications for patients with sulfa allergy and to explore whether sulfa medications are contraindicated for patients who require them but are allergic to them.

SOURCES OF INFORMATION

A search of current pharmacology textbooks and of MEDLINE from 1966 to the present using the MeSH key words "sulfonamide" and "drug sensitivity" revealed review articles, case reports, one observational study (level II evidence), and reports of consensus opinion (level III evidence).

MAIN MESSAGE

Cross-reactivity between sulfa antibiotics and nonantibiotics is rare, but on occasion it can affect the pharmacologic and clinical management of patients with sulfa allergy.

CONCLUSION

How a physician approaches using sulfa medications for patients with sulfa allergy depends on the certainty and severity of the initial allergy, on whether alternatives are available, and on whether the contemplated agent belongs to the same category of sulfa medications (ie, antibiotic or nonantibiotic) as the initial offending agent.

Authors+Show Affiliations

Civic Campus site, Department of Family Medicine, University of Ottawa, Ontario, Canada. dponka@ottawahospital.on.ca

Pub Type(s)

Case Reports
Journal Article
Review

Language

eng

PubMed ID

17279201

Citation

Ponka, David. "Approach to Managing Patients With Sulfa Allergy: Use of Antibiotic and Nonantibiotic Sulfonamides." Canadian Family Physician Medecin De Famille Canadien, vol. 52, no. 11, 2006, pp. 1434-8.
Ponka D. Approach to managing patients with sulfa allergy: use of antibiotic and nonantibiotic sulfonamides. Can Fam Physician. 2006;52(11):1434-8.
Ponka, D. (2006). Approach to managing patients with sulfa allergy: use of antibiotic and nonantibiotic sulfonamides. Canadian Family Physician Medecin De Famille Canadien, 52(11), pp. 1434-8.
Ponka D. Approach to Managing Patients With Sulfa Allergy: Use of Antibiotic and Nonantibiotic Sulfonamides. Can Fam Physician. 2006;52(11):1434-8. PubMed PMID: 17279201.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Approach to managing patients with sulfa allergy: use of antibiotic and nonantibiotic sulfonamides. A1 - Ponka,David, PY - 2007/2/7/pubmed PY - 2007/4/4/medline PY - 2007/2/7/entrez SP - 1434 EP - 8 JF - Canadian family physician Medecin de famille canadien JO - Can Fam Physician VL - 52 IS - 11 N2 - OBJECTIVE: To present an approach to use of sulfonamide-based (sulfa) medications for patients with sulfa allergy and to explore whether sulfa medications are contraindicated for patients who require them but are allergic to them. SOURCES OF INFORMATION: A search of current pharmacology textbooks and of MEDLINE from 1966 to the present using the MeSH key words "sulfonamide" and "drug sensitivity" revealed review articles, case reports, one observational study (level II evidence), and reports of consensus opinion (level III evidence). MAIN MESSAGE: Cross-reactivity between sulfa antibiotics and nonantibiotics is rare, but on occasion it can affect the pharmacologic and clinical management of patients with sulfa allergy. CONCLUSION: How a physician approaches using sulfa medications for patients with sulfa allergy depends on the certainty and severity of the initial allergy, on whether alternatives are available, and on whether the contemplated agent belongs to the same category of sulfa medications (ie, antibiotic or nonantibiotic) as the initial offending agent. SN - 1715-5258 UR - https://www.unboundmedicine.com/medline/citation/17279201/Approach_to_managing_patients_with_sulfa_allergy:_use_of_antibiotic_and_nonantibiotic_sulfonamides_ L2 - http://www.cfp.ca/cgi/pmidlookup?view=long&pmid=17279201 DB - PRIME DP - Unbound Medicine ER -