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Interaction between oestrogen and oxytocin on hypothalamic-pituitary-adrenal axis activity.
J Neuroendocrinol 2007; 19(3):189-97JN

Abstract

In addition to its role in reproduction, oxytocin has central actions modulating behavioural and hypothalamic-pituitary-adrenal (HPA) axis responses during late pregnancy and lactation. The hypothesis that ovarian hormones modulate the effects of oxytocin on HPA axis activity was studied in 7-day ovariectomised rats receiving oestradiol with or without progesterone replacement and intracerebroventricular (i.c.v) minipump infusion of oxytocin (100 ng/h). In an initial experiment, i.c.v. oxytocin had no effect on basal or restraint-stimulated plasma adrenocorticotrophic hormone (ACTH) and corticosterone concentrations or hypothalamic corticotrophin-releasing factor (CRF) mRNA expression with low oestradiol replacement alone but it had a stimulatory effect in the presence of low oestradiol and progesterone. To investigate further whether oestradiol modulates central actions of oxytocin, rats received low dioestrous (low), pro-oestrous (medium) or pregnancy (high) oestradiol replacement levels, yielding plasma concentrations of < 5, 17.3 +/- 4.5 and 258 +/- 32 pg/ml, respectively, with or without i.c.v. oxytocin. Oestradiol caused dose-dependent increases in basal plasma ACTH and corticosterone concentrations but decreased the ACTH response to restraint stress. In parallel to the changes in basal plasma ACTH, high oestrogen increased basal CRF hnRNA, CRF mRNA in the paraventricular nucleus and pro-opiomelanocortin (POMC) mRNA in the pituitary gland, while decreasing restraint stress-stimulated levels. Intracerebroventricular administration of oxytocin reduced basal and stress-stimulated plasma ACTH, hypothalamic CRF hnRNA (30 min), CRF mRNA and pituitary POMC mRNA (4 h) levels parallel to the increases induced by elevating plasma oestradiol. The present study demonstrates the converse effects of oestradiol on basal and restraint stress-stimulated basal HPA axis activity, and that the ability of central oxytocin to inhibit HPA axis activity depends on the levels of circulating oestradiol.

Authors+Show Affiliations

Section on Endocrine Physiology, Developmental Endocrinology Branch, National Institutes of Child Health and Human Development, NIH, Bethesda, MD 20892, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17280592

Citation

Ochedalski, T, et al. "Interaction Between Oestrogen and Oxytocin On Hypothalamic-pituitary-adrenal Axis Activity." Journal of Neuroendocrinology, vol. 19, no. 3, 2007, pp. 189-97.
Ochedalski T, Subburaju S, Wynn PC, et al. Interaction between oestrogen and oxytocin on hypothalamic-pituitary-adrenal axis activity. J Neuroendocrinol. 2007;19(3):189-97.
Ochedalski, T., Subburaju, S., Wynn, P. C., & Aguilera, G. (2007). Interaction between oestrogen and oxytocin on hypothalamic-pituitary-adrenal axis activity. Journal of Neuroendocrinology, 19(3), pp. 189-97.
Ochedalski T, et al. Interaction Between Oestrogen and Oxytocin On Hypothalamic-pituitary-adrenal Axis Activity. J Neuroendocrinol. 2007;19(3):189-97. PubMed PMID: 17280592.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Interaction between oestrogen and oxytocin on hypothalamic-pituitary-adrenal axis activity. AU - Ochedalski,T, AU - Subburaju,S, AU - Wynn,P C, AU - Aguilera,G, PY - 2007/2/7/pubmed PY - 2007/3/30/medline PY - 2007/2/7/entrez SP - 189 EP - 97 JF - Journal of neuroendocrinology JO - J. Neuroendocrinol. VL - 19 IS - 3 N2 - In addition to its role in reproduction, oxytocin has central actions modulating behavioural and hypothalamic-pituitary-adrenal (HPA) axis responses during late pregnancy and lactation. The hypothesis that ovarian hormones modulate the effects of oxytocin on HPA axis activity was studied in 7-day ovariectomised rats receiving oestradiol with or without progesterone replacement and intracerebroventricular (i.c.v) minipump infusion of oxytocin (100 ng/h). In an initial experiment, i.c.v. oxytocin had no effect on basal or restraint-stimulated plasma adrenocorticotrophic hormone (ACTH) and corticosterone concentrations or hypothalamic corticotrophin-releasing factor (CRF) mRNA expression with low oestradiol replacement alone but it had a stimulatory effect in the presence of low oestradiol and progesterone. To investigate further whether oestradiol modulates central actions of oxytocin, rats received low dioestrous (low), pro-oestrous (medium) or pregnancy (high) oestradiol replacement levels, yielding plasma concentrations of < 5, 17.3 +/- 4.5 and 258 +/- 32 pg/ml, respectively, with or without i.c.v. oxytocin. Oestradiol caused dose-dependent increases in basal plasma ACTH and corticosterone concentrations but decreased the ACTH response to restraint stress. In parallel to the changes in basal plasma ACTH, high oestrogen increased basal CRF hnRNA, CRF mRNA in the paraventricular nucleus and pro-opiomelanocortin (POMC) mRNA in the pituitary gland, while decreasing restraint stress-stimulated levels. Intracerebroventricular administration of oxytocin reduced basal and stress-stimulated plasma ACTH, hypothalamic CRF hnRNA (30 min), CRF mRNA and pituitary POMC mRNA (4 h) levels parallel to the increases induced by elevating plasma oestradiol. The present study demonstrates the converse effects of oestradiol on basal and restraint stress-stimulated basal HPA axis activity, and that the ability of central oxytocin to inhibit HPA axis activity depends on the levels of circulating oestradiol. SN - 0953-8194 UR - https://www.unboundmedicine.com/medline/citation/17280592/Interaction_between_oestrogen_and_oxytocin_on_hypothalamic_pituitary_adrenal_axis_activity_ L2 - https://doi.org/10.1111/j.1365-2826.2006.01525.x DB - PRIME DP - Unbound Medicine ER -