Tags

Type your tag names separated by a space and hit enter

Safety and effectiveness of prophylactic gastrostomy tubes for head and neck cancer patients undergoing chemoradiation.
Surg Oncol. 2006 Dec; 15(4):199-203.SO

Abstract

BACKGROUND

We would like to assess the safety and effectiveness of prophylactic percutaneous endoscopic gastrostomy (PEG) tube feedings during concurrent chemoradiation for head and neck cancer.

METHODS

Patients who underwent chemotherapy and radiation for head and neck malignancies were evaluated for their ability to resume oral feeding following treatment. All patients underwent PEG tube placement prior to the treatment because of the expected mucositis. Gastrostomy tubes were removed following treatment when the patients were able to resume oral feedings without aspiration.

RESULTS

Between March 1999 and 2006, 104 patients with locally advanced head and neck cancer underwent concurrent chemotherapy and radiation. One patient declined placement of gastrostomy tube. Ninety patients (86%) developed grade 3-4 mucositis during chemoradiation. Five patients died during treatment from aspiration pneumonia and sepsis. One hundred two patients lost weight during treatment. The mean and median weight loss during concurrent therapy was, respectively, 8.5 and 8 kg (1-23.5 kg). Following treatment, tube feedings were continued 1-41 months (mean: 8 months; median: 5 months) because of continued weight loss, chronic dysphagia, or aspiration. At a median follow-up of 19 months (1-62 months), no patient developed serious complications from tube feedings.

CONCLUSION

Dysphagia resulting from the severe mucositis produced severe weight loss, despite tube feedings. Gastrostomy tube feedings are safe. Gastrostomy tubes should be placed prophylactically for patients undergoing chemoradiation for head and neck cancer.

Authors+Show Affiliations

Department of Radiation Oncology, University of Arizona, 101 N Campbell Avenue, P.O Box 45081 Tucson, AZ 85724-508, USA. NamPhong.Nguyen@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17280829

Citation

Nguyen, Nam P., et al. "Safety and Effectiveness of Prophylactic Gastrostomy Tubes for Head and Neck Cancer Patients Undergoing Chemoradiation." Surgical Oncology, vol. 15, no. 4, 2006, pp. 199-203.
Nguyen NP, North D, Smith HJ, et al. Safety and effectiveness of prophylactic gastrostomy tubes for head and neck cancer patients undergoing chemoradiation. Surg Oncol. 2006;15(4):199-203.
Nguyen, N. P., North, D., Smith, H. J., Dutta, S., Alfieri, A., Karlsson, U., Lee, H., Martinez, T., Lemanski, C., Nguyen, L. M., Ludin, A., & Sallah, S. (2006). Safety and effectiveness of prophylactic gastrostomy tubes for head and neck cancer patients undergoing chemoradiation. Surgical Oncology, 15(4), 199-203.
Nguyen NP, et al. Safety and Effectiveness of Prophylactic Gastrostomy Tubes for Head and Neck Cancer Patients Undergoing Chemoradiation. Surg Oncol. 2006;15(4):199-203. PubMed PMID: 17280829.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Safety and effectiveness of prophylactic gastrostomy tubes for head and neck cancer patients undergoing chemoradiation. AU - Nguyen,Nam P, AU - North,Debra, AU - Smith,Herbert J, AU - Dutta,Suresh, AU - Alfieri,Alan, AU - Karlsson,Ulf, AU - Lee,Howard, AU - Martinez,Tomas, AU - Lemanski,Claire, AU - Nguyen,Ly M, AU - Ludin,Adir, AU - Sallah,Sabah, Y1 - 2007/02/05/ PY - 2006/09/06/received PY - 2006/11/02/revised PY - 2006/12/12/accepted PY - 2007/2/7/pubmed PY - 2007/10/13/medline PY - 2007/2/7/entrez SP - 199 EP - 203 JF - Surgical oncology JO - Surg Oncol VL - 15 IS - 4 N2 - BACKGROUND: We would like to assess the safety and effectiveness of prophylactic percutaneous endoscopic gastrostomy (PEG) tube feedings during concurrent chemoradiation for head and neck cancer. METHODS: Patients who underwent chemotherapy and radiation for head and neck malignancies were evaluated for their ability to resume oral feeding following treatment. All patients underwent PEG tube placement prior to the treatment because of the expected mucositis. Gastrostomy tubes were removed following treatment when the patients were able to resume oral feedings without aspiration. RESULTS: Between March 1999 and 2006, 104 patients with locally advanced head and neck cancer underwent concurrent chemotherapy and radiation. One patient declined placement of gastrostomy tube. Ninety patients (86%) developed grade 3-4 mucositis during chemoradiation. Five patients died during treatment from aspiration pneumonia and sepsis. One hundred two patients lost weight during treatment. The mean and median weight loss during concurrent therapy was, respectively, 8.5 and 8 kg (1-23.5 kg). Following treatment, tube feedings were continued 1-41 months (mean: 8 months; median: 5 months) because of continued weight loss, chronic dysphagia, or aspiration. At a median follow-up of 19 months (1-62 months), no patient developed serious complications from tube feedings. CONCLUSION: Dysphagia resulting from the severe mucositis produced severe weight loss, despite tube feedings. Gastrostomy tube feedings are safe. Gastrostomy tubes should be placed prophylactically for patients undergoing chemoradiation for head and neck cancer. SN - 0960-7404 UR - https://www.unboundmedicine.com/medline/citation/17280829/Safety_and_effectiveness_of_prophylactic_gastrostomy_tubes_for_head_and_neck_cancer_patients_undergoing_chemoradiation_ DB - PRIME DP - Unbound Medicine ER -