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Evolutionary paradigm of chloroquine-resistant malaria in India.
Trends Parasitol. 2007 Apr; 23(4):132-5.TP

Abstract

Drug pressure in the field is believed to be responsible for the emergence of drug-resistant Plasmodium falciparum, the parasite that causes malaria. Variants of the P. falciparum chloroquine resistance transporter (pfcrt) gene have been shown to be responsible for conferring resistance to the commonly used drug chloroquine. In particular, an amino acid mutation, K76T, was shown to have a strong positive correlation with the chloroquine-resistant varieties of malaria parasites. Global studies have reported highly reduced genetic diversity surrounding K76T in the pfcrt gene, which indicates that the mutation has been a target of positive Darwinian natural selection. However, two recent studies of P. falciparum in India found high genetic diversity in the pfcrt gene, which, at first sight, do not support the role of natural selection in the evolution of chloroquine resistance in India.

Authors+Show Affiliations

Evolutionary Genomics and Bioinformatics Laboratory, National Institute of Malaria Research, 22 Sham Nath Marg, Delhi 110054, India. aparup@mrcindia.orgNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17280870

Citation

Das, Aparup, and Aditya Prasad Dash. "Evolutionary Paradigm of Chloroquine-resistant Malaria in India." Trends in Parasitology, vol. 23, no. 4, 2007, pp. 132-5.
Das A, Dash AP. Evolutionary paradigm of chloroquine-resistant malaria in India. Trends Parasitol. 2007;23(4):132-5.
Das, A., & Dash, A. P. (2007). Evolutionary paradigm of chloroquine-resistant malaria in India. Trends in Parasitology, 23(4), 132-5.
Das A, Dash AP. Evolutionary Paradigm of Chloroquine-resistant Malaria in India. Trends Parasitol. 2007;23(4):132-5. PubMed PMID: 17280870.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evolutionary paradigm of chloroquine-resistant malaria in India. AU - Das,Aparup, AU - Dash,Aditya Prasad, Y1 - 2007/02/05/ PY - 2006/10/08/received PY - 2006/12/18/revised PY - 2007/01/26/accepted PY - 2007/2/7/pubmed PY - 2007/6/8/medline PY - 2007/2/7/entrez SP - 132 EP - 5 JF - Trends in parasitology JO - Trends Parasitol VL - 23 IS - 4 N2 - Drug pressure in the field is believed to be responsible for the emergence of drug-resistant Plasmodium falciparum, the parasite that causes malaria. Variants of the P. falciparum chloroquine resistance transporter (pfcrt) gene have been shown to be responsible for conferring resistance to the commonly used drug chloroquine. In particular, an amino acid mutation, K76T, was shown to have a strong positive correlation with the chloroquine-resistant varieties of malaria parasites. Global studies have reported highly reduced genetic diversity surrounding K76T in the pfcrt gene, which indicates that the mutation has been a target of positive Darwinian natural selection. However, two recent studies of P. falciparum in India found high genetic diversity in the pfcrt gene, which, at first sight, do not support the role of natural selection in the evolution of chloroquine resistance in India. SN - 1471-4922 UR - https://www.unboundmedicine.com/medline/citation/17280870/Evolutionary_paradigm_of_chloroquine_resistant_malaria_in_India_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1471-4922(07)00028-1 DB - PRIME DP - Unbound Medicine ER -