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Serum lipids and glucose control: the SEARCH for Diabetes in Youth study.
Arch Pediatr Adolesc Med. 2007 Feb; 161(2):159-65.AP

Abstract

OBJECTIVE

To assess the relationship of serum lipid concentrations with glucose control in youth with diabetes mellitus.

DESIGN

Cross-sectional analyses of data from the SEARCH for Diabetes in Youth study.

SETTING

Multicenter study of youth with diabetes onset at younger than 20 years. PATIENTS/ PARTICIPANTS: Nineteen hundred seventy-three SEARCH participants aged 10 years or older with hemoglobin A(1c) and fasting total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglyceride measured at the SEARCH study examination.

MAIN EXPOSURE

Hemoglobin A(1c).

OUTCOME MEASURE

Lipid concentrations.

RESULTS

There were significant trends of higher levels of TC, LDL-C, triglyceride, and non-HDL-C (but not HDL-C) with higher hemoglobin A(1c) concentrations for both diabetes types. The slopes of TC increase were 7.8 mg/dL (0.20 mmol/L) per unit increase in hemoglobin A(1c) for type 1 and 8.1 mg/dL (0.21 mmol/L) for type 2. Levels of TC, LDL-C, triglyceride, and non-HDL-C were all significantly higher (all P values <.001) in type 2 than in type 1 diabetes (mean differences in milligrams per deciliter [millimoles per liter], +13.6 [+0.35] for TC; +8.3 [+0.22] for LDL-C; +66.3 [+0.75] for triglyceride; +25.5 [+0.66] for non-HDL-C). Levels of HDL-C were lower in youth with type 2 diabetes (mean difference, -11.9 mg/dL [-0.31 mmol/L]). Among those with type 1 diabetes in poor glycemic control, 35%, 27%, and 12% had high concentrations of TC (>or=200 mg/dL [5.17 mmol/L]), LDL-C (>or=130 mg/dL [3.36 mmol/L]), and triglyceride (>or=200 mg/dL [2.26 mmol/L]), respectively. In youth with type 2 diabetes in poor glycemic control, percentages with high levels of TC, LDL-C, and triglycerides were 65%, 43%, and 40%, respectively.

CONCLUSIONS

Glycemic control and lipid levels are independently associated in youth with both type 1 and type 2 diabetes.

Authors+Show Affiliations

Department of Research and Evaluation, Kaiser Permanente Southern California, 393 E Walnut St, Pasadena, CA 91188, USA. diana.b.petitti@kp.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

17283301

Citation

Petitti, Diana B., et al. "Serum Lipids and Glucose Control: the SEARCH for Diabetes in Youth Study." Archives of Pediatrics & Adolescent Medicine, vol. 161, no. 2, 2007, pp. 159-65.
Petitti DB, Imperatore G, Palla SL, et al. Serum lipids and glucose control: the SEARCH for Diabetes in Youth study. Arch Pediatr Adolesc Med. 2007;161(2):159-65.
Petitti, D. B., Imperatore, G., Palla, S. L., Daniels, S. R., Dolan, L. M., Kershnar, A. K., Marcovina, S., Pettitt, D. J., & Pihoker, C. (2007). Serum lipids and glucose control: the SEARCH for Diabetes in Youth study. Archives of Pediatrics & Adolescent Medicine, 161(2), 159-65.
Petitti DB, et al. Serum Lipids and Glucose Control: the SEARCH for Diabetes in Youth Study. Arch Pediatr Adolesc Med. 2007;161(2):159-65. PubMed PMID: 17283301.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum lipids and glucose control: the SEARCH for Diabetes in Youth study. AU - Petitti,Diana B, AU - Imperatore,Giuseppina, AU - Palla,Shana L, AU - Daniels,Stephen R, AU - Dolan,Lawrence M, AU - Kershnar,Ann K, AU - Marcovina,Santica, AU - Pettitt,David J, AU - Pihoker,Catherine, AU - ,, PY - 2007/2/7/pubmed PY - 2007/3/10/medline PY - 2007/2/7/entrez SP - 159 EP - 65 JF - Archives of pediatrics & adolescent medicine JO - Arch Pediatr Adolesc Med VL - 161 IS - 2 N2 - OBJECTIVE: To assess the relationship of serum lipid concentrations with glucose control in youth with diabetes mellitus. DESIGN: Cross-sectional analyses of data from the SEARCH for Diabetes in Youth study. SETTING: Multicenter study of youth with diabetes onset at younger than 20 years. PATIENTS/ PARTICIPANTS: Nineteen hundred seventy-three SEARCH participants aged 10 years or older with hemoglobin A(1c) and fasting total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglyceride measured at the SEARCH study examination. MAIN EXPOSURE: Hemoglobin A(1c). OUTCOME MEASURE: Lipid concentrations. RESULTS: There were significant trends of higher levels of TC, LDL-C, triglyceride, and non-HDL-C (but not HDL-C) with higher hemoglobin A(1c) concentrations for both diabetes types. The slopes of TC increase were 7.8 mg/dL (0.20 mmol/L) per unit increase in hemoglobin A(1c) for type 1 and 8.1 mg/dL (0.21 mmol/L) for type 2. Levels of TC, LDL-C, triglyceride, and non-HDL-C were all significantly higher (all P values <.001) in type 2 than in type 1 diabetes (mean differences in milligrams per deciliter [millimoles per liter], +13.6 [+0.35] for TC; +8.3 [+0.22] for LDL-C; +66.3 [+0.75] for triglyceride; +25.5 [+0.66] for non-HDL-C). Levels of HDL-C were lower in youth with type 2 diabetes (mean difference, -11.9 mg/dL [-0.31 mmol/L]). Among those with type 1 diabetes in poor glycemic control, 35%, 27%, and 12% had high concentrations of TC (>or=200 mg/dL [5.17 mmol/L]), LDL-C (>or=130 mg/dL [3.36 mmol/L]), and triglyceride (>or=200 mg/dL [2.26 mmol/L]), respectively. In youth with type 2 diabetes in poor glycemic control, percentages with high levels of TC, LDL-C, and triglycerides were 65%, 43%, and 40%, respectively. CONCLUSIONS: Glycemic control and lipid levels are independently associated in youth with both type 1 and type 2 diabetes. SN - 1072-4710 UR - https://www.unboundmedicine.com/medline/citation/17283301/Serum_lipids_and_glucose_control:_the_SEARCH_for_Diabetes_in_Youth_study_ L2 - https://jamanetwork.com/journals/jamapediatrics/fullarticle/10.1001/archpedi.161.2.159 DB - PRIME DP - Unbound Medicine ER -