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[Current value of seminal vesicle biopsy in patients with prostate cancer and influence of radical prostatectomy in patients with seminal vesicle invasion].
Arch Esp Urol. 2006 Dec; 59(10):977-88.AE

Abstract

OBJECTIVES

To evaluate if radical prostatectomy may positively influence cancer-specific survival (CSS), hormone-resistance-free time, metastasis-free time, and quality of life(QoL) of patients with prostate adenocarcinoma and seminal vesicle invasion, and also to update our thoughts about seminal vesicle biopsy.

METHODS

114 patients were included. Forty-six cases were diagnosed of seminal vesicle invasion after radical prostatectomy; 68 cases were diagnosed of seminal vesicle invasion after biopsy, not undergoing then surgery. Cancer specific survival, time to hormone resistance from the start of hormonal treatment, metastasis free time and QoL, measured as need for hospital care, were compared between groups. Median follow-up time was 52.6 mos.

RESULTS

There were not statistically significant differences between groups in CSS, time to hormone resistance, metastasis free time and QoL. Three and five-year cancer specific survival were 100% and 80.77% for the radical prostatectomy group and 74.4% and 56.2% for the biopsy group. Primary grade and Gleason Score were independent predictors for CSS in the Cox regression test; clinical stage was independent predictor for time to hormone resistance.

CONCLUSIONS

Radical prostatectomy as monotherapy does not show a statistically significant influence on followup time, CSS, time to hormone resistance, metastasis free time or QoL in patients with prostate cancer and seminal vesicle invasion associated with other bad prognostic factors (unfavourable Gleason and PSA). The value of seminal vesicle biopsy remains for the study of new multimodal treatments, such as chemotherapy + surgery, and it is to be defined in the planning of radio and cryosurgery.

Authors+Show Affiliations

Servicio de Urología, Hospital Universitario Miguel Servet, Pso. Isabel la Católica, 1 y 3, 50009 Zaragoza, España. callepuz@salud.aragon.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

spa

PubMed ID

17283711

Citation

Losa, Carlos Alberto Allepuz, et al. "[Current Value of Seminal Vesicle Biopsy in Patients With Prostate Cancer and Influence of Radical Prostatectomy in Patients With Seminal Vesicle Invasion]." Archivos Espanoles De Urologia, vol. 59, no. 10, 2006, pp. 977-88.
Losa CA, Fernando AB, Lázaro VA, et al. [Current value of seminal vesicle biopsy in patients with prostate cancer and influence of radical prostatectomy in patients with seminal vesicle invasion]. Arch Esp Urol. 2006;59(10):977-88.
Losa, C. A., Fernando, A. B., Lázaro, V. A., Berlanga, F. F., Frago, P. S., López, M. A., Sanz, M. J., Martínez, P. G., & Sanz, L. A. (2006). [Current value of seminal vesicle biopsy in patients with prostate cancer and influence of radical prostatectomy in patients with seminal vesicle invasion]. Archivos Espanoles De Urologia, 59(10), 977-88.
Losa CA, et al. [Current Value of Seminal Vesicle Biopsy in Patients With Prostate Cancer and Influence of Radical Prostatectomy in Patients With Seminal Vesicle Invasion]. Arch Esp Urol. 2006;59(10):977-88. PubMed PMID: 17283711.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Current value of seminal vesicle biopsy in patients with prostate cancer and influence of radical prostatectomy in patients with seminal vesicle invasion]. AU - Losa,Carlos Alberto Allepuz, AU - Fernando,Angel Borque, AU - Lázaro,Vicente Andrés, AU - Berlanga,Francesc Filipo, AU - Frago,Patricia Serrano, AU - López,Marta Allúe, AU - Sanz,María Jesús Gil, AU - Martínez,Pedro Gil, AU - Sanz,Luis Angel Rioja, PY - 2007/2/8/pubmed PY - 2007/4/27/medline PY - 2007/2/8/entrez SP - 977 EP - 88 JF - Archivos espanoles de urologia JO - Arch Esp Urol VL - 59 IS - 10 N2 - OBJECTIVES: To evaluate if radical prostatectomy may positively influence cancer-specific survival (CSS), hormone-resistance-free time, metastasis-free time, and quality of life(QoL) of patients with prostate adenocarcinoma and seminal vesicle invasion, and also to update our thoughts about seminal vesicle biopsy. METHODS: 114 patients were included. Forty-six cases were diagnosed of seminal vesicle invasion after radical prostatectomy; 68 cases were diagnosed of seminal vesicle invasion after biopsy, not undergoing then surgery. Cancer specific survival, time to hormone resistance from the start of hormonal treatment, metastasis free time and QoL, measured as need for hospital care, were compared between groups. Median follow-up time was 52.6 mos. RESULTS: There were not statistically significant differences between groups in CSS, time to hormone resistance, metastasis free time and QoL. Three and five-year cancer specific survival were 100% and 80.77% for the radical prostatectomy group and 74.4% and 56.2% for the biopsy group. Primary grade and Gleason Score were independent predictors for CSS in the Cox regression test; clinical stage was independent predictor for time to hormone resistance. CONCLUSIONS: Radical prostatectomy as monotherapy does not show a statistically significant influence on followup time, CSS, time to hormone resistance, metastasis free time or QoL in patients with prostate cancer and seminal vesicle invasion associated with other bad prognostic factors (unfavourable Gleason and PSA). The value of seminal vesicle biopsy remains for the study of new multimodal treatments, such as chemotherapy + surgery, and it is to be defined in the planning of radio and cryosurgery. SN - 0004-0614 UR - https://www.unboundmedicine.com/medline/citation/17283711/[Current_value_of_seminal_vesicle_biopsy_in_patients_with_prostate_cancer_and_influence_of_radical_prostatectomy_in_patients_with_seminal_vesicle_invasion]_ L2 - http://www.aeurologia.com/articulo_prod.php?id_art=4522925647231 DB - PRIME DP - Unbound Medicine ER -