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Eremophilane-type sesquiterpene derivatives from the roots of Ligularia lapathifolia.
J Nat Prod. 2007 Feb; 70(2):241-5.JN

Abstract

Six new highly oxygenated eremophilane-type sesquiterpene derivatives (1-6), including a norbisesquiterpene, were isolated from an extract of the roots of Ligularia lapathifolia, and their structures were elucidated by spectroscopic methods. The structure of 1 was confirmed by single-crystal X-ray crystallography. In addition, the cytotoxicity of compounds 1, 2, 3, 5, and 6 was evaluated against selected cancer cell lines, including human stomach carcinoma (MGC-803), human hepatoma (HEP-G2), and murine sarcoma (S-180) cell lines.

Authors+Show Affiliations

Fei DQ
State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, People's Republic of China.
Li SG
No affiliation info available
Liu CM
No affiliation info available
Wu G
No affiliation info available
Gao K
No affiliation info available

MeSH

AnimalsAntineoplastic Agents, PhytogenicAsteraceaeChinaCrystallography, X-RayDrug Screening Assays, AntitumorHumansMolecular ConformationMolecular StructurePlant RootsPlants, MedicinalSesquiterpenes

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17284071

Citation

Fei, Dong-Qing, et al. "Eremophilane-type Sesquiterpene Derivatives From the Roots of Ligularia Lapathifolia." Journal of Natural Products, vol. 70, no. 2, 2007, pp. 241-5.
Fei DQ, Li SG, Liu CM, et al. Eremophilane-type sesquiterpene derivatives from the roots of Ligularia lapathifolia. J Nat Prod. 2007;70(2):241-5.
Fei, D. Q., Li, S. G., Liu, C. M., Wu, G., & Gao, K. (2007). Eremophilane-type sesquiterpene derivatives from the roots of Ligularia lapathifolia. Journal of Natural Products, 70(2), 241-5.
Fei DQ, et al. Eremophilane-type Sesquiterpene Derivatives From the Roots of Ligularia Lapathifolia. J Nat Prod. 2007;70(2):241-5. PubMed PMID: 17284071.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Eremophilane-type sesquiterpene derivatives from the roots of Ligularia lapathifolia. AU - Fei,Dong-Qing, AU - Li,Shi-Gang, AU - Liu,Chun-Mei, AU - Wu,Gang, AU - Gao,Kun, Y1 - 2007/02/07/ PY - 2007/2/8/pubmed PY - 2007/4/5/medline PY - 2007/2/8/entrez SP - 241 EP - 5 JF - Journal of natural products JO - J Nat Prod VL - 70 IS - 2 N2 - Six new highly oxygenated eremophilane-type sesquiterpene derivatives (1-6), including a norbisesquiterpene, were isolated from an extract of the roots of Ligularia lapathifolia, and their structures were elucidated by spectroscopic methods. The structure of 1 was confirmed by single-crystal X-ray crystallography. In addition, the cytotoxicity of compounds 1, 2, 3, 5, and 6 was evaluated against selected cancer cell lines, including human stomach carcinoma (MGC-803), human hepatoma (HEP-G2), and murine sarcoma (S-180) cell lines. SN - 0163-3864 UR - https://www.unboundmedicine.com/medline/citation/17284071/Eremophilane_type_sesquiterpene_derivatives_from_the_roots_of_Ligularia_lapathifolia_ L2 - https://doi.org/10.1021/np060304k DB - PRIME DP - Unbound Medicine ER -