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Determinants of brain natriuretic peptide gene expression and secretion in acute cardiac allograft rejection.
Curr Opin Cardiol. 2007 Mar; 22(2):146-50.CO

Abstract

PURPOSE OF REVIEW

Circulating levels of the cardiac hormone brain natriuretic peptide in heart transplant patients may increase before and during an acute rejection episode. A similar increase in atrial natriuretic factor does not occur. This article reviews the possible significance of these findings.

RECENT FINDINGS

During acute cardiac allograft rejection episodes, brain natriuretic peptide plasma levels may increase well above baseline values. This increase is not the result of hemodynamic changes because brain natriuretic peptide levels during International Society for Heart and Lung Transplantation grade 3 rejection do not correlate with various hemodynamic parameters, and atrial natriuretic factor levels are not affected. Similar results were observed in experimentally induced autoimmune myocarditis. In-vitro data showed that some proinflammatory cytokines and chemokines are capable of selectively increasing brain natriuretic peptide gene expression and secretion in cardiocyte cultures.

SUMMARY

Atrial natriuretic factor and brain natriuretic peptide are usually co-regulated. Findings in heart allograft recipients, in experimentally induced myocarditis, and in vitro suggest that, unlike atrial natriuretic factor, brain natriuretic peptide is uniquely related to inflammation. These findings may translate into biomarkers or therapies for cardiac allograft rejection or myocarditis and may explain the existence of two hormones with nearly identical biologic properties.

Authors+Show Affiliations

Cardiovascular Endocrinology Laboratory, University of Ottawa Heart Institute, Ottawa, Ontario, Canada. adebold@ottawaheart.ca

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

17284995

Citation

de Bold, Adolfo J.. "Determinants of Brain Natriuretic Peptide Gene Expression and Secretion in Acute Cardiac Allograft Rejection." Current Opinion in Cardiology, vol. 22, no. 2, 2007, pp. 146-50.
de Bold AJ. Determinants of brain natriuretic peptide gene expression and secretion in acute cardiac allograft rejection. Curr Opin Cardiol. 2007;22(2):146-50.
de Bold, A. J. (2007). Determinants of brain natriuretic peptide gene expression and secretion in acute cardiac allograft rejection. Current Opinion in Cardiology, 22(2), 146-50.
de Bold AJ. Determinants of Brain Natriuretic Peptide Gene Expression and Secretion in Acute Cardiac Allograft Rejection. Curr Opin Cardiol. 2007;22(2):146-50. PubMed PMID: 17284995.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Determinants of brain natriuretic peptide gene expression and secretion in acute cardiac allograft rejection. A1 - de Bold,Adolfo J, PY - 2007/2/8/pubmed PY - 2007/8/11/medline PY - 2007/2/8/entrez SP - 146 EP - 50 JF - Current opinion in cardiology JO - Curr Opin Cardiol VL - 22 IS - 2 N2 - PURPOSE OF REVIEW: Circulating levels of the cardiac hormone brain natriuretic peptide in heart transplant patients may increase before and during an acute rejection episode. A similar increase in atrial natriuretic factor does not occur. This article reviews the possible significance of these findings. RECENT FINDINGS: During acute cardiac allograft rejection episodes, brain natriuretic peptide plasma levels may increase well above baseline values. This increase is not the result of hemodynamic changes because brain natriuretic peptide levels during International Society for Heart and Lung Transplantation grade 3 rejection do not correlate with various hemodynamic parameters, and atrial natriuretic factor levels are not affected. Similar results were observed in experimentally induced autoimmune myocarditis. In-vitro data showed that some proinflammatory cytokines and chemokines are capable of selectively increasing brain natriuretic peptide gene expression and secretion in cardiocyte cultures. SUMMARY: Atrial natriuretic factor and brain natriuretic peptide are usually co-regulated. Findings in heart allograft recipients, in experimentally induced myocarditis, and in vitro suggest that, unlike atrial natriuretic factor, brain natriuretic peptide is uniquely related to inflammation. These findings may translate into biomarkers or therapies for cardiac allograft rejection or myocarditis and may explain the existence of two hormones with nearly identical biologic properties. SN - 0268-4705 UR - https://www.unboundmedicine.com/medline/citation/17284995/Determinants_of_brain_natriuretic_peptide_gene_expression_and_secretion_in_acute_cardiac_allograft_rejection_ L2 - https://doi.org/10.1097/HCO.0b013e328028fd7e DB - PRIME DP - Unbound Medicine ER -