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Atypical antipsychotics and pituitary neoplasms in the WHO database.
Psychopharmacol Bull. 2007; 40(1):74-6.PB

Abstract

Amisulpride and risperidone are potent dopamine D2 receptor blocking atypical antipsychotics that can cause hyperprolactinemia. Preclinical evidence shows that chronic administration of antipsychotics can cause pituitary adenomas in female mice. To investigate the clinical relevance in this finding, reports of pituitary neoplasms in the WHO adverse drug reaction (ADR) database were reviewed. Amisulpride and risperidone [corrected] had among the highest Information Component (IC) scores for benign pituitary neoplasm; amisulpride (IC = 3.31, IC025 = 1.83, 5 reports) and risperidone (IC = 4.03, IC025 = 3.33, 19 reports), and not otherwise specified (NOS) pituitary neoplasm: amisulpride (IC = 2.69, IC025 = 0.70, 3 reports) and risperidone (IC = 4.49, IC025 = 3.86, 23 reports). We conclude that there is a need for prospective studies to confirm causality and suggest that clinicians, until then, would consider a pituitary adenoma in patients experiencing severe hyperprolactinemia or associated symptoms when receiving potent D2 antagonists [corrected]

Authors+Show Affiliations

Department of Psychiatry and the Department of Medicine at Duke University Medical Center, DUMC 3018, Durham, NC 27514, USA. dorai001@mc.duke.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17285098

Citation

Doraiswamy, P Murali, et al. "Atypical Antipsychotics and Pituitary Neoplasms in the WHO Database." Psychopharmacology Bulletin, vol. 40, no. 1, 2007, pp. 74-6.
Doraiswamy PM, Schott G, Star K, et al. Atypical antipsychotics and pituitary neoplasms in the WHO database. Psychopharmacol Bull. 2007;40(1):74-6.
Doraiswamy, P. M., Schott, G., Star, K., Edwards, R., & Mueller-Oerlinghausen, B. (2007). Atypical antipsychotics and pituitary neoplasms in the WHO database. Psychopharmacology Bulletin, 40(1), 74-6.
Doraiswamy PM, et al. Atypical Antipsychotics and Pituitary Neoplasms in the WHO Database. Psychopharmacol Bull. 2007;40(1):74-6. PubMed PMID: 17285098.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Atypical antipsychotics and pituitary neoplasms in the WHO database. AU - Doraiswamy,P Murali, AU - Schott,Gisela, AU - Star,Kristina, AU - Edwards,Ralph, AU - Mueller-Oerlinghausen,Bruno, PY - 2007/2/8/pubmed PY - 2007/5/3/medline PY - 2007/2/8/entrez SP - 74 EP - 6 JF - Psychopharmacology bulletin JO - Psychopharmacol Bull VL - 40 IS - 1 N2 - Amisulpride and risperidone are potent dopamine D2 receptor blocking atypical antipsychotics that can cause hyperprolactinemia. Preclinical evidence shows that chronic administration of antipsychotics can cause pituitary adenomas in female mice. To investigate the clinical relevance in this finding, reports of pituitary neoplasms in the WHO adverse drug reaction (ADR) database were reviewed. Amisulpride and risperidone [corrected] had among the highest Information Component (IC) scores for benign pituitary neoplasm; amisulpride (IC = 3.31, IC025 = 1.83, 5 reports) and risperidone (IC = 4.03, IC025 = 3.33, 19 reports), and not otherwise specified (NOS) pituitary neoplasm: amisulpride (IC = 2.69, IC025 = 0.70, 3 reports) and risperidone (IC = 4.49, IC025 = 3.86, 23 reports). We conclude that there is a need for prospective studies to confirm causality and suggest that clinicians, until then, would consider a pituitary adenoma in patients experiencing severe hyperprolactinemia or associated symptoms when receiving potent D2 antagonists [corrected] SN - 0048-5764 UR - https://www.unboundmedicine.com/medline/citation/17285098/Atypical_antipsychotics_and_pituitary_neoplasms_in_the_WHO_database_ L2 - https://medlineplus.gov/pituitarytumors.html DB - PRIME DP - Unbound Medicine ER -