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Jejunal secretion of secretory immunoglobulins and gliadin antibodies in celiac disease.
Dig Dis Sci. 1992 Jan; 37(1):53-9.DD

Abstract

The aim of this study was to determine the secretion of secretory immunoglobulins and gliadin antibodies in the small bowel in celiac disease. Twenty-four patients were investigated by perfusion of a defined jejunal segment. Four of the patients studied had a serum IgA deficiency and had no measurable amounts of secretory IgA in the perfusion fluid. The other patients demonstrated a significant increase in the jejunal concentration of secretory IgA (median 28.5 mg/liter) compared with healthy controls (median 16 mg/liter, N = 16) and of IgM, celiac (median 12.3 mg/liter) compared to healthy controls (median 6.8 mg/liter, N = 16). Jejunal IgA gliadin antibodies were detected in all patients except those with an IgA deficiency. All patients had jejunal IgM gliadin antibodies, but none of the patients had measurable jejunal IgG gliadin antibodies. A positive correlation was detected between serum and jejunal IgA gliadin antibody levels in the celiac patients, (P less than 0.01). Calculation of the ratio between gliadin antibodies and total levels of IgA and IgM in serum and jejunal perfusate demonstrated that the jejunal synthesis of gliadin antibodies of IgA and IgM type is both more pronounced and persistent than the systemic humoral immune response to gliadin.

Authors+Show Affiliations

Department of Internal Medicine, University Hospital, Uppsala, Sweden.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1728531

Citation

Lavö, B, et al. "Jejunal Secretion of Secretory Immunoglobulins and Gliadin Antibodies in Celiac Disease." Digestive Diseases and Sciences, vol. 37, no. 1, 1992, pp. 53-9.
Lavö B, Knutson F, Knutson L, et al. Jejunal secretion of secretory immunoglobulins and gliadin antibodies in celiac disease. Dig Dis Sci. 1992;37(1):53-9.
Lavö, B., Knutson, F., Knutson, L., Sjöberg, O., & Hällgren, R. (1992). Jejunal secretion of secretory immunoglobulins and gliadin antibodies in celiac disease. Digestive Diseases and Sciences, 37(1), 53-9.
Lavö B, et al. Jejunal Secretion of Secretory Immunoglobulins and Gliadin Antibodies in Celiac Disease. Dig Dis Sci. 1992;37(1):53-9. PubMed PMID: 1728531.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Jejunal secretion of secretory immunoglobulins and gliadin antibodies in celiac disease. AU - Lavö,B, AU - Knutson,F, AU - Knutson,L, AU - Sjöberg,O, AU - Hällgren,R, PY - 1992/1/1/pubmed PY - 1992/1/1/medline PY - 1992/1/1/entrez SP - 53 EP - 9 JF - Digestive diseases and sciences JO - Dig Dis Sci VL - 37 IS - 1 N2 - The aim of this study was to determine the secretion of secretory immunoglobulins and gliadin antibodies in the small bowel in celiac disease. Twenty-four patients were investigated by perfusion of a defined jejunal segment. Four of the patients studied had a serum IgA deficiency and had no measurable amounts of secretory IgA in the perfusion fluid. The other patients demonstrated a significant increase in the jejunal concentration of secretory IgA (median 28.5 mg/liter) compared with healthy controls (median 16 mg/liter, N = 16) and of IgM, celiac (median 12.3 mg/liter) compared to healthy controls (median 6.8 mg/liter, N = 16). Jejunal IgA gliadin antibodies were detected in all patients except those with an IgA deficiency. All patients had jejunal IgM gliadin antibodies, but none of the patients had measurable jejunal IgG gliadin antibodies. A positive correlation was detected between serum and jejunal IgA gliadin antibody levels in the celiac patients, (P less than 0.01). Calculation of the ratio between gliadin antibodies and total levels of IgA and IgM in serum and jejunal perfusate demonstrated that the jejunal synthesis of gliadin antibodies of IgA and IgM type is both more pronounced and persistent than the systemic humoral immune response to gliadin. SN - 0163-2116 UR - https://www.unboundmedicine.com/medline/citation/1728531/Jejunal_secretion_of_secretory_immunoglobulins_and_gliadin_antibodies_in_celiac_disease_ L2 - https://www.diseaseinfosearch.org/result/1186 DB - PRIME DP - Unbound Medicine ER -