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A comparison of the physical and intellectual development of black children with and without sickle-cell trait.
Pediatrics. 1975 Dec; 56(6):1021-5.Ped

Abstract

Sickle-cell trait, a condition present in 7% to 9% of the United States Black population, is usually considered to be a clinically benign condition. However, there is increasing evidence to indicate the contrary, that is, the clinical pathophysiology is variable, ranging from a benign condition in most cases to a relatively few cases of severe pathological involvement. Physical and intellectual growth measures were taken on 19 children with sickle-cell trait (12 boys and 7 girls) from a large study of Black same-sex twin pairs from Philadelphia, Pennsylvania, and compared to measures taken of a sample of normal Black children from 155 monozygotic and dizygotic same-sex twin pairs. Sickle-cell trait carriers were found to weigh less, have smaller upper arm circumference lesser skinfold thickness, and showed less mature skeletal age, differing significantly from normal children. Sickle-cell carriers tended to score lower on four of five intellectual measures, scoring one fifth to one third of a standard deviation lower than normal children.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

172854

Citation

McCormack, M K., et al. "A Comparison of the Physical and Intellectual Development of Black Children With and Without Sickle-cell Trait." Pediatrics, vol. 56, no. 6, 1975, pp. 1021-5.
McCormack MK, Scarr-Salapatek S, Polesky H, et al. A comparison of the physical and intellectual development of black children with and without sickle-cell trait. Pediatrics. 1975;56(6):1021-5.
McCormack, M. K., Scarr-Salapatek, S., Polesky, H., Thompson, W., Katz, S. H., & Barker, W. B. (1975). A comparison of the physical and intellectual development of black children with and without sickle-cell trait. Pediatrics, 56(6), 1021-5.
McCormack MK, et al. A Comparison of the Physical and Intellectual Development of Black Children With and Without Sickle-cell Trait. Pediatrics. 1975;56(6):1021-5. PubMed PMID: 172854.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A comparison of the physical and intellectual development of black children with and without sickle-cell trait. AU - McCormack,M K, AU - Scarr-Salapatek,S, AU - Polesky,H, AU - Thompson,W, AU - Katz,S H, AU - Barker,W B, PY - 1975/12/1/pubmed PY - 1975/12/1/medline PY - 1975/12/1/entrez SP - 1021 EP - 5 JF - Pediatrics JO - Pediatrics VL - 56 IS - 6 N2 - Sickle-cell trait, a condition present in 7% to 9% of the United States Black population, is usually considered to be a clinically benign condition. However, there is increasing evidence to indicate the contrary, that is, the clinical pathophysiology is variable, ranging from a benign condition in most cases to a relatively few cases of severe pathological involvement. Physical and intellectual growth measures were taken on 19 children with sickle-cell trait (12 boys and 7 girls) from a large study of Black same-sex twin pairs from Philadelphia, Pennsylvania, and compared to measures taken of a sample of normal Black children from 155 monozygotic and dizygotic same-sex twin pairs. Sickle-cell trait carriers were found to weigh less, have smaller upper arm circumference lesser skinfold thickness, and showed less mature skeletal age, differing significantly from normal children. Sickle-cell carriers tended to score lower on four of five intellectual measures, scoring one fifth to one third of a standard deviation lower than normal children. SN - 0031-4005 UR - https://www.unboundmedicine.com/medline/citation/172854/A_comparison_of_the_physical_and_intellectual_development_of_black_children_with_and_without_sickle_cell_trait_ L2 - http://pediatrics.aappublications.org/cgi/pmidlookup?view=long&pmid=172854 DB - PRIME DP - Unbound Medicine ER -