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[A color test for rapid screening of gamma-hydroxybutyric acid (GHB) and gamma-butyrolactone (GBL) in drink and urine].
Fa Yi Xue Za Zhi. 2006 Dec; 22(6):424-7.FY

Abstract

OBJECTIVE

A rapid color test for screening gamma-hydroxybutyric acid (GHB) and its precursor gamma-butyrolactone(GBL) was investigated in drink and urine samples.

METHODS

In an acidic solution, GHB was converted to GBL, which reacted with hydroxylamine hydrochloride in presence of sodium hydroxide, forming hydroxamate. A purple complex was formed when hydroxamate reacted with ferric chloride in acidic condition.

RESULTS

Detection limit concentrations of GHB in drinks were between 0.5-2 mg/mL, less than the popular abuse concentrations of GHB. This method was usable for urine, with detection limit concentration 0.5 mg/mL. Interferences of common organic solvents and narcotics and depressants were surveyed.

CONCLUSION

This method is simple, safe, and rapid; it facilitates rapid screening of GHB and GBL in clinic and forensic laboratories.

Authors+Show Affiliations

Fujian Public Security College, Fuzhou 350007, China. shaoyuzhang@126.comNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

17285863

Citation

Zhang, Shao-yu, and Zeng-ping Huang. "[A Color Test for Rapid Screening of Gamma-hydroxybutyric Acid (GHB) and Gamma-butyrolactone (GBL) in Drink and Urine]." Fa Yi Xue Za Zhi, vol. 22, no. 6, 2006, pp. 424-7.
Zhang SY, Huang ZP. [A color test for rapid screening of gamma-hydroxybutyric acid (GHB) and gamma-butyrolactone (GBL) in drink and urine]. Fa Yi Xue Za Zhi. 2006;22(6):424-7.
Zhang, S. Y., & Huang, Z. P. (2006). [A color test for rapid screening of gamma-hydroxybutyric acid (GHB) and gamma-butyrolactone (GBL) in drink and urine]. Fa Yi Xue Za Zhi, 22(6), 424-7.
Zhang SY, Huang ZP. [A Color Test for Rapid Screening of Gamma-hydroxybutyric Acid (GHB) and Gamma-butyrolactone (GBL) in Drink and Urine]. Fa Yi Xue Za Zhi. 2006;22(6):424-7. PubMed PMID: 17285863.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [A color test for rapid screening of gamma-hydroxybutyric acid (GHB) and gamma-butyrolactone (GBL) in drink and urine]. AU - Zhang,Shao-yu, AU - Huang,Zeng-ping, PY - 2007/2/9/pubmed PY - 2010/6/4/medline PY - 2007/2/9/entrez SP - 424 EP - 7 JF - Fa yi xue za zhi JO - Fa Yi Xue Za Zhi VL - 22 IS - 6 N2 - OBJECTIVE: A rapid color test for screening gamma-hydroxybutyric acid (GHB) and its precursor gamma-butyrolactone(GBL) was investigated in drink and urine samples. METHODS: In an acidic solution, GHB was converted to GBL, which reacted with hydroxylamine hydrochloride in presence of sodium hydroxide, forming hydroxamate. A purple complex was formed when hydroxamate reacted with ferric chloride in acidic condition. RESULTS: Detection limit concentrations of GHB in drinks were between 0.5-2 mg/mL, less than the popular abuse concentrations of GHB. This method was usable for urine, with detection limit concentration 0.5 mg/mL. Interferences of common organic solvents and narcotics and depressants were surveyed. CONCLUSION: This method is simple, safe, and rapid; it facilitates rapid screening of GHB and GBL in clinic and forensic laboratories. SN - 1004-5619 UR - https://www.unboundmedicine.com/medline/citation/17285863/[A_color_test_for_rapid_screening_of_gamma_hydroxybutyric_acid__GHB__and_gamma_butyrolactone__GBL__in_drink_and_urine]_ L2 - https://www.lens.org/lens/search/patent/list?q=citation_id:17285863 DB - PRIME DP - Unbound Medicine ER -