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[Effect of Fuzheng Jiangan formula on liver fibrosis induced by albumin in rats].
Zhongguo Zhong Yao Za Zhi. 2006 Nov; 31(22):1890-3.ZZ

Abstract

OBJECTIVE

To observe the effect of Fuzheng Jiangan formula(FZJGF) on liver fibrosis using immune induced liver fibrosis rat model.

METHOD

The rat models with immunity liver fibrosis were induced by the human serum albumin. Rats were treated with normal saline, FZJGF (9. 85,39. 4 g x kg(-1) , two dosage groups) and Colchicine (0. 000 1 g . kg(-1)). The activities of ALT, AST, contents of ALB and TP, and A/G, The contents of Laminin (LN), Hyaluronic acid (HA) and collagen type IV (IV-C) in rat serum were measured by radioimmunoassay method. The level of hydroxyproline (Hyp) in liver was detected by chemistry method. The pathological changes of liver tissue were observed by HE and Von-Gieson staining.

RESULT

FZJGF could significant decrease the serum activities of ALT and AST, and increase the levels of TP,Alb and ratio A/G. The levels of LN, HA and IV-C were decreased significantly after the treatment using FZJGF. The pathological improvements were observed. FZJGF could markedly alleviate the deposition of collageneous fiber, and reduce the liver pseudoluboli and the fibrosis scores in the liver tissue compared with model group.

CONCLUSION

FZJGF can inhibit formation and development of rat hepatic fibrosis induced by the human serum albumin.

Authors+Show Affiliations

Department of Infectious Diseases, Dong Fang Hospital, Beijing University of Chinese Medicine, Beijing 100078, China. hxiangan@163.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

17285992

Citation

Huang, Xiang-an, et al. "[Effect of Fuzheng Jiangan Formula On Liver Fibrosis Induced By Albumin in Rats]." Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica, vol. 31, no. 22, 2006, pp. 1890-3.
Huang XA, Sun LH, Song CS, et al. [Effect of Fuzheng Jiangan formula on liver fibrosis induced by albumin in rats]. Zhongguo Zhong Yao Za Zhi. 2006;31(22):1890-3.
Huang, X. A., Sun, L. H., Song, C. S., Cui, N., Chen, Y. L., Xu, H. Y., & Ren, Y. (2006). [Effect of Fuzheng Jiangan formula on liver fibrosis induced by albumin in rats]. Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica, 31(22), 1890-3.
Huang XA, et al. [Effect of Fuzheng Jiangan Formula On Liver Fibrosis Induced By Albumin in Rats]. Zhongguo Zhong Yao Za Zhi. 2006;31(22):1890-3. PubMed PMID: 17285992.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effect of Fuzheng Jiangan formula on liver fibrosis induced by albumin in rats]. AU - Huang,Xiang-an, AU - Sun,Li-hong, AU - Song,Chong-shun, AU - Cui,Ning, AU - Chen,Yan-li, AU - Xu,Hong-yan, AU - Ren,Ying, PY - 2007/2/9/pubmed PY - 2008/4/25/medline PY - 2007/2/9/entrez SP - 1890 EP - 3 JF - Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica JO - Zhongguo Zhong Yao Za Zhi VL - 31 IS - 22 N2 - OBJECTIVE: To observe the effect of Fuzheng Jiangan formula(FZJGF) on liver fibrosis using immune induced liver fibrosis rat model. METHOD: The rat models with immunity liver fibrosis were induced by the human serum albumin. Rats were treated with normal saline, FZJGF (9. 85,39. 4 g x kg(-1) , two dosage groups) and Colchicine (0. 000 1 g . kg(-1)). The activities of ALT, AST, contents of ALB and TP, and A/G, The contents of Laminin (LN), Hyaluronic acid (HA) and collagen type IV (IV-C) in rat serum were measured by radioimmunoassay method. The level of hydroxyproline (Hyp) in liver was detected by chemistry method. The pathological changes of liver tissue were observed by HE and Von-Gieson staining. RESULT: FZJGF could significant decrease the serum activities of ALT and AST, and increase the levels of TP,Alb and ratio A/G. The levels of LN, HA and IV-C were decreased significantly after the treatment using FZJGF. The pathological improvements were observed. FZJGF could markedly alleviate the deposition of collageneous fiber, and reduce the liver pseudoluboli and the fibrosis scores in the liver tissue compared with model group. CONCLUSION: FZJGF can inhibit formation and development of rat hepatic fibrosis induced by the human serum albumin. SN - 1001-5302 UR - https://www.unboundmedicine.com/medline/citation/17285992/[Effect_of_Fuzheng_Jiangan_formula_on_liver_fibrosis_induced_by_albumin_in_rats]_ DB - PRIME DP - Unbound Medicine ER -