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Drug-polymer microparticles produced by supercritical assisted atomization.
Biotechnol Bioeng. 2007 Aug 15; 97(6):1626-37.BB

Abstract

The supercritical assisted atomization (SAA) was proposed as a new technique to produce composite microparticles for drug controlled release. Ampicillin trihydrate and chitosan were selected as model drug and carrier, respectively, and 1% v/v acetic acid aqueous solution was used as solvent. The effect of the polymer/drug ratio on particle morphology and drug release rate was evaluated. SEM analysis indicated that non-coalescing spherical microparticles formed by chitosan/ampicillin were produced by SAA. All coprecipitates produced have a sharp particle distribution, with diameters ranging between about 0.1 and 6 microm. SAA composite microparticles were characterized by X-ray, DSC, EDX and UV-vis analysis. A solid solution of the chitosan and ampicillin was produced and a stabilizing effect of the polymer on the drug has resulted that protects ampicillin from thermal degradation. A prolonged release from SAA coprecipitates with respect to raw drug and physical mixtures of chitosan and ampicillin was obtained; moreover, the polymer/drug ratio has revealed to be a controlling parameter for drug release. Drug release mechanisms characteristic of swelling-controlled systems were observed, with ampicillin release depending on both relaxation and diffusive mechanisms. An empirical binomial equation was used to describe experimental data, showing a fair good agreement with ampicillin release data if both the relaxational and the diffusional parameters are function of the polymer/drug ratio.

Authors+Show Affiliations

Dipartimento di Ingegneria Chimica e Alimentare, Università degli Studi di Salerno, Via Ponte Don Melillo, 84084 Fisciano (SA), Italy. ereverchon@unisa.itNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17286274

Citation

Reverchon, Ernesto, and Alessandra Antonacci. "Drug-polymer Microparticles Produced By Supercritical Assisted Atomization." Biotechnology and Bioengineering, vol. 97, no. 6, 2007, pp. 1626-37.
Reverchon E, Antonacci A. Drug-polymer microparticles produced by supercritical assisted atomization. Biotechnol Bioeng. 2007;97(6):1626-37.
Reverchon, E., & Antonacci, A. (2007). Drug-polymer microparticles produced by supercritical assisted atomization. Biotechnology and Bioengineering, 97(6), 1626-37.
Reverchon E, Antonacci A. Drug-polymer Microparticles Produced By Supercritical Assisted Atomization. Biotechnol Bioeng. 2007 Aug 15;97(6):1626-37. PubMed PMID: 17286274.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Drug-polymer microparticles produced by supercritical assisted atomization. AU - Reverchon,Ernesto, AU - Antonacci,Alessandra, PY - 2007/2/9/pubmed PY - 2007/9/19/medline PY - 2007/2/9/entrez SP - 1626 EP - 37 JF - Biotechnology and bioengineering JO - Biotechnol Bioeng VL - 97 IS - 6 N2 - The supercritical assisted atomization (SAA) was proposed as a new technique to produce composite microparticles for drug controlled release. Ampicillin trihydrate and chitosan were selected as model drug and carrier, respectively, and 1% v/v acetic acid aqueous solution was used as solvent. The effect of the polymer/drug ratio on particle morphology and drug release rate was evaluated. SEM analysis indicated that non-coalescing spherical microparticles formed by chitosan/ampicillin were produced by SAA. All coprecipitates produced have a sharp particle distribution, with diameters ranging between about 0.1 and 6 microm. SAA composite microparticles were characterized by X-ray, DSC, EDX and UV-vis analysis. A solid solution of the chitosan and ampicillin was produced and a stabilizing effect of the polymer on the drug has resulted that protects ampicillin from thermal degradation. A prolonged release from SAA coprecipitates with respect to raw drug and physical mixtures of chitosan and ampicillin was obtained; moreover, the polymer/drug ratio has revealed to be a controlling parameter for drug release. Drug release mechanisms characteristic of swelling-controlled systems were observed, with ampicillin release depending on both relaxation and diffusive mechanisms. An empirical binomial equation was used to describe experimental data, showing a fair good agreement with ampicillin release data if both the relaxational and the diffusional parameters are function of the polymer/drug ratio. SN - 0006-3592 UR - https://www.unboundmedicine.com/medline/citation/17286274/Drug_polymer_microparticles_produced_by_supercritical_assisted_atomization_ L2 - https://doi.org/10.1002/bit.21370 DB - PRIME DP - Unbound Medicine ER -