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Clinical significance of autoantibodies recognizing Sjögren's syndrome A (SSA), SSB, calpastatin and alpha-fodrin in primary Sjögren's syndrome.
Clin Exp Immunol. 2007 May; 148(2):281-7.CE

Abstract

The aim of our study was (i) to compare the clinical and biological characteristics of 148 (137 women, 11 men) primary Sjögren's syndrome (pSS) patients at diagnosis as a function of their sex and (ii) to assess the prognostic value of anti-calpastatin and anti-alpha-fodrin autoantibodies. In addition, the presence of anti-nuclear antibodies (ANA), anti-52- and 60-kDa Sjögren's syndrome A (SSA), anti-Sjögren's syndrome B (SSB), anti-cyclic citrullinated peptide (CCP) antibodies and rheumatoid factors (RF) of IgA, IgG and IgM isotypes was sought in sera collected at pSS onset. Raynaud's syndrome, significantly more frequent in women, was the only systemic manifestation of pSS whose frequency differed significantly as a function of the patient's sex (P = 0.02). ANA (P = 0.001) and anti-60-kDa SSA autoantibodies (P = 0.03) were significantly more common in women, while men never synthesized detectable levels of anti-SSB, anti-calpastatin or IgG anti-alpha-fodrin autoantibodies. In addition, anti-CCP autoantibodies were found in low percentages of pSS patients (4% F/18% M). The absence of autoantibodies does not exclude the diagnosis of pSS in men that will be based mainly on the anatomopathological findings of a minor salivary gland biopsy. Positivity of anti-60-kDa SSA, anti-SSB, anti-calpastatin, IgA and IgG anti-alpha-fodrin antibodies is not associated with pSS clinical and biological severity.

Authors+Show Affiliations

Department of Rheumatology, Rouen University Hospital & Inserm U519 (IFRMP23), Institute for Biomedical Research, University of Rouen, Rouen, France. goebvince@yahoo.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17286756

Citation

Goëb, V, et al. "Clinical Significance of Autoantibodies Recognizing Sjögren's Syndrome a (SSA), SSB, Calpastatin and Alpha-fodrin in Primary Sjögren's Syndrome." Clinical and Experimental Immunology, vol. 148, no. 2, 2007, pp. 281-7.
Goëb V, Salle V, Duhaut P, et al. Clinical significance of autoantibodies recognizing Sjögren's syndrome A (SSA), SSB, calpastatin and alpha-fodrin in primary Sjögren's syndrome. Clin Exp Immunol. 2007;148(2):281-7.
Goëb, V., Salle, V., Duhaut, P., Jouen, F., Smail, A., Ducroix, J. P., Tron, F., Le Loët, X., & Vittecoq, O. (2007). Clinical significance of autoantibodies recognizing Sjögren's syndrome A (SSA), SSB, calpastatin and alpha-fodrin in primary Sjögren's syndrome. Clinical and Experimental Immunology, 148(2), 281-7.
Goëb V, et al. Clinical Significance of Autoantibodies Recognizing Sjögren's Syndrome a (SSA), SSB, Calpastatin and Alpha-fodrin in Primary Sjögren's Syndrome. Clin Exp Immunol. 2007;148(2):281-7. PubMed PMID: 17286756.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical significance of autoantibodies recognizing Sjögren's syndrome A (SSA), SSB, calpastatin and alpha-fodrin in primary Sjögren's syndrome. AU - Goëb,V, AU - Salle,V, AU - Duhaut,P, AU - Jouen,F, AU - Smail,A, AU - Ducroix,J-P, AU - Tron,F, AU - Le Loët,X, AU - Vittecoq,O, Y1 - 2007/02/07/ PY - 2007/2/9/pubmed PY - 2007/6/19/medline PY - 2007/2/9/entrez SP - 281 EP - 7 JF - Clinical and experimental immunology JO - Clin Exp Immunol VL - 148 IS - 2 N2 - The aim of our study was (i) to compare the clinical and biological characteristics of 148 (137 women, 11 men) primary Sjögren's syndrome (pSS) patients at diagnosis as a function of their sex and (ii) to assess the prognostic value of anti-calpastatin and anti-alpha-fodrin autoantibodies. In addition, the presence of anti-nuclear antibodies (ANA), anti-52- and 60-kDa Sjögren's syndrome A (SSA), anti-Sjögren's syndrome B (SSB), anti-cyclic citrullinated peptide (CCP) antibodies and rheumatoid factors (RF) of IgA, IgG and IgM isotypes was sought in sera collected at pSS onset. Raynaud's syndrome, significantly more frequent in women, was the only systemic manifestation of pSS whose frequency differed significantly as a function of the patient's sex (P = 0.02). ANA (P = 0.001) and anti-60-kDa SSA autoantibodies (P = 0.03) were significantly more common in women, while men never synthesized detectable levels of anti-SSB, anti-calpastatin or IgG anti-alpha-fodrin autoantibodies. In addition, anti-CCP autoantibodies were found in low percentages of pSS patients (4% F/18% M). The absence of autoantibodies does not exclude the diagnosis of pSS in men that will be based mainly on the anatomopathological findings of a minor salivary gland biopsy. Positivity of anti-60-kDa SSA, anti-SSB, anti-calpastatin, IgA and IgG anti-alpha-fodrin antibodies is not associated with pSS clinical and biological severity. SN - 0009-9104 UR - https://www.unboundmedicine.com/medline/citation/17286756/Clinical_significance_of_autoantibodies_recognizing_Sjögren's_syndrome_A__SSA__SSB_calpastatin_and_alpha_fodrin_in_primary_Sjögren's_syndrome_ L2 - https://doi.org/10.1111/j.1365-2249.2007.03337.x DB - PRIME DP - Unbound Medicine ER -