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Prevalence of nonalcoholic fatty liver disease in women with polycystic ovary syndrome.
Clin Gastroenterol Hepatol. 2007 Apr; 5(4):496-501.CG

Abstract

BACKGROUND & AIMS

Insulin resistance has been implicated in the pathogenesis of both nonalcoholic fatty liver disease (NAFLD) and polycystic ovary syndrome (PCOS). We hypothesized that NAFLD would be common in both obese and nonobese women with PCOS. The aim of this study was to estimate the prevalence of and identify associated factors for hepatic steatosis in women with PCOS.

METHODS

This is a retrospective study of 88 consecutive premenopausal women with PCOS. Clinical history, height, weight, and laboratory values were obtained. Fasting measurements of serum glucose and insulin were used to calculate homeostasis model assessment of insulin resistance (HOMA-IR). Abdominal ultrasonography was used to determine the presence and severity of hepatic steatosis.

RESULTS

Of the 88 women (median age, 31.4 years), 48 (55%) had steatosis; 15 (39%) of them were lean women. The presence of steatosis was associated with a greater body mass index (BMI) (P = .005) and HOMA-IR (P = .033), a lower fasting high-density lipoprotein (P = .003), and a greater prevalence of impaired fasting glucose, impaired glucose tolerance, and diabetes mellitus (P = .013). Only 7 (15%) subjects with hepatic steatosis had abnormal liver chemistries.

CONCLUSIONS

Fatty liver was identified in 55% of subjects with PCOS, nearly 40% of whom were lean women. High BMI and insulin resistance appeared to be important associated factors. Early recognition of NAFLD in this group of young patients is warranted, and further investigation including liver biopsy might be indicated.

Authors+Show Affiliations

Division of Gastroenterology and Hepatology, Weill Medical College of Cornell University, New York, NY 10021, USA. mag2046@med.cornell.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17287148

Citation

Gambarin-Gelwan, Maya, et al. "Prevalence of Nonalcoholic Fatty Liver Disease in Women With Polycystic Ovary Syndrome." Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association, vol. 5, no. 4, 2007, pp. 496-501.
Gambarin-Gelwan M, Kinkhabwala SV, Schiano TD, et al. Prevalence of nonalcoholic fatty liver disease in women with polycystic ovary syndrome. Clin Gastroenterol Hepatol. 2007;5(4):496-501.
Gambarin-Gelwan, M., Kinkhabwala, S. V., Schiano, T. D., Bodian, C., Yeh, H. C., & Futterweit, W. (2007). Prevalence of nonalcoholic fatty liver disease in women with polycystic ovary syndrome. Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association, 5(4), 496-501.
Gambarin-Gelwan M, et al. Prevalence of Nonalcoholic Fatty Liver Disease in Women With Polycystic Ovary Syndrome. Clin Gastroenterol Hepatol. 2007;5(4):496-501. PubMed PMID: 17287148.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence of nonalcoholic fatty liver disease in women with polycystic ovary syndrome. AU - Gambarin-Gelwan,Maya, AU - Kinkhabwala,Sanjiv V, AU - Schiano,Thomas D, AU - Bodian,Carol, AU - Yeh,Hsu-Chong, AU - Futterweit,Walter, Y1 - 2007/02/06/ PY - 2007/2/9/pubmed PY - 2007/5/11/medline PY - 2007/2/9/entrez SP - 496 EP - 501 JF - Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association JO - Clin. Gastroenterol. Hepatol. VL - 5 IS - 4 N2 - BACKGROUND & AIMS: Insulin resistance has been implicated in the pathogenesis of both nonalcoholic fatty liver disease (NAFLD) and polycystic ovary syndrome (PCOS). We hypothesized that NAFLD would be common in both obese and nonobese women with PCOS. The aim of this study was to estimate the prevalence of and identify associated factors for hepatic steatosis in women with PCOS. METHODS: This is a retrospective study of 88 consecutive premenopausal women with PCOS. Clinical history, height, weight, and laboratory values were obtained. Fasting measurements of serum glucose and insulin were used to calculate homeostasis model assessment of insulin resistance (HOMA-IR). Abdominal ultrasonography was used to determine the presence and severity of hepatic steatosis. RESULTS: Of the 88 women (median age, 31.4 years), 48 (55%) had steatosis; 15 (39%) of them were lean women. The presence of steatosis was associated with a greater body mass index (BMI) (P = .005) and HOMA-IR (P = .033), a lower fasting high-density lipoprotein (P = .003), and a greater prevalence of impaired fasting glucose, impaired glucose tolerance, and diabetes mellitus (P = .013). Only 7 (15%) subjects with hepatic steatosis had abnormal liver chemistries. CONCLUSIONS: Fatty liver was identified in 55% of subjects with PCOS, nearly 40% of whom were lean women. High BMI and insulin resistance appeared to be important associated factors. Early recognition of NAFLD in this group of young patients is warranted, and further investigation including liver biopsy might be indicated. SN - 1542-7714 UR - https://www.unboundmedicine.com/medline/citation/17287148/Prevalence_of_nonalcoholic_fatty_liver_disease_in_women_with_polycystic_ovary_syndrome_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1542-3565(06)01048-2 DB - PRIME DP - Unbound Medicine ER -