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Effects of some H1-antagonists on the sleep-wake cycle in sleep-disturbed rats.
J Pharmacol Sci. 2007 Feb; 103(2):201-6.JP

Abstract

The present study was undertaken to investigate the effects of some H(1)-antagonists on the sleep-wake cycle in sleep-disturbed rats in comparison with those of nitrazepam. Electrodes were chronically implanted into the frontal cortex and the dorsal neck muscle of rats for the electroencephalogram (EEG) and electromyogram (EMG), respectively. EEG and EMG were recorded with an electroencephalograph. SleepSign ver. 2.0 was used for EEG and EMG analysis. The total times of waking, non-rapid eye movement (non-REM), and rapid eye movement (REM) sleep were measured from 10:00 to 16:00. Nitrazepam showed a significant decrease in sleep latency, total waking time, and delta activity and an increase in the total non-REM sleep time. A significant decrease in the sleep latency was observed with diphenhydramine, chlorpheniramine, and cyproheptadine. Cyproheptadine also caused a significant decrease in the total waking time and increases in total non-REM sleep time, REM sleep time, slow wave sleep, and delta activity, although no remarkable effects were observed with diphenhydramine and chlorpheniramine. In conclusion, cyproheptadine can be useful as a hypnotic, having not only sleep inducing-effects, but also sleep quantity- and quality-increasing effects.

Authors+Show Affiliations

Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Tsushima-naka 1-1-1, Okayama 700-8530, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17287588

Citation

Tokunaga, Shin, et al. "Effects of some H1-antagonists On the Sleep-wake Cycle in Sleep-disturbed Rats." Journal of Pharmacological Sciences, vol. 103, no. 2, 2007, pp. 201-6.
Tokunaga S, Takeda Y, Shinomiya K, et al. Effects of some H1-antagonists on the sleep-wake cycle in sleep-disturbed rats. J Pharmacol Sci. 2007;103(2):201-6.
Tokunaga, S., Takeda, Y., Shinomiya, K., Hirase, M., & Kamei, C. (2007). Effects of some H1-antagonists on the sleep-wake cycle in sleep-disturbed rats. Journal of Pharmacological Sciences, 103(2), 201-6.
Tokunaga S, et al. Effects of some H1-antagonists On the Sleep-wake Cycle in Sleep-disturbed Rats. J Pharmacol Sci. 2007;103(2):201-6. PubMed PMID: 17287588.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of some H1-antagonists on the sleep-wake cycle in sleep-disturbed rats. AU - Tokunaga,Shin, AU - Takeda,Yasuhiro, AU - Shinomiya,Kazuaki, AU - Hirase,Masahiro, AU - Kamei,Chiaki, Y1 - 2007/02/08/ PY - 2007/2/9/pubmed PY - 2007/5/10/medline PY - 2007/2/9/entrez SP - 201 EP - 6 JF - Journal of pharmacological sciences JO - J Pharmacol Sci VL - 103 IS - 2 N2 - The present study was undertaken to investigate the effects of some H(1)-antagonists on the sleep-wake cycle in sleep-disturbed rats in comparison with those of nitrazepam. Electrodes were chronically implanted into the frontal cortex and the dorsal neck muscle of rats for the electroencephalogram (EEG) and electromyogram (EMG), respectively. EEG and EMG were recorded with an electroencephalograph. SleepSign ver. 2.0 was used for EEG and EMG analysis. The total times of waking, non-rapid eye movement (non-REM), and rapid eye movement (REM) sleep were measured from 10:00 to 16:00. Nitrazepam showed a significant decrease in sleep latency, total waking time, and delta activity and an increase in the total non-REM sleep time. A significant decrease in the sleep latency was observed with diphenhydramine, chlorpheniramine, and cyproheptadine. Cyproheptadine also caused a significant decrease in the total waking time and increases in total non-REM sleep time, REM sleep time, slow wave sleep, and delta activity, although no remarkable effects were observed with diphenhydramine and chlorpheniramine. In conclusion, cyproheptadine can be useful as a hypnotic, having not only sleep inducing-effects, but also sleep quantity- and quality-increasing effects. SN - 1347-8613 UR - https://www.unboundmedicine.com/medline/citation/17287588/Effects_of_some_H1_antagonists_on_the_sleep_wake_cycle_in_sleep_disturbed_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/JST.JSTAGE/jphs/FP0061173 DB - PRIME DP - Unbound Medicine ER -