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Protein, iron, and meat consumption and risk for rheumatoid arthritis: a prospective cohort study.

Abstract

A recent prospective study showed that higher consumption of red meat and total protein was associated with increased risk for inflammatory polyarthritis. We therefore prospectively examined the relationship between diet (in particular, protein, iron, and corresponding food sources) and incident rheumatoid arthritis (RA) among 82,063 women in the Nurses' Health Study. From 1980 to 2002, 546 incident cases of RA were confirmed by a connective tissue disease screening questionnaire and medical record review for American College of Rheumatology criteria for RA. Diet was assessed at baseline in 1980 and five additional times during follow up. We conducted Cox proportional hazards analyses to calculate the rate ratio of RA associated with intakes of protein (total, animal, and vegetable) and iron (total, dietary, from supplements, and heme iron) and their primary food sources, adjusting for age, smoking, body mass index, and reproductive factors. The multivariate models revealed no association between RA and any measure of protein or iron intake. In comparisons of highest with lowest quintiles of intake, the rate ratio for total protein was 1.17 (95% confidence interval 0.89-1.54; P for trend = 0.11) and for total iron it was 1.04 (95% confidence interval 0.77-1.41; P for trend = 0.82). Red meat, poultry, and fish were also not associated with RA risk. We were unable to confirm that there is an association between protein or meat and risk for RA in this large female cohort. Iron was also not associated with RA in this cohort.

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  • Authors+Show Affiliations

    ,

    Section of Clinical Sciences, Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham & Women's Hospital, Francis Street, Boston, Massachusetts 02115, USA. ebenitogarcia@bioepi.com

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    MeSH

    Adult
    Arthritis, Rheumatoid
    Cohort Studies
    Dietary Proteins
    Female
    Humans
    Iron, Dietary
    Meat
    Middle Aged
    Prospective Studies
    Risk Factors
    Surveys and Questionnaires

    Pub Type(s)

    Comparative Study
    Journal Article
    Research Support, N.I.H., Extramural

    Language

    eng

    PubMed ID

    17288585

    Citation

    Benito-Garcia, Elizabeth, et al. "Protein, Iron, and Meat Consumption and Risk for Rheumatoid Arthritis: a Prospective Cohort Study." Arthritis Research & Therapy, vol. 9, no. 1, 2007, pp. R16.
    Benito-Garcia E, Feskanich D, Hu FB, et al. Protein, iron, and meat consumption and risk for rheumatoid arthritis: a prospective cohort study. Arthritis Res Ther. 2007;9(1):R16.
    Benito-Garcia, E., Feskanich, D., Hu, F. B., Mandl, L. A., & Karlson, E. W. (2007). Protein, iron, and meat consumption and risk for rheumatoid arthritis: a prospective cohort study. Arthritis Research & Therapy, 9(1), pp. R16.
    Benito-Garcia E, et al. Protein, Iron, and Meat Consumption and Risk for Rheumatoid Arthritis: a Prospective Cohort Study. Arthritis Res Ther. 2007;9(1):R16. PubMed PMID: 17288585.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Protein, iron, and meat consumption and risk for rheumatoid arthritis: a prospective cohort study. AU - Benito-Garcia,Elizabeth, AU - Feskanich,Diane, AU - Hu,Frank B, AU - Mandl,Lisa A, AU - Karlson,Elizabeth W, PY - 2006/11/03/received PY - 2007/01/15/revised PY - 2007/02/08/accepted PY - 2007/2/10/pubmed PY - 2007/5/1/medline PY - 2007/2/10/entrez SP - R16 EP - R16 JF - Arthritis research & therapy JO - Arthritis Res. Ther. VL - 9 IS - 1 N2 - A recent prospective study showed that higher consumption of red meat and total protein was associated with increased risk for inflammatory polyarthritis. We therefore prospectively examined the relationship between diet (in particular, protein, iron, and corresponding food sources) and incident rheumatoid arthritis (RA) among 82,063 women in the Nurses' Health Study. From 1980 to 2002, 546 incident cases of RA were confirmed by a connective tissue disease screening questionnaire and medical record review for American College of Rheumatology criteria for RA. Diet was assessed at baseline in 1980 and five additional times during follow up. We conducted Cox proportional hazards analyses to calculate the rate ratio of RA associated with intakes of protein (total, animal, and vegetable) and iron (total, dietary, from supplements, and heme iron) and their primary food sources, adjusting for age, smoking, body mass index, and reproductive factors. The multivariate models revealed no association between RA and any measure of protein or iron intake. In comparisons of highest with lowest quintiles of intake, the rate ratio for total protein was 1.17 (95% confidence interval 0.89-1.54; P for trend = 0.11) and for total iron it was 1.04 (95% confidence interval 0.77-1.41; P for trend = 0.82). Red meat, poultry, and fish were also not associated with RA risk. We were unable to confirm that there is an association between protein or meat and risk for RA in this large female cohort. Iron was also not associated with RA in this cohort. SN - 1478-6362 UR - https://www.unboundmedicine.com/medline/citation/17288585/full_citation L2 - https://arthritis-research.biomedcentral.com/articles/10.1186/ar2123 DB - PRIME DP - Unbound Medicine ER -