Tags

Type your tag names separated by a space and hit enter

Effect of Cassia fistula Linn. leaf extract on diethylnitrosamine induced hepatic injury in rats.
Chem Biol Interact 2007; 167(1):12-8CB

Abstract

The hepatoprotective and antioxidant effect of Cassia fistula Linn. leaf extract on liver injury induced by diethylnitrosamine (DEN) was investigated. Wistar rats weighing 200+/-10g were administered a single dose of DEN (200mg/kg b.w., i.p.) and left for 30 days. For hepatoprotective studies, ethanolic leaf extract (ELE) of C. fistula Linn. (500mg/kg b.w., p.o.) was administered daily for 30 days. AST, ALT, ALP, LDH, gamma-GT and bilirubin were estimated in serum and liver tissue. Lipid peroxidation (LPO), SOD and CAT were also estimated in liver tissue as markers of oxidative stress. DEN induced hepatotoxicity in all the treated animals were evident by elevated serum ALT, AST, ALP and bilirubin levels and a simultaneous fall in their levels in the liver tissue after 30 days. Induction of oxidative stress in the liver was evidenced by increased LPO and fall in the activities of SOD and CAT. ELE administration for 30 days prevented the DEN induced hepatic injury and oxidative stress. In conclusion, it was observed that ELE of C. fistula Linn. protects the liver against DEN induced hepatic injury in rats.

Authors+Show Affiliations

Department of Pharmacology and Environmental Toxicology, Dr. A.L.M. P.G. Institute of Basic Medical Science, University of Madras, Taramani, Chennai 600113, India. kannampallipradeep@rediffmail.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17289008

Citation

Pradeep, Kannampalli, et al. "Effect of Cassia Fistula Linn. Leaf Extract On Diethylnitrosamine Induced Hepatic Injury in Rats." Chemico-biological Interactions, vol. 167, no. 1, 2007, pp. 12-8.
Pradeep K, Mohan CV, Gobianand K, et al. Effect of Cassia fistula Linn. leaf extract on diethylnitrosamine induced hepatic injury in rats. Chem Biol Interact. 2007;167(1):12-8.
Pradeep, K., Mohan, C. V., Gobianand, K., & Karthikeyan, S. (2007). Effect of Cassia fistula Linn. leaf extract on diethylnitrosamine induced hepatic injury in rats. Chemico-biological Interactions, 167(1), pp. 12-8.
Pradeep K, et al. Effect of Cassia Fistula Linn. Leaf Extract On Diethylnitrosamine Induced Hepatic Injury in Rats. Chem Biol Interact. 2007 Apr 5;167(1):12-8. PubMed PMID: 17289008.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of Cassia fistula Linn. leaf extract on diethylnitrosamine induced hepatic injury in rats. AU - Pradeep,Kannampalli, AU - Mohan,Chandrasekaran Victor Raj, AU - Gobianand,Kuppannan, AU - Karthikeyan,Sivanesan, Y1 - 2006/12/30/ PY - 2006/09/22/received PY - 2006/12/17/revised PY - 2006/12/20/accepted PY - 2007/2/10/pubmed PY - 2007/5/30/medline PY - 2007/2/10/entrez SP - 12 EP - 8 JF - Chemico-biological interactions JO - Chem. Biol. Interact. VL - 167 IS - 1 N2 - The hepatoprotective and antioxidant effect of Cassia fistula Linn. leaf extract on liver injury induced by diethylnitrosamine (DEN) was investigated. Wistar rats weighing 200+/-10g were administered a single dose of DEN (200mg/kg b.w., i.p.) and left for 30 days. For hepatoprotective studies, ethanolic leaf extract (ELE) of C. fistula Linn. (500mg/kg b.w., p.o.) was administered daily for 30 days. AST, ALT, ALP, LDH, gamma-GT and bilirubin were estimated in serum and liver tissue. Lipid peroxidation (LPO), SOD and CAT were also estimated in liver tissue as markers of oxidative stress. DEN induced hepatotoxicity in all the treated animals were evident by elevated serum ALT, AST, ALP and bilirubin levels and a simultaneous fall in their levels in the liver tissue after 30 days. Induction of oxidative stress in the liver was evidenced by increased LPO and fall in the activities of SOD and CAT. ELE administration for 30 days prevented the DEN induced hepatic injury and oxidative stress. In conclusion, it was observed that ELE of C. fistula Linn. protects the liver against DEN induced hepatic injury in rats. SN - 0009-2797 UR - https://www.unboundmedicine.com/medline/citation/17289008/Effect_of_Cassia_fistula_Linn__leaf_extract_on_diethylnitrosamine_induced_hepatic_injury_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0009-2797(06)00364-4 DB - PRIME DP - Unbound Medicine ER -