Citation
Hayakawa, Kazuhide, et al. "Delta9-tetrahydrocannabinol (Delta9-THC) Prevents Cerebral Infarction Via Hypothalamic-independent Hypothermia." Life Sciences, vol. 80, no. 16, 2007, pp. 1466-71.
Hayakawa K, Mishima K, Nozako M, et al. Delta9-tetrahydrocannabinol (Delta9-THC) prevents cerebral infarction via hypothalamic-independent hypothermia. Life Sci. 2007;80(16):1466-71.
Hayakawa, K., Mishima, K., Nozako, M., Hazekawa, M., Ogata, A., Fujioka, M., Harada, K., Mishima, S., Orito, K., Egashira, N., Iwasaki, K., & Fujiwara, M. (2007). Delta9-tetrahydrocannabinol (Delta9-THC) prevents cerebral infarction via hypothalamic-independent hypothermia. Life Sciences, 80(16), 1466-71.
Hayakawa K, et al. Delta9-tetrahydrocannabinol (Delta9-THC) Prevents Cerebral Infarction Via Hypothalamic-independent Hypothermia. Life Sci. 2007 Mar 27;80(16):1466-71. PubMed PMID: 17289082.
TY - JOUR
T1 - Delta9-tetrahydrocannabinol (Delta9-THC) prevents cerebral infarction via hypothalamic-independent hypothermia.
AU - Hayakawa,Kazuhide,
AU - Mishima,Kenichi,
AU - Nozako,Masanori,
AU - Hazekawa,Mai,
AU - Ogata,Ayumi,
AU - Fujioka,Masayuki,
AU - Harada,Kazuhiko,
AU - Mishima,Shohei,
AU - Orito,Kensuke,
AU - Egashira,Nobuaki,
AU - Iwasaki,Katunori,
AU - Fujiwara,Michihiro,
Y1 - 2007/01/19/
PY - 2006/10/06/received
PY - 2006/12/28/revised
PY - 2007/01/06/accepted
PY - 2007/2/10/pubmed
PY - 2007/6/29/medline
PY - 2007/2/10/entrez
SP - 1466
EP - 71
JF - Life sciences
JO - Life Sci
VL - 80
IS - 16
N2 - Delta(9)-tetrahydrocannabinol (Delta(9)-THC), a primary psychoactive constituent of cannabis, has been reported to act as a neuroprotectant via the cannabinoid CB(1) receptor. In this study, Delta(9)-THC significantly decreased the infarct volume in a 4 h mouse middle cerebral artery occlusion mouse model. The neuroprotective effect of Delta(9)-THC was completely abolished by SR141716, cannabinoid CB(1) receptor antagonist, and by warming the animals to 31 degrees C. Delta(9)-THC significantly decreased the rectal temperature, and the hypothermic effect was also inhibited by SR141716 and by warming to 31 degrees C. At 24 h after cerebral ischemia, Delta(9)-THC significantly increased the expression level of CB(1) receptor in both the striatum and cortex, but not in the hypothalamus. Warming to 31 degrees C during 4 h cerebral ischemia did not increase the expression of CB(1) receptor at the striatum and cortex in MCA-occluded mice. These results show that the neuroprotective effect of Delta(9)-THC is mediated by a temperature-dependent mechanism via the CB(1) receptor. In addition, warming to 31 degrees C might attenuate both the neuroprotective and hypothermic effects of Delta(9)-THC through inhibiting the increase in CB(1) receptor in both the striatum and cortex but not in the hypothalamus, which may suggest a new thermoregulation mechanism of Delta(9)-THC.
SN - 0024-3205
UR - https://www.unboundmedicine.com/medline/citation/17289082/Delta9_tetrahydrocannabinol__Delta9_THC__prevents_cerebral_infarction_via_hypothalamic_independent_hypothermia_
L2 - https://linkinghub.elsevier.com/retrieve/pii/S0024-3205(07)00063-X
DB - PRIME
DP - Unbound Medicine
ER -