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Delta9-tetrahydrocannabinol (Delta9-THC) prevents cerebral infarction via hypothalamic-independent hypothermia.
Life Sci. 2007 Mar 27; 80(16):1466-71.LS

Abstract

Delta(9)-tetrahydrocannabinol (Delta(9)-THC), a primary psychoactive constituent of cannabis, has been reported to act as a neuroprotectant via the cannabinoid CB(1) receptor. In this study, Delta(9)-THC significantly decreased the infarct volume in a 4 h mouse middle cerebral artery occlusion mouse model. The neuroprotective effect of Delta(9)-THC was completely abolished by SR141716, cannabinoid CB(1) receptor antagonist, and by warming the animals to 31 degrees C. Delta(9)-THC significantly decreased the rectal temperature, and the hypothermic effect was also inhibited by SR141716 and by warming to 31 degrees C. At 24 h after cerebral ischemia, Delta(9)-THC significantly increased the expression level of CB(1) receptor in both the striatum and cortex, but not in the hypothalamus. Warming to 31 degrees C during 4 h cerebral ischemia did not increase the expression of CB(1) receptor at the striatum and cortex in MCA-occluded mice. These results show that the neuroprotective effect of Delta(9)-THC is mediated by a temperature-dependent mechanism via the CB(1) receptor. In addition, warming to 31 degrees C might attenuate both the neuroprotective and hypothermic effects of Delta(9)-THC through inhibiting the increase in CB(1) receptor in both the striatum and cortex but not in the hypothalamus, which may suggest a new thermoregulation mechanism of Delta(9)-THC.

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Authors+Show Affiliations

Hayakawa K
Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Nanakuma 8-19-1, Fukuoka City, Fukuoka, Japan.
Mishima K
No affiliation info available
Nozako M
No affiliation info available
Hazekawa M
No affiliation info available
Ogata A
No affiliation info available
Fujioka M
No affiliation info available
Harada K
No affiliation info available
Mishima S
No affiliation info available
Orito K
No affiliation info available
Egashira N
No affiliation info available
Iwasaki K
No affiliation info available
Fujiwara M
No affiliation info available

MeSH

Analysis of VarianceAnimalsBlotting, WesternBody TemperatureBody Temperature RegulationCerebral CortexCerebral InfarctionDronabinolElectrophoresis, Polyacrylamide GelGene Expression RegulationHypothermia, InducedMaleMicePiperidinesPyrazolesRimonabantTetrazolium Salts

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17289082

Citation

Hayakawa, Kazuhide, et al. "Delta9-tetrahydrocannabinol (Delta9-THC) Prevents Cerebral Infarction Via Hypothalamic-independent Hypothermia." Life Sciences, vol. 80, no. 16, 2007, pp. 1466-71.
Hayakawa K, Mishima K, Nozako M, et al. Delta9-tetrahydrocannabinol (Delta9-THC) prevents cerebral infarction via hypothalamic-independent hypothermia. Life Sci. 2007;80(16):1466-71.
Hayakawa, K., Mishima, K., Nozako, M., Hazekawa, M., Ogata, A., Fujioka, M., Harada, K., Mishima, S., Orito, K., Egashira, N., Iwasaki, K., & Fujiwara, M. (2007). Delta9-tetrahydrocannabinol (Delta9-THC) prevents cerebral infarction via hypothalamic-independent hypothermia. Life Sciences, 80(16), 1466-71.
Hayakawa K, et al. Delta9-tetrahydrocannabinol (Delta9-THC) Prevents Cerebral Infarction Via Hypothalamic-independent Hypothermia. Life Sci. 2007 Mar 27;80(16):1466-71. PubMed PMID: 17289082.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Delta9-tetrahydrocannabinol (Delta9-THC) prevents cerebral infarction via hypothalamic-independent hypothermia. AU - Hayakawa,Kazuhide, AU - Mishima,Kenichi, AU - Nozako,Masanori, AU - Hazekawa,Mai, AU - Ogata,Ayumi, AU - Fujioka,Masayuki, AU - Harada,Kazuhiko, AU - Mishima,Shohei, AU - Orito,Kensuke, AU - Egashira,Nobuaki, AU - Iwasaki,Katunori, AU - Fujiwara,Michihiro, Y1 - 2007/01/19/ PY - 2006/10/06/received PY - 2006/12/28/revised PY - 2007/01/06/accepted PY - 2007/2/10/pubmed PY - 2007/6/29/medline PY - 2007/2/10/entrez SP - 1466 EP - 71 JF - Life sciences JO - Life Sci VL - 80 IS - 16 N2 - Delta(9)-tetrahydrocannabinol (Delta(9)-THC), a primary psychoactive constituent of cannabis, has been reported to act as a neuroprotectant via the cannabinoid CB(1) receptor. In this study, Delta(9)-THC significantly decreased the infarct volume in a 4 h mouse middle cerebral artery occlusion mouse model. The neuroprotective effect of Delta(9)-THC was completely abolished by SR141716, cannabinoid CB(1) receptor antagonist, and by warming the animals to 31 degrees C. Delta(9)-THC significantly decreased the rectal temperature, and the hypothermic effect was also inhibited by SR141716 and by warming to 31 degrees C. At 24 h after cerebral ischemia, Delta(9)-THC significantly increased the expression level of CB(1) receptor in both the striatum and cortex, but not in the hypothalamus. Warming to 31 degrees C during 4 h cerebral ischemia did not increase the expression of CB(1) receptor at the striatum and cortex in MCA-occluded mice. These results show that the neuroprotective effect of Delta(9)-THC is mediated by a temperature-dependent mechanism via the CB(1) receptor. In addition, warming to 31 degrees C might attenuate both the neuroprotective and hypothermic effects of Delta(9)-THC through inhibiting the increase in CB(1) receptor in both the striatum and cortex but not in the hypothalamus, which may suggest a new thermoregulation mechanism of Delta(9)-THC. SN - 0024-3205 UR - https://www.unboundmedicine.com/medline/citation/17289082/Delta9_tetrahydrocannabinol__Delta9_THC__prevents_cerebral_infarction_via_hypothalamic_independent_hypothermia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0024-3205(07)00063-X DB - PRIME DP - Unbound Medicine ER -